STRINGSTRING
exd3 exd3 zranb3 zranb3 dis3l dis3l LOC103481831 LOC103481831 exd2 exd2 LOC103472437 LOC103472437 prorp prorp cpsf2 cpsf2 LOC103473053 LOC103473053 rpp40 rpp40 dna2 dna2 LOC103480378 LOC103480378 ENSPREP00000014507 ENSPREP00000014507 smg6 smg6 ago4 ago4 tsr1 tsr1 ercc1 ercc1 rbbp8 rbbp8 enpp2 enpp2 dffb dffb LOC103475429 LOC103475429 lrrc27 lrrc27 dis3 dis3 exosc3 exosc3 cstf2 cstf2 exosc10 exosc10 ogg1 ogg1 rexo2 rexo2 ercc4 ercc4 endou endou bivm bivm LOC103481035 LOC103481035 TATDN3 TATDN3 ENSPREP00000025490 ENSPREP00000025490 LOC103482091 LOC103482091 rad1 rad1 mrpl44 mrpl44 LOC103466348 LOC103466348 fen1 fen1 Rpp38 Rpp38 LOC103479911 LOC103479911 ENSPREP00000026599 ENSPREP00000026599 elac1 elac1 cpsf4 cpsf4 LOC103477584 LOC103477584 ENSPREP00000027115 ENSPREP00000027115 LOC103471741 LOC103471741 exo1 exo1 polg polg exosc8 exosc8 mei4 mei4 ddx1 ddx1 isg20l2 isg20l2 dicer1 dicer1 rnaseh1 rnaseh1 dcp2 dcp2 ENSPREP00000018110 ENSPREP00000018110 ENSPREP00000018330 ENSPREP00000018330 ENSPREP00000018356 ENSPREP00000018356 xrn2 xrn2 ENSPREP00000018420 ENSPREP00000018420 ENSPREP00000018476 ENSPREP00000018476 ENSPREP00000018529 ENSPREP00000018529 dnase1l2 dnase1l2 ENSPREP00000018784 ENSPREP00000018784 ENSPREP00000018877 ENSPREP00000018877 ENSPREP00000018907 ENSPREP00000018907 ENSPREP00000018914 ENSPREP00000018914 rad51c rad51c abt1 abt1 ENSPREP00000019399 ENSPREP00000019399 ENSPREP00000019485 ENSPREP00000019485 pld6 pld6 cnot8 cnot8 ENSPREP00000019998 ENSPREP00000019998 pold1 pold1 helz2 helz2 tatdn3 tatdn3 ENSPREP00000020833 ENSPREP00000020833 LOC103461057 LOC103461057 apex1 apex1 trir trir exosc2 exosc2 LOC103464156 LOC103464156 LOC103464155 LOC103464155 ENSPREP00000021617 ENSPREP00000021617 ENSPREP00000021634 ENSPREP00000021634 LOC103461096 LOC103461096 Angel2 Angel2 EME2 EME2 nudt12 nudt12 LACTB2 LACTB2 n4bp1 n4bp1 ENSPREP00000028080 ENSPREP00000028080 rag1 rag1 pld3 pld3 angel1 angel1 ENSPREP00000028517 ENSPREP00000028517 ercc2 ercc2 LOC103480695 LOC103480695 exd1 exd1 hormad1 hormad1 pan3 pan3 piwil2 piwil2 znrd1 znrd1 fancm fancm rrs1 rrs1 dbr1 dbr1 pop5 pop5 zc3h12d zc3h12d tut1 tut1 zc3h12b-2 zc3h12b-2 LOC103466190 LOC103466190 LOC103463801 LOC103463801 ercc3 ercc3 POP1 POP1 RIDA RIDA Ttc38 Ttc38 tatdn1 tatdn1 tsen2 tsen2 xrn1 xrn1 nol9 nol9 edc4 edc4 LOC103472797 LOC103472797 Pld4 Pld4 dclre1c dclre1c LOC103472796 LOC103472796 ENSPREP00000032147 ENSPREP00000032147 ercc5 ercc5 ENSPREP00000032209 ENSPREP00000032209 rexo4 rexo4 rpp14 rpp14 LOC103470954 LOC103470954 kri1 kri1 LOC103477484 LOC103477484 LOC103457156 LOC103457156 ENSPREP00000022135 ENSPREP00000022135 fan1 fan1 LOC103467187 LOC103467187 rnaseh2a rnaseh2a pop7 pop7 meiob meiob mus81 mus81 ENSPREP00000023734 ENSPREP00000023734 edc3 edc3 endog endog eri2 eri2 REXO5 REXO5 parn parn xpa xpa ENSPREP00000000500 ENSPREP00000000500 nthl1 nthl1 MARF1 MARF1 ENSPREP00000000945 ENSPREP00000000945 dcp1a dcp1a ybey ybey pan2 pan2 LOC103466231 LOC103466231 atad5 atad5 rpp30 rpp30 LOC103463886 LOC103463886 LOC103478280 LOC103478280 Pcf11 Pcf11 ccdc36 ccdc36 piwil1 piwil1 LOC103472230 LOC103472230 exosc9 exosc9 rnasek rnasek snd1 snd1 utp23 utp23 LOC103472818 LOC103472818 dis3l2 dis3l2 ENSPREP00000003495 ENSPREP00000003495 LOC103480902 LOC103480902 bms1 bms1 gnl3 gnl3 ENDOV ENDOV PNPT1 PNPT1 elac2 elac2 mblac1 mblac1 tsn tsn cnot6l cnot6l LOC103471032 LOC103471032 LOC103471263 LOC103471263 ASTE1 ASTE1 polr2i polr2i dcp1b dcp1b LOC103480107 LOC103480107 aptx aptx cpsf6 cpsf6 CPSF3 CPSF3 tdp1 tdp1 ENSPREP00000006649 ENSPREP00000006649 ENSPREP00000006911 ENSPREP00000006911 aplf aplf Nhp2 