(34 nodes) Integral component of presynaptic membrane network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000034105	Proline-rich transmembrane protein 2. (159 aa)
	NCSTN	Nicastrin. (699 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
	LOC103465674	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1137 aa)
	LOC103462732	Amino acid transporter. (559 aa)
	atp2b1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1219 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	LOC103462684	Neuroplastin b. (379 aa)
	atp2b3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1198 aa)
	adam23	ADAM metallopeptidase domain 23. (883 aa)
	atp2b2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1219 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (421 aa)
	kcnj3	Potassium inwardly-rectifying channel, subfamily J, member 3a. (502 aa)
	LOC103469386	Potassium voltage-gated channel subfamily J member 19a. (515 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	LOC103468990	Amino acid transporter. (675 aa)
	LOC103466506	Synaptotagmin VIIa. (606 aa)
	ENSPREP00000017645	Uncharacterized protein. (191 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	grik5	Glutamate receptor, ionotropic, kainate 5. (957 aa)
	LOC103466432	Si:ch73-330k17.3. (167 aa)
	LOC103466425	Uncharacterized protein. (380 aa)
	nectin1	Nectin cell adhesion molecule 1b. (508 aa)
	LOC103472527	Uncharacterized protein. (1105 aa)
	slc1a2	Amino acid transporter. (537 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	LOC103474519	Zgc:172282. (693 aa)
	LOC103464285	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1162 aa)
	grik4	Glutamate receptor, ionotropic, kainate 4. (967 aa)
	p2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (415 aa)
	LOC103474606	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (136 aa)
	LOC103481312	Potassium voltage-gated channel, subfamily J, member 19b. (517 aa)
	LOC103462425	Synaptotagmin VIIb. (468 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000018776	NCSTN	ENSPREP00000018776	ENSPREP00000001339	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Nicastrin.	0.693
LOC103464285	LOC103474606	ENSPREP00000032339	ENSPREP00000033547	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.423
LOC103465674	LOC103474606	ENSPREP00000003418	ENSPREP00000033547	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.423
LOC103474606	LOC103464285	ENSPREP00000033547	ENSPREP00000032339	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.423
LOC103474606	LOC103465674	ENSPREP00000033547	ENSPREP00000003418	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.423
LOC103474606	atp2b1	ENSPREP00000033547	ENSPREP00000004856	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.423
LOC103474606	atp2b2	ENSPREP00000033547	ENSPREP00000009955	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.423
LOC103474606	atp2b3	ENSPREP00000033547	ENSPREP00000008223	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.423
NCSTN	ENSPREP00000018776	ENSPREP00000001339	ENSPREP00000018776	Nicastrin.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.693
P2RY4	p2rx1	ENSPREP00000014232	ENSPREP00000012171	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.549
P2RY4	p2rx3	ENSPREP00000014232	ENSPREP00000033498	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.430
atp2b1	LOC103474606	ENSPREP00000004856	ENSPREP00000033547	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.423
atp2b2	LOC103474606	ENSPREP00000009955	ENSPREP00000033547	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.423
atp2b3	LOC103474606	ENSPREP00000008223	ENSPREP00000033547	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.423
p2rx1	P2RY4	ENSPREP00000012171	ENSPREP00000014232	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	0.549
p2rx1	p2rx3	ENSPREP00000012171	ENSPREP00000033498	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.776
p2rx3	P2RY4	ENSPREP00000033498	ENSPREP00000014232	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	0.430
p2rx3	p2rx1	ENSPREP00000033498	ENSPREP00000012171	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.776