(128 nodes) Negative regulation of supramolecular fiber organization network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103474479	Uncharacterized protein. (1587 aa)
	tmod1	Tropomodulin 1. (372 aa)
	LOC103465250	Adducin 3 (gamma) a. (685 aa)
	BMERB1	BMERB domain containing 1. (197 aa)
	apc2	APC regulator of WNT signaling pathway 2. (2253 aa)
	LOC103469311	Zgc:77748. (283 aa)
	LOC103469310	Uncharacterized protein. (287 aa)
	myoc	Myocilin. (482 aa)
	LOC103479524	Si:dkeyp-66d1.7. (293 aa)
	LOC103473506	Calmodulin regulated spectrin-associated protein 1a. (1508 aa)
	ENSPREP00000002566	Thymosin beta 5. (36 aa)
	mapre1	Microtubule-associated protein, RP/EB family, member 1b. (258 aa)
	ARHGAP6	Rho GTPase activating protein 6. (507 aa)
	ENSPREP00000003193	PWWP domain-containing protein. (100 aa)
	LOC103471305	Si:ch211-203d1.3. (618 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	Pfdn2	Prefoldin subunit 2. (148 aa)
	rhpn2	Rhophilin, Rho GTPase binding protein 2. (686 aa)
	tbcd	Tubulin folding cofactor D. (1231 aa)
	LOC103478985	Olfactomedin-like domain-containing protein. (500 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	capzb	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (274 aa)
	LMOD3	Leiomodin 3. (539 aa)
	twf2	Twinfilin actin-binding protein 2a. (349 aa)
	LOC103471729	Spectrin beta chain; Belongs to the spectrin family. (2335 aa)
	camsap3	Calmodulin regulated spectrin-associated protein family, member 3. (1466 aa)
	bbs4	Bardet-Biedl syndrome 4. (520 aa)
	camsap1	Calmodulin regulated spectrin-associated protein 1b. (1602 aa)
	ssh2	Slingshot protein phosphatase 2a. (1248 aa)
	LOC103476642	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (725 aa)
	sptan1	Spectrin alpha, non-erythrocytic 1. (2568 aa)
	mkks	McKusick-Kaufman syndrome. (576 aa)
	ENSPREP00000011325	CLa domain-containing protein. (300 aa)
	camsap2	Calmodulin regulated spectrin-associated protein family, member 2a. (1290 aa)
	stmn2	Stathmin; Belongs to the stathmin family. (180 aa)
	LOC103479125	Scinderin like b. (720 aa)
	LOC103480351	Uncharacterized protein. (282 aa)
	rhpn1	Rhophilin, Rho GTPase binding protein 1. (468 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	LOC103460095	Elastin microfibril interfacer 1b. (1203 aa)
	lmod1	Leiomodin 1b (smooth muscle). (655 aa)
	LOC103469336	Supervillin c. (1593 aa)
	vbp1	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (199 aa)
	LOC103474901	Inositol polyphosphate-5-phosphatase Ka. (535 aa)
	LOC103475604	Slingshot protein phosphatase 2b. (1184 aa)
	twf1	Twinfilin actin-binding protein 1a. (350 aa)
	gmfg	Glia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
	plekhh2	Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2. (1417 aa)
	LOC103473692	Inositol polyphosphate-5-phosphatase Ja. (536 aa)
	epcam	Epithelial cell adhesion molecule. (309 aa)
	ENSPREP00000015747	Uncharacterized protein. (47 aa)
	shank1	SH3 and multiple ankyrin repeat domains 1. (834 aa)
	Shank1	SAM domain-containing protein. (1628 aa)
	LOC103458433	Non-specific serine/threonine protein kinase. (507 aa)
	ENSPREP00000017225	Uncharacterized protein. (106 aa)
	LOC103476183	PH domain-containing protein. (1567 aa)
	kank3	KN motif and ankyrin repeat domains 3. (988 aa)
	lmod2	Leiomodin 2 (cardiac) b. (544 aa)
	LOC103473743	Slingshot protein phosphatase 1b. (631 aa)
	ENSPREP00000018081	PH_9 domain-containing protein. (637 aa)
	ENSPREP00000018112	Uncharacterized protein. (369 aa)
	ENSPREP00000018131	Uncharacterized protein. (258 aa)
	ENSPREP00000018142	Uncharacterized protein. (49 aa)
	LOC103476775	Adducin 3 (gamma) b. (678 aa)
	LOC103480677	FERM domain-containing protein. (656 aa)
	LOC103474715	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (41 aa)
	ENSPREP00000019223	Uncharacterized protein. (109 aa)
	LOC103458402	Spectrin beta chain; Belongs to the spectrin family. (2088 aa)
	capg	Capping protein (actin filament), gelsolin-like b. (344 aa)
	plekhh1	Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1. (1425 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	LOC103463987	Scinderin like a. (704 aa)
	LOC103479821	Clusterin; Belongs to the clusterin family. (464 aa)
	avil	Advillin. (816 aa)
	ENSPREP00000021963	LIM zinc-binding domain-containing protein. (129 aa)
	LOC103466031	SH3 and multiple ankyrin repeat domains 3a. (1984 aa)
	ENSPREP00000022293	BMERB domain-containing protein. (131 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	LOC103475499	Inositol polyphosphate-5-phosphatase Kb. (522 aa)
	clu	Clusterin; Belongs to the clusterin family. (369 aa)
	LOC103463007	SH3 and multiple ankyrin repeat domains 2a. (1709 aa)
	LOC103479365	Calmodulin regulated spectrin-associated protein family, member 2b. (1338 aa)
