(14 nodes) Regulation of action potential network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pawr	PRKC, apoptosis, WT1, regulator. (280 aa)
	LOC103465321	Junction plakoglobin a. (721 aa)
	gja5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (376 aa)
	Cav1	Uncharacterized protein. (84 aa)
	fmr1	Fragile X mental retardation 1. (273 aa)
	tmem161b	Transmembrane protein 161B. (492 aa)
	LOC103476588	Uncharacterized protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. (336 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	LOC103461055	Fragile X mental retardation 1. (400 aa)
	RNF207	Ring finger protein 207a. (564 aa)
	ENSPREP00000022871	PKD domain-containing protein. (262 aa)
	ENSPREP00000026191	Glucosylceramidase. (147 aa)
	Gba	Glucosylceramidase. (291 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cav1	LOC103465321	ENSPREP00000003891	ENSPREP00000000600	Uncharacterized protein.	Junction plakoglobin a.	0.458
Cav1	cav3	ENSPREP00000003891	ENSPREP00000013872	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.544
ENSPREP00000026191	Gba	ENSPREP00000026191	ENSPREP00000026205	Glucosylceramidase.	Glucosylceramidase.	0.926
Gba	ENSPREP00000026191	ENSPREP00000026205	ENSPREP00000026191	Glucosylceramidase.	Glucosylceramidase.	0.926
LOC103461055	fmr1	ENSPREP00000020915	ENSPREP00000004643	Fragile X mental retardation 1.	Fragile X mental retardation 1.	0.932
LOC103465217	LOC103465321	ENSPREP00000013910	ENSPREP00000000600	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.458
LOC103465217	cav3	ENSPREP00000013910	ENSPREP00000013872	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.955
LOC103465321	Cav1	ENSPREP00000000600	ENSPREP00000003891	Junction plakoglobin a.	Uncharacterized protein.	0.458
LOC103465321	LOC103465217	ENSPREP00000000600	ENSPREP00000013910	Junction plakoglobin a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.458
LOC103465321	cav3	ENSPREP00000000600	ENSPREP00000013872	Junction plakoglobin a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.536
cav3	Cav1	ENSPREP00000013872	ENSPREP00000003891	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.544
cav3	LOC103465217	ENSPREP00000013872	ENSPREP00000013910	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.955
cav3	LOC103465321	ENSPREP00000013872	ENSPREP00000000600	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.536
fmr1	LOC103461055	ENSPREP00000004643	ENSPREP00000020915	Fragile X mental retardation 1.	Fragile X mental retardation 1.	0.932