STRINGSTRING
LOC103463058 LOC103463058 LOC103461862 LOC103461862 CYP27A1 CYP27A1 mbtps1 mbtps1 lss lss lcat lcat vldlr vldlr ch25h ch25h LOC103481463 LOC103481463 mvd mvd cetp cetp ldlrap1 ldlrap1 dhcr7 dhcr7 LOC103478550 LOC103478550 gba2 gba2 LOC103477850 LOC103477850 LOC103477849 LOC103477849 LOC103477848 LOC103477848 lrp8 lrp8 LOC103479015 LOC103479015 LOC103462181 LOC103462181 srebf1 srebf1 cubn cubn HSD17B7 HSD17B7 tm7sf2 tm7sf2 apob apob LOC103463731 LOC103463731 Cln6 Cln6 idi1 idi1 LOC103457447 LOC103457447 disp3 disp3 LOC103478110 LOC103478110 ENSPREP00000010257 ENSPREP00000010257 nsdhl nsdhl ENSPREP00000010344 ENSPREP00000010344 LOC103474828 LOC103474828 LOC103466626 LOC103466626 LOC103466612 LOC103466612 LOC103466611 LOC103466611 LOC103466608 LOC103466608 LOC103473017 LOC103473017 LOC103473021 LOC103473021 insig1 insig1 prkaa2 prkaa2 LOC103466560 LOC103466560 star star NPC1L1 NPC1L1 npc2 npc2 LOC103479251 LOC103479251 r3hdm4 r3hdm4 lepr lepr cdcp2 cdcp2 ENSPREP00000017402 ENSPREP00000017402 LOC103473119 LOC103473119 hmgcr hmgcr LOC103472487 LOC103472487 LOC103480471 LOC103480471 LOC103456753 LOC103456753 ENSPREP00000021170 ENSPREP00000021170 hdlbp hdlbp smpd1 smpd1 LOC103465325 LOC103465325 lipe lipe ldlr ldlr scarb1 scarb1 LOC103468275 LOC103468275 ENSPREP00000021963 ENSPREP00000021963 ENSPREP00000022561 ENSPREP00000022561 insig2 insig2 ENSPREP00000022871 ENSPREP00000022871 sc5d sc5d PMVK PMVK sqle sqle Srebf2 Srebf2 ENSPREP00000024568 ENSPREP00000024568 apof apof npc1 npc1 LOC103472050 LOC103472050 arv1 arv1 LOC103469761 LOC103469761 fdps fdps rusc1 rusc1 ENSPREP00000026191 ENSPREP00000026191 Gba Gba LOC103460470 LOC103460470 LOC103457823 LOC103457823 LOC103457824 LOC103457824 LOC103473284 LOC103473284 ENSPREP00000027667 ENSPREP00000027667 idh3b idh3b scap scap ebp ebp fdft1 fdft1 ENSPREP00000029984 ENSPREP00000029984 Lbr Lbr idh1 idh1 lima1 lima1 dhcr24 dhcr24 LOC103462441 LOC103462441 mbtps2 mbtps2 mvk mvk cln8 cln8 idh3g idh3g prkaa1 prkaa1 LOC103476975 LOC103476975 ENSPREP00000031527 ENSPREP00000031527 ENSPREP00000031515 ENSPREP00000031515 angptl3 angptl3 pcsk9 pcsk9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103463058Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor. (861 aa)
LOC103461862Uncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
mbtps1Membrane-bound transcription factor peptidase, site 1. (955 aa)
lssTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (719 aa)
lcatLecithin-cholesterol acyltransferase. (434 aa)
vldlrVery low density lipoprotein receptor. (830 aa)
ch25hCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (249 aa)
LOC103481463START domain-containing protein. (272 aa)
mvdDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (403 aa)
cetpCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (454 aa)
ldlrap1Low density lipoprotein receptor adaptor protein 1b. (287 aa)
dhcr77-dehydrocholesterol reductase. (491 aa)
LOC103478550Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (534 aa)
gba2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (863 aa)
LOC103477850Uncharacterized protein. (255 aa)
LOC103477849Uncharacterized protein. (255 aa)
LOC103477848Apolipoprotein Eb. (265 aa)
lrp8Uncharacterized protein. (937 aa)
LOC103479015Fibrinogen C-terminal domain-containing protein. (471 aa)
LOC103462181Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (455 aa)
srebf1Sterol regulatory element binding transcription factor 1. (1207 aa)
cubnCubilin (intrinsic factor-cobalamin receptor). (3480 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (319 aa)
tm7sf2Transmembrane 7 superfamily member 2. (424 aa)
apobApolipoprotein Ba. (4338 aa)
LOC103463731Hydroxysteroid (17-beta) dehydrogenase 7. (343 aa)
Cln6CLN6 transmembrane ER protein a. (290 aa)
idi1Isopentenyl-diphosphate delta isomerase 1. (304 aa)
LOC103457447Apolipoprotein Bb, tandem duplicate 2. (3356 aa)
disp3Dispatched RND transporter family member 3. (1335 aa)
LOC103478110Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (548 aa)
ENSPREP00000010257Uncharacterized protein. (434 aa)
nsdhlNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (345 aa)
ENSPREP00000010344Vitellogenin domain-containing protein. (759 aa)
LOC103474828Apolipoprotein A-Ib. (263 aa)
LOC103466626Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
LOC103466612Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (276 aa)