Nhp2 LOC103475362 LOC103475362 zc3h12a zc3h12a ENSPREP00000007951 ENSPREP00000007951 ENSPREP00000007955 ENSPREP00000007955 ENSPREP00000008065 ENSPREP00000008065 LOC103466673 LOC103466673 ENSPREP00000008142 ENSPREP00000008142 ENSPREP00000008270 ENSPREP00000008270 ENSPREP00000008430 ENSPREP00000008430 Isg20 Isg20 ENSPREP00000008710 ENSPREP00000008710 rad50 rad50 CNOT2 CNOT2 LOC103466956 LOC103466956 ern1 ern1 LOC103477773 LOC103477773 DXO DXO LOC103477771 LOC103477771 mgme1 mgme1 LOC103460045 LOC103460045 noct noct ENSPREP00000010179 ENSPREP00000010179 LOC103479103 LOC103479103 LOC103479102 LOC103479102 ankle1 ankle1 clg5h12orf10 clg5h12orf10 nob1 nob1 tdp2 tdp2 polr3k polr3k LOC103474844 LOC103474844 nop9 nop9 drosha drosha pop4 pop4 POLE POLE ENSPREP00000033302 ENSPREP00000033302 dclre1a dclre1a mre11 mre11 eri1 eri1 dclre1b dclre1b rrp36 rrp36 pde12 pde12 LOC103464337 LOC103464337 CPSF7 CPSF7 pelo pelo rcl1 rcl1 spo11 spo11 LOC103457410 LOC103457410
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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exd3Exonuclease 3'-5' domain containing 3. (890 aa)
zranb3Zinc finger, RAN-binding domain containing 3. (1098 aa)
dis3lDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (974 aa)
LOC103481831Uncharacterized protein. (187 aa)
exd2Exonuclease 3'-5' domain containing 2. (644 aa)
LOC103472437Reactive intermediate imine deaminase A homolog. (137 aa)
prorpProtein only RNase P catalytic subunit. (577 aa)
cpsf2Cleavage and polyadenylation specificity factor subunit 2. (787 aa)
LOC103473053Uncharacterized protein; Belongs to the argonaute family. (695 aa)
rpp40Ribonuclease P/MRP 40 subunit. (348 aa)
dna2Uncharacterized protein. (1328 aa)
LOC103480378KH and NYN domain containing. (1015 aa)
ENSPREP00000014507UBA_6 domain-containing protein. (200 aa)
smg6SMG6 nonsense mediated mRNA decay factor. (1607 aa)
ago4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (913 aa)
tsr1TSR1 ribosome maturation factor. (850 aa)
ercc1Excision repair cross-complementation group 1. (358 aa)
rbbp8Uncharacterized protein. (647 aa)
enpp2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (828 aa)
dffbDNA fragmentation factor, beta polypeptide (caspase-activated DNase). (346 aa)
LOC103475429C3H1-type domain-containing protein. (931 aa)
lrrc27Uncharacterized protein. (407 aa)
dis3DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (951 aa)
exosc3Exosome component 3. (273 aa)
cstf2Cleavage stimulation factor, 3' pre-RNA, subunit 2. (556 aa)
exosc10Exosome component 10. (892 aa)
ogg18-oxoguanine DNA glycosylase. (388 aa)
rexo2Small fragment nuclease. (280 aa)
ercc4Excision repair cross-complementation group 4. (893 aa)
endouEndonuclease, polyU-specific. (381 aa)
bivmBasic, immunoglobulin-like variable motif containing. (500 aa)
LOC103481035Si:ch211-141o9.10. (250 aa)
TATDN3TatD DNase domain containing 3. (268 aa)
ENSPREP00000025490XPG_I_2 domain-containing protein. (433 aa)
LOC103482091Essential meiotic structure-specific endonuclease 1. (232 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
mrpl44Mitochondrial ribosomal protein L44. (331 aa)
LOC103466348Endonuclease, polyU-specific C. (315 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (396 aa)
Rpp38Ribonuclease P/MRP 38 subunit. (278 aa)
LOC103479911Si:dkey-222f8.3. (269 aa)
ENSPREP00000026599Exosome component 7. (210 aa)
elac1ElaC ribonuclease Z 1. (372 aa)
cpsf4Cleavage and polyadenylation specific factor 4. (262 aa)
LOC103477584Deoxyribonuclease II, lysosomal. (376 aa)
ENSPREP00000027115Uncharacterized protein. (207 aa)
LOC103471741Uncharacterized protein. (297 aa)
