(13 nodes) Regulation of DNA methylation-dependent heterochromatin assembly network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103467505	Transcription activation suppressor b. (1474 aa)
	tasor	DUF3715 domain-containing protein. (1922 aa)
	LOC103457816	Uncharacterized protein. (606 aa)
	morc2	MORC family CW-type zinc finger 2. (1050 aa)
	ENSPREP00000001668	ANK_REP_REGION domain-containing protein. (254 aa)
	mphosph8	Chromo domain-containing protein. (1294 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
	dnmt1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1508 aa)
	aicda	Activation-induced cytidine deaminase. (211 aa)
	atf7ip	Activating transcription factor 7 interacting protein. (958 aa)
	LOC103461003	SAM domain-containing protein. (417 aa)
	setdb1	SET domain bifurcated histone lysine methyltransferase 1b. (1261 aa)
	atf7ip2	Fibronectin type-III domain-containing protein. (381 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001668	LOC103457816	ENSPREP00000001668	ENSPREP00000033253	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.558
ENSPREP00000001668	LOC103467505	ENSPREP00000001668	ENSPREP00000025877	ANK_REP_REGION domain-containing protein.	Transcription activation suppressor b.	0.513
ENSPREP00000001668	mphosph8	ENSPREP00000001668	ENSPREP00000001684	ANK_REP_REGION domain-containing protein.	Chromo domain-containing protein.	0.918
ENSPREP00000001668	setdb1	ENSPREP00000001668	ENSPREP00000025862	ANK_REP_REGION domain-containing protein.	SET domain bifurcated histone lysine methyltransferase 1b.	0.558
ENSPREP00000001668	tasor	ENSPREP00000001668	ENSPREP00000033619	ANK_REP_REGION domain-containing protein.	DUF3715 domain-containing protein.	0.513
LOC103457816	ENSPREP00000001668	ENSPREP00000033253	ENSPREP00000001668	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.558
LOC103457816	atf7ip	ENSPREP00000033253	ENSPREP00000018896	Uncharacterized protein.	Activating transcription factor 7 interacting protein.	0.897
LOC103457816	atf7ip2	ENSPREP00000033253	ENSPREP00000028137	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.897
LOC103457816	dnmt1	ENSPREP00000033253	ENSPREP00000009697	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.466
LOC103457816	kdm1a	ENSPREP00000033253	ENSPREP00000006670	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.422
LOC103457816	mphosph8	ENSPREP00000033253	ENSPREP00000001684	Uncharacterized protein.	Chromo domain-containing protein.	0.558
LOC103467505	ENSPREP00000001668	ENSPREP00000025877	ENSPREP00000001668	Transcription activation suppressor b.	ANK_REP_REGION domain-containing protein.	0.513
LOC103467505	mphosph8	ENSPREP00000025877	ENSPREP00000001684	Transcription activation suppressor b.	Chromo domain-containing protein.	0.513
atf7ip	LOC103457816	ENSPREP00000018896	ENSPREP00000033253	Activating transcription factor 7 interacting protein.	Uncharacterized protein.	0.897
atf7ip	setdb1	ENSPREP00000018896	ENSPREP00000025862	Activating transcription factor 7 interacting protein.	SET domain bifurcated histone lysine methyltransferase 1b.	0.897
atf7ip2	LOC103457816	ENSPREP00000028137	ENSPREP00000033253	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.897
atf7ip2	setdb1	ENSPREP00000028137	ENSPREP00000025862	Fibronectin type-III domain-containing protein.	SET domain bifurcated histone lysine methyltransferase 1b.	0.897
dnmt1	LOC103457816	ENSPREP00000009697	ENSPREP00000033253	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.466
dnmt1	kdm1a	ENSPREP00000009697	ENSPREP00000006670	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.749
dnmt1	setdb1	ENSPREP00000009697	ENSPREP00000025862	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	SET domain bifurcated histone lysine methyltransferase 1b.	0.466