LOC103466611Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (276 aa)
LOC103466608Cholesterol 25-hydroxylase like 1, tandem duplicate 2; Belongs to the sterol desaturase family. (277 aa)
LOC103473017Apolipoprotein Ea. (251 aa)
LOC103473021Lipase, hormone-sensitive a. (682 aa)
insig1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (275 aa)
prkaa2Non-specific serine/threonine protein kinase. (557 aa)
LOC103466560Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (517 aa)
starSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (286 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1341 aa)
npc2Niemann-Pick disease, type C2. (158 aa)
LOC103479251Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (513 aa)
r3hdm4R3H domain containing 4. (254 aa)
leprUncharacterized protein. (1121 aa)
cdcp2CUB domain containing protein 2. (390 aa)
ENSPREP00000017402CUB domain-containing protein. (150 aa)
LOC1034731193-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (577 aa)
hmgcr3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
LOC103472487Cytochrome P450, family 51; Belongs to the cytochrome P450 family. (496 aa)
LOC103480471High density lipoprotein binding protein b. (1278 aa)
LOC103456753Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (537 aa)
ENSPREP00000021170Uncharacterized protein. (167 aa)
hdlbpHigh density lipoprotein binding protein a. (1176 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (602 aa)
LOC103465325Cytochrome P450, family 27, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (511 aa)
lipeLipase, hormone-sensitive b. (825 aa)
ldlrLow density lipoprotein receptor a. (811 aa)
scarb1Scavenger receptor class B, member 1; Belongs to the CD36 family. (490 aa)
LOC103468275Low density lipoprotein receptor b. (906 aa)
ENSPREP00000021963LIM zinc-binding domain-containing protein. (129 aa)
ENSPREP00000022561Uncharacterized protein. (283 aa)
insig2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (266 aa)
ENSPREP00000022871PKD domain-containing protein. (262 aa)
sc5dSterol-C5-desaturase; Belongs to the sterol desaturase family. (292 aa)
PMVKPhosphomevalonate kinase. (257 aa)
sqleSqualene epoxidase a. (561 aa)
Srebf2Uncharacterized protein. (209 aa)
ENSPREP00000024568BHLH domain-containing protein. (197 aa)
apofApolipoprotein F. (426 aa)
npc1Niemann-Pick disease, type C1. (1277 aa)
LOC103472050Low density lipoprotein receptor adaptor protein 1a. (310 aa)
arv1ARV1 homolog, fatty acid homeostasis modulator. (240 aa)
LOC103469761Cholesterol 25-hydroxylase like 3. (338 aa)
fdpsUncharacterized protein; Belongs to the FPP/GGPP synthase family. (398 aa)
rusc1RUN and SH3 domain containing 1. (655 aa)
ENSPREP00000026191Glucosylceramidase. (147 aa)
GbaGlucosylceramidase. (291 aa)
LOC103460470Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (496 aa)
LOC103457823Uncharacterized protein. (511 aa)
LOC103457824Uncharacterized protein. (507 aa)
LOC1034732843-hydroxy-3-methylglutaryl coenzyme A reductase. (873 aa)
ENSPREP00000027667Cholesterol 25-hydroxylase like 2; Belongs to the sterol desaturase family. (277 aa)
idh3bIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (386 aa)
scapSREBF chaperone. (1264 aa)
ebpEBP cholestenol delta-isomerase. (249 aa)
fdft1Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
ENSPREP00000029984Tudor domain-containing protein. (152 aa)
LbrUncharacterized protein. (110 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
lima1LIM domain and actin binding 1a. (617 aa)
dhcr2424-dehydrocholesterol reductase. (517 aa)
LOC103462441Cytochrome P450, family 2, subfamily R, polypeptide 1; Belongs to the cytochrome P450 family. (519 aa)
mbtps2Membrane-bound transcription factor peptidase, site 2. (497 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (389 aa)
cln8CLN8 transmembrane ER and ERGIC protein. (288 aa)
idh3gIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (389 aa)
prkaa1Non-specific serine/threonine protein kinase. (637 aa)
LOC103476975ER lipid raft associated 1. (334 aa)
ENSPREP00000031527Uncharacterized protein. (1802 aa)
ENSPREP00000031515LIM zinc-binding domain-containing protein. (211 aa)
angptl3Angiopoietin-like 3. (466 aa)
pcsk9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (671 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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