exo1Exonuclease 1. (757 aa)
polgPolymerase (DNA directed), gamma. (1253 aa)
exosc8Exosome component 8. (279 aa)
mei4Meiotic double-stranded break formation protein 4. (376 aa)
ddx1DEAD (Asp-Glu-Ala-Asp) box helicase 1. (740 aa)
isg20l2Interferon stimulated exonuclease gene 20 like 2. (348 aa)
dicer1Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1860 aa)
rnaseh1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (301 aa)
dcp2Decapping mRNA 2. (398 aa)
ENSPREP00000018110Uncharacterized protein. (378 aa)
ENSPREP00000018330RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (150 aa)
ENSPREP00000018356TatD DNase domain containing 2. (697 aa)
xrn25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (943 aa)
ENSPREP00000018420Uncharacterized protein. (1121 aa)
ENSPREP00000018476RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (153 aa)
ENSPREP00000018529FIP1 like 1b (S. cerevisiae). (435 aa)
dnase1l2Deoxyribonuclease I. (328 aa)
ENSPREP00000018784Uncharacterized protein. (565 aa)
ENSPREP00000018877RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (121 aa)
ENSPREP00000018907RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (140 aa)
ENSPREP00000018914RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (131 aa)
rad51cRAD51 paralog C. (377 aa)
abt1Activator of basal transcription 1. (274 aa)
ENSPREP00000019399Uncharacterized protein. (132 aa)
ENSPREP00000019485Uncharacterized protein. (154 aa)
pld6Phospholipase D family, member 6. (211 aa)
cnot8CCR4-NOT transcription complex, subunit 8. (285 aa)
ENSPREP00000019998Exonuclease domain-containing protein. (263 aa)
pold1DNA polymerase. (1102 aa)
helz2C3H1-type domain-containing protein. (2437 aa)
tatdn3TatD DNase domain containing 3. (278 aa)
ENSPREP00000020833Ribonuclease T2; Belongs to the RNase T2 family. (166 aa)
LOC103461057SET domain and mariner transposase fusion gene. (292 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (311 aa)
trirTelomerase RNA component interacting RNase. (148 aa)
exosc2Exosome component 2. (293 aa)
LOC103464156Deoxyribonuclease II beta. (352 aa)
LOC103464155Uncharacterized protein. (245 aa)
ENSPREP00000021617RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (130 aa)
ENSPREP00000021634RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (128 aa)
LOC103461096PINc domain-containing protein. (704 aa)
Angel2Endo/exonuclease/phosphatase domain-containing protein. (374 aa)
EME2ERCC4 domain-containing protein. (370 aa)
nudt12Nudix (nucleoside diphosphate linked moiety X)-type motif 12. (462 aa)
LACTB2Lactamase beta 2. (318 aa)
n4bp1Nedd4 binding protein 1. (818 aa)
ENSPREP00000028080Piwi domain-containing protein. (177 aa)
rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (994 aa)
pld3Phospholipase D family, member 3. (446 aa)
angel1Angel homolog 1 (Drosophila). (712 aa)
ENSPREP00000028517ANK_REP_REGION domain-containing protein. (336 aa)
ercc2Excision repair cross-complementation group 2. (655 aa)
LOC103480695Protein kinase domain-containing protein. (356 aa)
exd13'-5' exonuclease domain-containing protein. (520 aa)
hormad1HORMA domain containing 1. (372 aa)
pan3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (792 aa)
piwil2Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (1055 aa)
znrd1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (118 aa)
fancmUncharacterized protein. (1901 aa)
rrs1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (308 aa)
dbr1Debranching RNA lariats 1. (538 aa)
pop5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (167 aa)
zc3h12dC3H1-type domain-containing protein. (570 aa)