	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (894 aa)
	kank1	KN motif and ankyrin repeat domains 1. (1292 aa)
	LOC103460379	Gelsolin b. (738 aa)
	pfdn5	Prefoldin 5. (155 aa)
	Map6d1	MAP6 domain containing 1. (334 aa)
	ENSPREP00000025132	Zgc:171844. (190 aa)
	add1	Adducin 1 (alpha). (774 aa)
	apc	APC regulator of WNT signaling pathway. (2002 aa)
	pick1	Protein interacting with prkca 1. (409 aa)
	LOC103481054	Uncharacterized protein. (2065 aa)
	LOC103475461	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (164 aa)
	add2	Adducin 2 (beta). (669 aa)
	gmfb	Glia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	tmod3	Tropomodulin 2. (415 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (195 aa)
	atxn7	Ataxin 7. (939 aa)
	svil	Supervillin a. (2345 aa)
	capza1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	sptbn4	Spectrin, beta, non-erythrocytic 4b. (1946 aa)
	LOC103481123	Uncharacterized protein. (280 aa)
	LOC103481154	MARVEL domain-containing protein. (288 aa)
	LOC103457775	Elastin microfibril interfacer 1a. (1023 aa)
	tmod4	Tropomodulin 4 (muscle). (340 aa)
	LOC103479487	HP domain-containing protein. (2611 aa)
	flii	FLII actin remodeling protein. (866 aa)
	LOC103465460	Ataxin 7-like 2a. (794 aa)
	lima1	LIM domain and actin binding 1a. (617 aa)
	LOC103473351	KN motif and ankyrin repeat domains 1b. (1246 aa)
	LOC103478616	Stathmin 2a. (225 aa)
	pak2	Non-specific serine/threonine protein kinase. (525 aa)
	vill	Villin-like. (845 aa)
	WDR63	WD repeat domain 63. (767 aa)
	ENSPREP00000031515	LIM zinc-binding domain-containing protein. (211 aa)
	ENSPREP00000031527	Uncharacterized protein. (1802 aa)
	LOC103470276	Inositol polyphosphate-5-phosphatase Jb. (602 aa)
	spef1	Zgc:66426. (171 aa)
	LOC103473971	Gelsolin a. (479 aa)
	ssh1	Slingshot protein phosphatase 1a. (1019 aa)
	pfdn6	Prefoldin subunit 6. (126 aa)
	hspg2	Heparan sulfate proteoglycan 2. (3385 aa)
	LOC103475799	F11 receptor, tandem duplicate 1. (308 aa)
	LOC103481333	Supervillin d. (1202 aa)
	LOC103475822	Spectrin beta chain; Belongs to the spectrin family. (2375 aa)
	cgnl1	Cingulin-like 1. (1279 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF2	cgnl1	ENSPREP00000023681	ENSPREP00000034334	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Cingulin-like 1.	0.549
CAPZA2	WDR63	ENSPREP00000003834	ENSPREP00000031457	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	WD repeat domain 63.	0.486
CAPZA2	capza1	ENSPREP00000003834	ENSPREP00000027979	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.901
CAPZA2	capzb	ENSPREP00000003834	ENSPREP00000006745	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.988
CAPZA2	twf1	ENSPREP00000003834	ENSPREP00000014652	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 1a.	0.613
CAPZA2	twf2	ENSPREP00000003834	ENSPREP00000007091	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 2a.	0.613
ENSPREP00000002566	LOC103474715	ENSPREP00000002566	ENSPREP00000018527	Thymosin beta 5.	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.	0.901
ENSPREP00000018081	ENSPREP00000018112	ENSPREP00000018081	ENSPREP00000018112	PH_9 domain-containing protein.	Uncharacterized protein.	0.951
ENSPREP00000018081	ENSPREP00000018131	ENSPREP00000018081	ENSPREP00000018131	PH_9 domain-containing protein.	Uncharacterized protein.	0.900
ENSPREP00000018081	sptan1	ENSPREP00000018081	ENSPREP00000010216	PH_9 domain-containing protein.	Spectrin alpha, non-erythrocytic 1.	0.862
ENSPREP00000018112	ENSPREP00000018081	ENSPREP00000018112	ENSPREP00000018081	Uncharacterized protein.	PH_9 domain-containing protein.	0.951
ENSPREP00000018112	ENSPREP00000018131	ENSPREP00000018112	ENSPREP00000018131	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSPREP00000018112	sptan1	ENSPREP00000018112	ENSPREP00000010216	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.862
ENSPREP00000018131	ENSPREP00000018081	ENSPREP00000018131	ENSPREP00000018081	Uncharacterized protein.	PH_9 domain-containing protein.	0.900
ENSPREP00000018131	ENSPREP00000018112	ENSPREP00000018131	ENSPREP00000018112	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSPREP00000018131	LOC103476183	ENSPREP00000018131	ENSPREP00000017361	Uncharacterized protein.	PH domain-containing protein.	0.876
ENSPREP00000018131	sptan1	ENSPREP00000018131	ENSPREP00000010216	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.890
ENSPREP00000018142	sptan1	ENSPREP00000018142	ENSPREP00000010216	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.835
ENSPREP00000019223	sptan1	ENSPREP00000019223	ENSPREP00000010216	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.862
LOC103458402	LOC103475822	ENSPREP00000019316	ENSPREP00000033969	Spectrin beta chain; Belongs to the spectrin family.	Spectrin beta chain; Belongs to the spectrin family.	0.401