(95 nodes) Regulation of muscle system process network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KBTBD13	Kelch repeat and BTB domain containing 13. (503 aa)
	LOC103465822	Troponin I4b, tandem duplicate 2. (178 aa)
	LOC103465821	Uncharacterized protein. (183 aa)
	LOC103465820	Troponin I4b, tandem duplicate 2. (182 aa)
	LOC103465819	Troponin I4a. (177 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (421 aa)
	TNNC1	Troponin C type 1a (slow). (163 aa)
	LOC103463442	Thromboxane A2 receptor. (379 aa)
	LOC103463443	Thromboxane A2 receptor. (378 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	LOC103472964	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (449 aa)
	LOC103476675	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (410 aa)
	anxa6	Annexin. (665 aa)
	SRF	Serum response factor. (243 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (430 aa)
	LOC103464471	Tumor necrosis factor receptor superfamily, member 1B. (441 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (623 aa)
	LOC103466251	Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	LOC103461289	Phosphodiesterase. (447 aa)
	LOC103476588	Uncharacterized protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. (336 aa)
	LOC103469848	Protein kinase domain-containing protein. (526 aa)
	LOC103466900	Troponin C type 2 (fast). (173 aa)
	LOC103466898	Si:rp71-17i16.4. (216 aa)
	kcnq1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (631 aa)
	myog	Myogenin. (246 aa)
	LOC103472252	ANK_REP_REGION domain-containing protein. (1132 aa)
	LOC103470404	Cardiomyopathy associated 5. (1606 aa)
	akap6	A kinase (PRKA) anchor protein 6. (2553 aa)
	Cav1	Uncharacterized protein. (84 aa)
	LOC103468062	Troponin C type 1b (slow). (161 aa)
	LOC103465649	Troponin T type 3a (skeletal, fast). (369 aa)
	kbtbd13	Kelch repeat and BTB (POZ) domain containing 13. (489 aa)
	ankrd28	Ankyrin repeat domain 28b. (1052 aa)
	pkd2	Polycystic kidney disease 2. (893 aa)
	parp2	Poly [ADP-ribose] polymerase. (647 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
	mstn	Myostatin b. (376 aa)
	LOC103459424	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (422 aa)
	gja5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (376 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	LOC103464341	Adrenoceptor alpha 2C. (476 aa)
	LOC103465321	Junction plakoglobin a. (721 aa)
	LOC103465824	Uncharacterized protein. (237 aa)
	edn1	Endothelin 1. (207 aa)
	srf	Serum response factor b. (570 aa)
	LOC103462827	Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	tacr3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	ENSPREP00000014507	UBA_6 domain-containing protein. (200 aa)
	ENSPREP00000014606	Uncharacterized protein. (228 aa)
	dock4	Dedicator of cytokinesis 4b; Belongs to the DOCK family. (1978 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (333 aa)
	ENSPREP00000017976	Spexin hormone. (157 aa)
	Pln	Uncharacterized protein. (180 aa)
	ENSPREP00000018067	Troponin T type 2b (cardiac). (221 aa)
	LOC103464710	Troponin I type 1b (skeletal, slow). (170 aa)
	LOC103476774	G_PROTEIN_RECEP_F1_2 domain-containing protein. (399 aa)
	ENSPREP00000018153	Troponin T type 1 (skeletal, slow). (196 aa)
	LOC103474249	Grancalcin. (230 aa)
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	gsk3a	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (438 aa)
	gtf2ird1	GTF2I repeat domain containing 1. (1013 aa)
	ADRA2C	Adrenoceptor alpha 2C. (425 aa)
	RNF207	Ring finger protein 207a. (564 aa)
	LOC103471983	Endothelin 2. (172 aa)
	LOC103473191	Tachykinin receptor 1b; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	LOC103469542	Tachykinin receptor 1a; Belongs to the G-protein coupled receptor 1 family. (429 aa)
	Ctdp1	FCP1 homology domain-containing protein. (271 aa)
	LOC103458342	Ankyrin repeat domain 66. (181 aa)
	LOC103473346	Insulin-like growth factor binding protein 5a. (248 aa)
