(56 nodes) Intermembrane lipid transfer network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	plekha8	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8. (565 aa)
	LOC103481463	START domain-containing protein. (272 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (286 aa)
	Pitpnm3	LNS2 domain-containing protein. (249 aa)
	ATG2B	Autophagy related 2B. (2074 aa)
	stard3	StAR-related lipid transfer (START) domain containing 3. (477 aa)
	ENSPREP00000016643	Tocopherol (alpha) transfer protein. (295 aa)
	prelid3a	PRELI domain containing 3A. (207 aa)
	podn	Podocan. (587 aa)
	LOC103473762	Glycolipid transfer protein b. (209 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (945 aa)
	LOC103480954	Si:ch73-269m23.5. (309 aa)
	LOC103475498	Phosphatidylinositol transfer protein, alpha b. (323 aa)
	c2cd2l	C2cd2 like. (705 aa)
	ENSPREP00000022608	GRAM domain-containing protein. (223 aa)
	gltp	Glycolipid transfer protein a. (209 aa)
	LOC103475774	Glycolipid transfer protein domain containing 2. (312 aa)
	stard5	StAR-related lipid transfer (START) domain containing 5. (211 aa)
	cptp	Ceramide-1-phosphate transfer protein. (215 aa)
	LOC103470268	Phosphatidylinositol transfer protein membrane associated 2. (1259 aa)
	ttpal	Tocopherol (alpha) transfer protein-like. (368 aa)
	LOC103466165	Oxysterol-binding protein; Belongs to the OSBP family. (861 aa)
	gramd1c	GRAM domain containing 1c. (657 aa)
	tnfaip8l3	Tumor necrosis factor, alpha-induced protein 8-like 3. (201 aa)
	LOC103473286	Ceramide transporter 1b. (601 aa)
	PITPNM2	Phosphatidylinositol transfer protein membrane associated 2. (1329 aa)
	LOC103473235	Phosphatidylinositol transfer protein, beta. (275 aa)
	pltp	Phospholipid transfer protein. (478 aa)
	LOC103480947	PRELI domain containing 1b. (192 aa)
	atg2a	Autophagy related 2A. (2011 aa)
	LOC103474900	Phosphatidylinositol transfer protein, alpha a. (267 aa)
	LOC103464385	PRELI domain containing 3. (193 aa)
	LOC103462097	Retinaldehyde binding protein 1a. (304 aa)
	LOC103478062	Phosphatidylinositol transfer protein cytoplasmic 1b. (278 aa)
	pitpnb	Phosphatidylinositol transfer protein beta. (265 aa)
	mn1	Meningioma 1b. (1260 aa)
	LOC103474828	Apolipoprotein A-Ib. (263 aa)
	ENSPREP00000010344	Vitellogenin domain-containing protein. (759 aa)
	ENSPREP00000010257	Uncharacterized protein. (434 aa)
	LOC103457447	Apolipoprotein Bb, tandem duplicate 2. (3356 aa)
	rlbp1	Retinaldehyde binding protein 1b. (298 aa)
	LOC103466417	PRELI/MSF1 domain-containing protein. (213 aa)
	ENSPREP00000003269	Uncharacterized protein. (276 aa)
	cetp	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (454 aa)
	CERT1	Ceramide transporter 1. (623 aa)
	abcg8	ATP-binding cassette, sub-family G (WHITE), member 8. (669 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (608 aa)
	prelid1	PRELI domain containing 1a. (210 aa)
	gramd1b	GRAM domain containing 1Bb. (926 aa)
	mttp	Microsomal triglyceride transfer protein. (890 aa)
	scp2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (572 aa)
	apob	Apolipoprotein Ba. (4338 aa)
	Plekha3	PH domain-containing protein. (70 aa)
	ENSPREP00000000316	Uncharacterized protein. (110 aa)
	Pitpnc1	Uncharacterized protein. (117 aa)
	prelid3b	PRELI/MSF1 domain-containing protein. (193 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG2B	atg2a	ENSPREP00000015029	ENSPREP00000022617	Autophagy related 2B.	Autophagy related 2A.	0.909
CERT1	star	ENSPREP00000004969	ENSPREP00000014587	Ceramide transporter 1.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.472
CERT1	stard3	ENSPREP00000004969	ENSPREP00000016275	Ceramide transporter 1.	StAR-related lipid transfer (START) domain containing 3.	0.473
CERT1	stard5	ENSPREP00000004969	ENSPREP00000032653	Ceramide transporter 1.	StAR-related lipid transfer (START) domain containing 5.	0.471
ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	Uncharacterized protein.	Vitellogenin domain-containing protein.	0.739
ENSPREP00000010257	LOC103474828	ENSPREP00000010257	ENSPREP00000010904	Uncharacterized protein.	Apolipoprotein A-Ib.	0.801
ENSPREP00000010257	cetp	ENSPREP00000010257	ENSPREP00000003448	Uncharacterized protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.675
ENSPREP00000010257	mttp	ENSPREP00000010257	ENSPREP00000006570	Uncharacterized protein.	Microsomal triglyceride transfer protein.	0.884
ENSPREP00000010257	pltp	ENSPREP00000010257	ENSPREP00000023197	Uncharacterized protein.	Phospholipid transfer protein.	0.481
ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	Vitellogenin domain-containing protein.	Uncharacterized protein.	0.739
ENSPREP00000010344	LOC103474828	ENSPREP00000010344	ENSPREP00000010904	Vitellogenin domain-containing protein.	Apolipoprotein A-Ib.	0.801
ENSPREP00000010344	cetp	ENSPREP00000010344	ENSPREP00000003448	Vitellogenin domain-containing protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.675
ENSPREP00000010344	mttp	ENSPREP00000010344	ENSPREP00000006570	Vitellogenin domain-containing protein.	Microsomal triglyceride transfer protein.	0.884
ENSPREP00000010344	pltp	ENSPREP00000010344	ENSPREP00000023197	Vitellogenin domain-containing protein.	Phospholipid transfer protein.	0.481
LOC103457447	LOC103474828	ENSPREP00000009874	ENSPREP00000010904	Apolipoprotein Bb, tandem duplicate 2.	Apolipoprotein A-Ib.	0.801
LOC103457447	cetp	ENSPREP00000009874	ENSPREP00000003448	Apolipoprotein Bb, tandem duplicate 2.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.675
LOC103457447	mttp	ENSPREP00000009874	ENSPREP00000006570	Apolipoprotein Bb, tandem duplicate 2.	Microsomal triglyceride transfer protein.	0.884
LOC103457447	pltp	ENSPREP00000009874	ENSPREP00000023197	Apolipoprotein Bb, tandem duplicate 2.	Phospholipid transfer protein.	0.481
LOC103464385	LOC103466417	ENSPREP00000013049	ENSPREP00000008421	PRELI domain containing 3.	PRELI/MSF1 domain-containing protein.	0.668
LOC103464385	LOC103480947	ENSPREP00000013049	ENSPREP00000022651	PRELI domain containing 3.	PRELI domain containing 1b.	0.669