(55 nodes) Cellular response to alcohol network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103475891	Apoptosis inducing factor mitochondrion associated 1. (597 aa)
	ptgir	Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	brca1	Uncharacterized protein. (1344 aa)
	LOC103459297	Uncharacterized protein. (285 aa)
	LOC103467316	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
	ptger4	Prostaglandin E receptor 4 (subtype EP4) b. (456 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (637 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	xrn1	5'-3' exoribonuclease 1. (1705 aa)
	mlc1	Modulator of VRAC current 1. (404 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (321 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	LOC103475853	Pyr_redox_2 domain-containing protein. (552 aa)
	ENSPREP00000030584	Cytochrome P450, family 1, subfamily C, polypeptide 2. (479 aa)
	gramd1c	GRAM domain containing 1c. (657 aa)
	adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1121 aa)
	LOC103465321	Junction plakoglobin a. (721 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (298 aa)
	LOC103469641	Golgi phosphoprotein 3. (245 aa)
	LOC103466076	Uncharacterized protein. (354 aa)
	recql5	RecQ helicase-like 5. (1020 aa)
	LOC103457903	Homeobox domain-containing protein. (307 aa)
	ENSPREP00000022608	GRAM domain-containing protein. (223 aa)
	ENSPREP00000022389	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	LOC103459627	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (517 aa)
	podn	Podocan. (587 aa)
	LOC103471530	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	LOC103460973	Prostaglandin E receptor 2a (subtype EP2); Belongs to the G-protein coupled receptor 1 family. (389 aa)
	LOC103457694	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	otx2	Orthodenticle homeobox 2b. (290 aa)
	ptgfr	Prostaglandin F receptor (FP). (364 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	LOC103463403	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1126 aa)
	SPIDR	Scaffold protein involved in DNA repair. (934 aa)
	ENSPREP00000012469	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (487 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (446 aa)
	blm	BLM RecQ like helicase. (1399 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1172 aa)
	ENSPREP00000008810	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (962 aa)
	gramd1b	GRAM domain containing 1Bb. (926 aa)
	glra3	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (468 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (616 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
	LOC103480139	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	golph3	Si:dkey-27b3.2. (294 aa)
	LOC103477101	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (536 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1502 aa)
	ENSPREP00000003132	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	LOC103467741	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1451 aa)
	glra2	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (523 aa)
	rad51	RAD51 recombinase. (219 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
	LOC103475890	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000008810	LOC103457562	ENSPREP00000008810	ENSPREP00000001452	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.438
ENSPREP00000008810	LOC103457694	ENSPREP00000008810	ENSPREP00000017816	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.470
ENSPREP00000008810	LOC103467316	ENSPREP00000008810	ENSPREP00000032696	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.416
ENSPREP00000008810	LOC103481184	ENSPREP00000008810	ENSPREP00000015196	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.443
ENSPREP00000008810	adcy5	ENSPREP00000008810	ENSPREP00000004353	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.413
ENSPREP00000008810	adcy6	ENSPREP00000008810	ENSPREP00000010286	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.414
ENSPREP00000008810	adcy8	ENSPREP00000008810	ENSPREP00000030665	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.434
ENSPREP00000012469	LOC103460973	ENSPREP00000012469	ENSPREP00000018525	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E receptor 2a (subtype EP2); Belongs to the G-protein coupled receptor 1 family.	0.539
ENSPREP00000012469	ptgir	ENSPREP00000012469	ENSPREP00000033838	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family.	0.436
ENSPREP00000022389	LOC103460973	ENSPREP00000022389	ENSPREP00000018525	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E receptor 2a (subtype EP2); Belongs to the G-protein coupled receptor 1 family.	0.561
ENSPREP00000022389	ptgir	ENSPREP00000022389	ENSPREP00000033838	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family.	0.436
LOC103457562	ENSPREP00000008810	ENSPREP00000001452	ENSPREP00000008810	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.438
LOC103457562	LOC103457694	ENSPREP00000001452	ENSPREP00000017816	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.473
LOC103457562	LOC103459297	ENSPREP00000001452	ENSPREP00000032742	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.768
LOC103457562	LOC103463403	ENSPREP00000001452	ENSPREP00000014016	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.440
LOC103457562	LOC103466076	ENSPREP00000001452	ENSPREP00000025204	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.768
LOC103457562	LOC103467316	ENSPREP00000001452	ENSPREP00000032696	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.433
LOC103457562	adcy3	ENSPREP00000001452	ENSPREP00000027340	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.451
LOC103457562	adcy5	ENSPREP00000001452	ENSPREP00000004353	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.420
LOC103457562	adcy6	ENSPREP00000001452	ENSPREP00000010286	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429