(95 nodes) Photoreceptor cell cilium network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tbcc	Tubulin folding cofactor C. (343 aa)
	ENSPREP00000002127	RabBD domain-containing protein. (192 aa)
	LOC103465677	Guanylate cyclase. (954 aa)
	LOC103464572	Rhodopsin. (345 aa)
	LOC103464571	Rhodopsin. (362 aa)
	opn3	Opsin 3. (490 aa)
	kifap3	Kinesin-associated protein 3a. (745 aa)
	pde6g	Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a. (90 aa)
	rcvrn	Recoverin a. (203 aa)
	LOC103481790	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (251 aa)
	gnat1	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1. (350 aa)
	cerkl	Ceramide kinase-like. (529 aa)
	guca1b	Guanylate cyclase activator 1B. (211 aa)
	pcare	Uncharacterized protein. (1131 aa)
	LOC103474780	Guanylate cyclase. (1100 aa)
	Topors	RING-type domain-containing protein. (88 aa)
	ENSPREP00000008634	Uncharacterized protein. (690 aa)
	LOC103461390	Uncharacterized protein. (82 aa)
	LOC103480256	Guanylate cyclase. (1136 aa)
	bbs4	Bardet-Biedl syndrome 4. (520 aa)
	LOC103459922	Guanylate cyclase activator 1d. (178 aa)
	ttc8	Tetratricopeptide repeat domain 8. (513 aa)
	rpgr	Uncharacterized protein. (1381 aa)
	fam161b	FAM161 centrosomal protein B. (555 aa)
	nphp4	Uncharacterized protein. (1207 aa)
	ENSPREP00000015938	Nephronophthisis 4. (230 aa)
	LOC103482329	Cyclic nucleotide gated channel beta 3, tandem duplicate 1. (746 aa)
	LOC103482304	Cyclic nucleotide gated channel beta 3, tandem duplicate 2. (597 aa)
	LOC103457654	Lebercilin LCA5. (811 aa)
	LOC103458995	Peripherin 2-like a. (366 aa)
	rrh	Retinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	ENSPREP00000017400	SEA domain-containing protein. (1271 aa)
	ush2a	Usher syndrome 2A (autosomal recessive, mild). (4818 aa)
	LOC103463303	Crumbs cell polarity complex component 1. (1334 aa)
	rgs9bp	Regulator of G protein signaling 9 binding protein. (225 aa)
	crb2	Crumbs cell polarity complex component 2b. (1343 aa)
	LOC103473166	Uncharacterized protein. (1465 aa)
	LOC103457115	Uncharacterized protein. (356 aa)
	LOC103477409	Peripherin 2b (retinal degeneration, slow). (344 aa)
	cetn3	Uncharacterized protein. (198 aa)
	ENSPREP00000020403	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (157 aa)
	Kif17	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (241 aa)
	LOC103479813	Si:ch211-106h4.9. (986 aa)
	LOC103479309	Kinesin-associated protein 3b. (807 aa)
	LOC103480551	RPGR interacting protein 1. (1005 aa)
	LOC103473803	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (220 aa)
	LOC103467179	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2. (350 aa)
	RHO	Extra-ocular rhodopsin. (391 aa)
	LOC103480989	RING-type domain-containing protein. (1438 aa)
	rom1	Retinal outer segment membrane protein 1b. (361 aa)
	rho	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (350 aa)
	ENSPREP00000024139	RP1 axonemal microtubule associated. (235 aa)
	LOC103469622	Whirlin b. (978 aa)
	LOC103466075	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1538 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (404 aa)
	LOC103476853	Retinal G protein coupled receptor a; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa)
	ift140	Intraflagellar transport 140 homolog (Chlamydomonas). (1435 aa)
	ENSPREP00000028127	Doublecortin domain-containing protein. (4436 aa)
	lyar	Ly1 antibody reactive homolog (mouse). (322 aa)
	opn1sw	G_PROTEIN_RECEP_F1_2 domain-containing protein. (336 aa)
	pex6	Peroxisomal biogenesis factor 6. (1057 aa)
	rpgrip1l	RPGRIP1 like. (1044 aa)
	fam161a	FAM161 centrosomal protein A. (641 aa)
	LOC103458000	Uncharacterized protein. (900 aa)
	whrn	Whirlin a. (828 aa)
	LOC103458803	Interphotoreceptor matrix proteoglycan 1. (967 aa)
	cfap410	Cilia and flagella associated protein 410. (252 aa)
	LOC103465544	G_PROTEIN_RECEP_F1_2 domain-containing protein. (356 aa)
	guca1a	Guanylate cyclase activator 1A. (182 aa)