	rusc1	RUN and SH3 domain containing 1. (655 aa)
	tomm70	Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae). (578 aa)
	ucn	Urotensin 1. (147 aa)
	ENSPREP00000027277	Uncharacterized protein. (207 aa)
	sri	Uncharacterized protein. (187 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	LOC103473499	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	mymk	Myomaker, myoblast fusion factor. (217 aa)
	ENSPREP00000028578	Ion_trans domain-containing protein; Belongs to the potassium channel family. (424 aa)
	nkx2-5	NK2 homeobox 5. (316 aa)
	zdhhc21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	LOC103467415	Troponin T type 2a (cardiac). (281 aa)
	tnni1	Troponin I type 1a (skeletal, slow). (205 aa)
	nmu	NMU domain-containing protein. (153 aa)
	ankrd44	Ankyrin repeat domain 44. (1054 aa)
	casq1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (494 aa)
	LOC103461867	Insulin-like growth factor binding protein 5a. (270 aa)
	LOC103478871	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (545 aa)
	tnnt1	Uncharacterized protein. (251 aa)
	mlip	Uncharacterized protein. (848 aa)
	Pde9a	Phosphodiesterase 9A like; Belongs to the cyclic nucleotide phosphodiesterase family. (276 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (280 aa)
	lmcd1	LIM and cysteine-rich domains 1. (366 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cav1	LOC103465321	ENSPREP00000003891	ENSPREP00000000600	Uncharacterized protein.	Junction plakoglobin a.	0.458
Cav1	anxa6	ENSPREP00000003891	ENSPREP00000008911	Uncharacterized protein.	Annexin.	0.445
Cav1	cav3	ENSPREP00000003891	ENSPREP00000013872	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.544
ENSPREP00000014606	ENSPREP00000018153	ENSPREP00000014606	ENSPREP00000018153	Uncharacterized protein.	Troponin T type 1 (skeletal, slow).	0.408
ENSPREP00000014606	ENSPREP00000027277	ENSPREP00000014606	ENSPREP00000027277	Uncharacterized protein.	Uncharacterized protein.	0.415
ENSPREP00000014606	LOC103464710	ENSPREP00000014606	ENSPREP00000018100	Uncharacterized protein.	Troponin I type 1b (skeletal, slow).	0.879
ENSPREP00000014606	LOC103465649	ENSPREP00000014606	ENSPREP00000002843	Uncharacterized protein.	Troponin T type 3a (skeletal, fast).	0.413
ENSPREP00000014606	LOC103465819	ENSPREP00000014606	ENSPREP00000012191	Uncharacterized protein.	Troponin I4a.	0.780
ENSPREP00000014606	LOC103465820	ENSPREP00000014606	ENSPREP00000012264	Uncharacterized protein.	Troponin I4b, tandem duplicate 2.	0.818
ENSPREP00000014606	LOC103465821	ENSPREP00000014606	ENSPREP00000012478	Uncharacterized protein.	Uncharacterized protein.	0.830
ENSPREP00000014606	LOC103465822	ENSPREP00000014606	ENSPREP00000012522	Uncharacterized protein.	Troponin I4b, tandem duplicate 2.	0.826
ENSPREP00000014606	LOC103466898	ENSPREP00000014606	ENSPREP00000005662	Uncharacterized protein.	Si:rp71-17i16.4.	0.753
ENSPREP00000014606	LOC103466900	ENSPREP00000014606	ENSPREP00000005708	Uncharacterized protein.	Troponin C type 2 (fast).	0.753
ENSPREP00000014606	LOC103467415	ENSPREP00000014606	ENSPREP00000029363	Uncharacterized protein.	Troponin T type 2a (cardiac).	0.904
ENSPREP00000014606	LOC103468062	ENSPREP00000014606	ENSPREP00000003392	Uncharacterized protein.	Troponin C type 1b (slow).	0.967
ENSPREP00000014606	TNNC1	ENSPREP00000014606	ENSPREP00000011929	Uncharacterized protein.	Troponin C type 1a (slow).	0.967
ENSPREP00000014606	tnni1	ENSPREP00000014606	ENSPREP00000029394	Uncharacterized protein.	Troponin I type 1a (skeletal, slow).	0.875
ENSPREP00000018067	ENSPREP00000018153	ENSPREP00000018067	ENSPREP00000018153	Troponin T type 2b (cardiac).	Troponin T type 1 (skeletal, slow).	0.457
ENSPREP00000018067	ENSPREP00000027277	ENSPREP00000018067	ENSPREP00000027277	Troponin T type 2b (cardiac).	Uncharacterized protein.	0.446
ENSPREP00000018067	LOC103464710	ENSPREP00000018067	ENSPREP00000018100	Troponin T type 2b (cardiac).	Troponin I type 1b (skeletal, slow).	0.878