tut1Terminal uridylyl transferase 1, U6 snRNA-specific. (777 aa)
zc3h12b-2Zinc finger CCCH-type containing 12B. (856 aa)
LOC103466190CCR4-NOT transcription complex, subunit 2. (660 aa)
LOC103463801Ribonuclease P 21 subunit. (157 aa)
ercc3Excision repair cross-complementation group 3. (783 aa)
POP1POP1 homolog, ribonuclease P/MRP subunit. (960 aa)
RIDAReactive intermediate imine deaminase A homolog. (136 aa)
Ttc38Uncharacterized protein. (121 aa)
tatdn1TatD DNase domain containing 1. (314 aa)
tsen2Uncharacterized protein. (306 aa)
xrn15'-3' exoribonuclease 1. (1705 aa)
nol9Nucleolar protein 9. (699 aa)
edc4Enhancer of mRNA decapping 4. (1333 aa)
LOC103472797Uncharacterized protein. (1066 aa)
Pld4Uncharacterized protein. (71 aa)
dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (576 aa)
LOC103472796Uncharacterized protein. (855 aa)
ENSPREP00000032147tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (281 aa)
ercc5Excision repair cross-complementation group 5. (980 aa)
ENSPREP00000032209Uncharacterized protein. (235 aa)
rexo4REX4 homolog, 3'-5' exonuclease. (413 aa)
rpp14Ribonuclease P/MRP 14 subunit. (133 aa)
LOC103470954CCR4-NOT transcription complex, subunit 7. (286 aa)
kri1KRI1 homolog. (752 aa)
LOC103477484XPGN domain-containing protein. (667 aa)
LOC103457156Cleavage and polyadenylation specific factor 3. (627 aa)
ENSPREP00000022135Uncharacterized protein. (78 aa)
fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (941 aa)
LOC103467187Deoxyribonuclease; Belongs to the DNase I family. (288 aa)
rnaseh2aRibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (296 aa)
pop7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (151 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
mus81MUS81 structure-specific endonuclease subunit. (616 aa)
ENSPREP00000023734Uncharacterized protein. (112 aa)
edc3Enhancer of mRNA decapping 3 homolog (S. cerevisiae). (478 aa)
endogEndonuclease. (300 aa)
eri2Exonuclease domain-containing protein. (255 aa)
REXO5RNA exonuclease 5. (806 aa)
parnPoly(A)-specific ribonuclease (deadenylation nuclease). (683 aa)
xpaXeroderma pigmentosum, complementation group A. (275 aa)
ENSPREP00000000500Uncharacterized protein. (272 aa)
nthl1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (452 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1791 aa)
ENSPREP00000000945Uncharacterized protein. (163 aa)
dcp1aDecapping mRNA 1A. (491 aa)
ybeyYbeY metalloendoribonuclease. (168 aa)
pan2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1211 aa)
LOC103466231U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (247 aa)
atad5ATPase family AAA domain containing 5a. (1822 aa)
rpp30Ribonuclease P/MRP 30 subunit. (287 aa)
LOC103463886Nocturnin. (385 aa)
LOC103478280C3H1-type domain-containing protein. (884 aa)
Pcf11CID domain-containing protein. (87 aa)
ccdc36Uncharacterized protein. (429 aa)
piwil1Piwi-like RNA-mediated gene silencing 1; Belongs to the argonaute family. (840 aa)
LOC103472230Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (894 aa)
exosc9Exosome component 9. (461 aa)
rnasekRibonuclease, RNase K b. (101 aa)
snd1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (911 aa)
utp23UTP23 small subunit processome component. (255 aa)
LOC103472818Uncharacterized protein. (366 aa)
dis3l2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1060 aa)
ENSPREP00000003495Uncharacterized protein. (312 aa)
LOC103480902Si:ch211-133n4.4. (342 aa)
bms1BMS1 ribosome biogenesis factor. (1311 aa)
gnl3Guanine nucleotide binding protein-like 3 (nucleolar). (521 aa)
ENDOVEndonuclease V. (220 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (728 aa)