	LOC103465586	G_PROTEIN_RECEP_F1_2 domain-containing protein. (360 aa)
	LOC103465546	G_PROTEIN_RECEP_F1_2 domain-containing protein. (356 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1287 aa)
	LOC103465548	Opsin 1 (cone pigments), short-wave-sensitive 2. (354 aa)
	LOC103465549	Opsin 1 (cone pigments), short-wave-sensitive 2. (351 aa)
	iqcb1	Uncharacterized protein. (369 aa)
	LOC103475785	Guanylate cyclase. (1151 aa)
	ENSPREP00000001490	Si:dkey-44k1.5. (683 aa)
	LOC103472858	Recoverin 3. (192 aa)
	nxnl1	Nucleoredoxin like 1. (235 aa)
	LOC103463115	Nucleoredoxin like 1. (232 aa)
	LOC103471875	Centrin 4. (171 aa)
	ENSPREP00000009710	Uncharacterized protein. (2328 aa)
	cetn2	Centrin, EF-hand protein, 2. (200 aa)
	bbs7	Bardet-Biedl syndrome 7. (712 aa)
	LOC103477278	G_PROTEIN_RECEP_F1_2 domain-containing protein. (410 aa)
	wdr19	WD repeat domain 19. (1343 aa)
	rd3	Retinal degeneration 3, GUCY2D regulator. (215 aa)
	bsg	Basigin. (390 aa)
	spata7	Uncharacterized protein. (583 aa)
	rp1l1	Rp1 like 1a. (2396 aa)
	LOC103478050	Recoverin 2. (193 aa)
	LOC103457389	Long wave sensitive-4 opsin. (357 aa)
	cngb1	Cyclic nucleotide gated channel beta 1a. (851 aa)
	LOC103482275	Regulator of G protein signaling 9 binding protein. (261 aa)
	prph2	Peripherin 2a (retinal degeneration, slow). (344 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001490	LOC103459922	ENSPREP00000001490	ENSPREP00000002113	Si:dkey-44k1.5.	Guanylate cyclase activator 1d.	0.532
ENSPREP00000001490	LOC103467179	ENSPREP00000001490	ENSPREP00000021938	Si:dkey-44k1.5.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.514
ENSPREP00000001490	LOC103472858	ENSPREP00000001490	ENSPREP00000000802	Si:dkey-44k1.5.	Recoverin 3.	0.421
ENSPREP00000001490	LOC103478050	ENSPREP00000001490	ENSPREP00000013015	Si:dkey-44k1.5.	Recoverin 2.	0.421
ENSPREP00000001490	gnat1	ENSPREP00000001490	ENSPREP00000005925	Si:dkey-44k1.5.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.514
ENSPREP00000001490	guca1a	ENSPREP00000001490	ENSPREP00000032624	Si:dkey-44k1.5.	Guanylate cyclase activator 1A.	0.505
ENSPREP00000001490	guca1b	ENSPREP00000001490	ENSPREP00000007120	Si:dkey-44k1.5.	Guanylate cyclase activator 1B.	0.527
ENSPREP00000001490	rcvrn	ENSPREP00000001490	ENSPREP00000004734	Si:dkey-44k1.5.	Recoverin a.	0.431
ENSPREP00000015938	LOC103480551	ENSPREP00000015938	ENSPREP00000021389	Nephronophthisis 4.	RPGR interacting protein 1.	0.796
ENSPREP00000015938	ift140	ENSPREP00000015938	ENSPREP00000027530	Nephronophthisis 4.	Intraflagellar transport 140 homolog (Chlamydomonas).	0.440
ENSPREP00000015938	iqcb1	ENSPREP00000015938	ENSPREP00000033130	Nephronophthisis 4.	Uncharacterized protein.	0.500
ENSPREP00000015938	nphp4	ENSPREP00000015938	ENSPREP00000015922	Nephronophthisis 4.	Uncharacterized protein.	0.899
ENSPREP00000015938	rpgr	ENSPREP00000015938	ENSPREP00000015095	Nephronophthisis 4.	Uncharacterized protein.	0.608
ENSPREP00000015938	rpgrip1l	ENSPREP00000015938	ENSPREP00000030453	Nephronophthisis 4.	RPGRIP1 like.	0.919
ENSPREP00000020403	Kif17	ENSPREP00000020403	ENSPREP00000020430	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.925
ENSPREP00000020403	LOC103479309	ENSPREP00000020403	ENSPREP00000021322	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-associated protein 3b.	0.516
ENSPREP00000020403	ift52	ENSPREP00000020403	ENSPREP00000026083	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Intraflagellar transport 52 homolog (Chlamydomonas).	0.552
ENSPREP00000020403	kifap3	ENSPREP00000020403	ENSPREP00000004180	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-associated protein 3a.	0.516
ENSPREP00000020403	wdr19	ENSPREP00000020403	ENSPREP00000010759	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	WD repeat domain 19.	0.456
ENSPREP00000028127	guca1a	ENSPREP00000028127	ENSPREP00000032624	Doublecortin domain-containing protein.	Guanylate cyclase activator 1A.	0.408