(71 nodes) Positive regulation of canonical Wnt signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Bb. (419 aa)
	ENSPREP00000000846	Ring finger protein 220a. (258 aa)
	RNF220	Uncharacterized protein. (239 aa)
	LOC103467771	DUF4203 domain-containing protein. (336 aa)
	LOC103459281	Transducin beta like 1 X-linked. (513 aa)
	LOC103467734	Uncharacterized protein. (229 aa)
	lrrk1	Uncharacterized protein. (2016 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (242 aa)
	Cav1	Uncharacterized protein. (84 aa)
	ppm1b	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba. (380 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	LOC103481540	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb. (469 aa)
	eda	Ectodysplasin A; Belongs to the tumor necrosis factor family. (369 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (787 aa)
	LOC103473565	Poly [ADP-ribose] polymerase. (1285 aa)
	rspo1	R-spondin 1. (273 aa)
	csnk1g1	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (466 aa)
	LOC103479069	Transducin (beta)-like 1 X-linked receptor 1b. (514 aa)
	LOC103481573	Family with sequence similarity 53 member B. (393 aa)
	LOC103469200	G protein-coupled receptor, class C, group 5, member Ba. (397 aa)
	csnk1d	Casein kinase 1, delta b; Belongs to the protein kinase superfamily. (389 aa)
	adgra2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
	atp6ap2	ATPase H+ transporting accessory protein 2. (381 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1317 aa)
	LYPD6	LY6/PLAUR domain containing 6. (179 aa)
	LOC103465114	WNK lysine deficient protein kinase 2. (2243 aa)
	wls	Wnt ligand secretion mediator. (448 aa)
	LOC103468226	Casein kinase 1 gamma 2. (515 aa)
	ILK	Integrin linked kinase. (452 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1042 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	PRDM15	PR/SET domain 15. (1117 aa)
	ENSPREP00000014417	WNK lysine deficient protein kinase 2. (1538 aa)
	LOC103479254	Protein kinase domain-containing protein. (505 aa)
	LOC103461633	Transmembrane protein 198a. (391 aa)
	FAM53B	Family with sequence similarity 53 member B. (438 aa)
	ENSPREP00000017955	C1q domain-containing protein. (310 aa)
	LOC103457724	Ring finger protein 146. (362 aa)
	RNF146	Ring finger protein 146. (388 aa)
	bambi	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (278 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	reck	Reversion-inducing-cysteine-rich protein with kazal motifs. (974 aa)
	tmem198	Transmembrane protein 198b. (393 aa)
	ilk	Uncharacterized protein. (465 aa)
	LOC103465322	DUF4203 domain-containing protein. (341 aa)
	LOC103480964	Dickkopf_N domain-containing protein. (205 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	ppm1a	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa. (407 aa)
	LOC103464120	RING-type domain-containing protein. (282 aa)
	ENSPREP00000023776	Ring finger protein 220b. (280 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2851 aa)
	LOC103481034	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (401 aa)
	LOC103468446	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
	LOC103479401	Glypican 5c; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (608 aa)
	gid8	GID complex subunit 8 homolog b (S. cerevisiae). (228 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1075 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103469721	Poly [ADP-ribose] polymerase. (1263 aa)
	LOC103470891	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103470892	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (2838 aa)
	zc3h12b	APC membrane recruitment protein 1. (986 aa)
	xiap	X-linked inhibitor of apoptosis. (435 aa)
	ENSPREP00000031676	Glypican 5b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (517 aa)
	LOC103461950	Glypican 5a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (563 aa)
	ENSPREP00000032877	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (330 aa)
	lgr4	Leucine-rich repeat containing G protein-coupled receptor 4. (913 aa)
	LOC103474628	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative). (435 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1357 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000000846	ENSPREP00000023776	ENSPREP00000000846	ENSPREP00000023776	Ring finger protein 220a.	Ring finger protein 220b.	0.900
ENSPREP00000000846	RNF220	ENSPREP00000000846	ENSPREP00000000871	Ring finger protein 220a.	Uncharacterized protein.	0.900
ENSPREP00000023776	ENSPREP00000000846	ENSPREP00000023776	ENSPREP00000000846	Ring finger protein 220b.	Ring finger protein 220a.	0.900
ENSPREP00000023776	LOC103464120	ENSPREP00000023776	ENSPREP00000023754	Ring finger protein 220b.	RING-type domain-containing protein.	0.864
ILK	ilk	ENSPREP00000012407	ENSPREP00000021435	Integrin linked kinase.	Uncharacterized protein.	0.901
LGR5	rspo1	ENSPREP00000008461	ENSPREP00000008831	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 1.	0.937
LOC103457724	LOC103469721	ENSPREP00000018472	ENSPREP00000029282	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.853
LOC103457724	LOC103473565	ENSPREP00000018472	ENSPREP00000008753	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.895
LOC103457724	USP34	ENSPREP00000018472	ENSPREP00000030594	Ring finger protein 146.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.524
LOC103459281	LOC103479069	ENSPREP00000001930	ENSPREP00000009479	Transducin beta like 1 X-linked.	Transducin (beta)-like 1 X-linked receptor 1b.	0.938
LOC103459281	TBL1XR1	ENSPREP00000001930	ENSPREP00000019466	Transducin beta like 1 X-linked.	Transducin beta like 1 X-linked receptor 1.	0.938
LOC103461633	xiap	ENSPREP00000016174	ENSPREP00000031057	Transmembrane protein 198a.	X-linked inhibitor of apoptosis.	0.402
LOC103464120	ENSPREP00000023776	ENSPREP00000023754	ENSPREP00000023776	RING-type domain-containing protein.	Ring finger protein 220b.	0.864
LOC103464120	RNF220	ENSPREP00000023754	ENSPREP00000000871	RING-type domain-containing protein.	Uncharacterized protein.	0.900
LOC103465322	xiap	ENSPREP00000021456	ENSPREP00000031057	DUF4203 domain-containing protein.	X-linked inhibitor of apoptosis.	0.402
LOC103467771	xiap	ENSPREP00000001280	ENSPREP00000031057	DUF4203 domain-containing protein.	X-linked inhibitor of apoptosis.	0.402
LOC103469721	LOC103457724	ENSPREP00000029282	ENSPREP00000018472	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.853
LOC103469721	RNF146	ENSPREP00000029282	ENSPREP00000018985	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.904
LOC103469721	USP34	ENSPREP00000029282	ENSPREP00000030594	Poly [ADP-ribose] polymerase.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.542
LOC103470891	LOC103474475	ENSPREP00000030084	ENSPREP00000028750	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.792