elac2ElaC ribonuclease Z 2. (838 aa)
mblac1Metallo-beta-lactamase domain containing 1. (216 aa)
tsnTranslin. (227 aa)
cnot6lCCR4-NOT transcription complex, subunit 6-like. (555 aa)
LOC103471032Phospholipase D family, member 7. (636 aa)
LOC103471263CCR4-NOT transcription complex, subunit 6a. (550 aa)
ASTE1Asteroid homolog 1. (676 aa)
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
dcp1bDecapping mRNA 1B. (631 aa)
LOC103480107Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa)
aptxAprataxin. (303 aa)
cpsf6Cleavage and polyadenylation specific factor 6. (586 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (653 aa)
tdp1Tyrosyl-DNA phosphodiesterase 1. (622 aa)
ENSPREP00000006649Reverse transcriptase domain-containing protein. (112 aa)
ENSPREP00000006911Uncharacterized protein. (216 aa)
aplfUncharacterized protein. (302 aa)
Nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (117 aa)
LOC103475362Endonuclease, polyU-specific 2. (283 aa)
zc3h12aZinc finger CCCH-type containing 12A. (623 aa)
ENSPREP00000007951Uncharacterized protein. (113 aa)
ENSPREP00000007955Uncharacterized protein. (1154 aa)
ENSPREP00000008065Uncharacterized protein. (114 aa)
LOC103466673Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1001 aa)
ENSPREP00000008142Uncharacterized protein. (135 aa)
ENSPREP00000008270WD_REPEATS_REGION domain-containing protein. (129 aa)
ENSPREP00000008430Uncharacterized protein. (1091 aa)
Isg20Interferon stimulated exonuclease gene. (218 aa)
ENSPREP00000008710Ribonuclease P and MRP subunit p25, b. (222 aa)
rad50RAD50 homolog, double strand break repair protein. (1355 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (522 aa)
LOC103466956Deoxyribonuclease; Belongs to the DNase I family. (299 aa)
ern1Endoplasmic reticulum to nucleus signaling 1. (1060 aa)
LOC103477773Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
DXODecapping exoribonuclease. (258 aa)
LOC103477771Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (867 aa)
mgme1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family. (350 aa)
LOC103460045Ribonuclease T2, like; Belongs to the RNase T2 family. (269 aa)
noctNocturnin. (445 aa)
ENSPREP00000010179Uncharacterized protein. (111 aa)
LOC103479103Zgc:110269. (322 aa)
LOC103479102Uncharacterized protein. (214 aa)
ankle1Zgc:85936. (834 aa)
clg5h12orf10Melanocyte proliferating gene 1. (333 aa)
nob1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (457 aa)
tdp2Tyrosyl-DNA phosphodiesterase 2b. (359 aa)
polr3kDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
LOC103474844Si:dkey-243k1.3. (313 aa)
nop9Uncharacterized protein. (686 aa)
droshaDrosha ribonuclease III. (1312 aa)
pop4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (231 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
ENSPREP00000033302DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (361 aa)
dclre1aDNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (895 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)
eri1Exoribonuclease 1. (340 aa)
dclre1bDNA cross-link repair 1B. (566 aa)
rrp36Ribosomal RNA processing 36. (349 aa)
pde12Phosphodiesterase 12. (586 aa)
LOC103464337Deoxyribonuclease; Belongs to the DNase I family. (269 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (451 aa)
peloProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
rcl1RNA terminal phosphate cyclase-like 1. (372 aa)
spo11SPO11 initiator of meiotic double stranded breaks. (379 aa)
LOC103457410Ectonucleotide pyrophosphatase/phosphodiesterase 1. (834 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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