(72 nodes) Regulation of response to wounding network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	st3gal4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (339 aa)
	LOC103467806	Uncharacterized protein. (225 aa)
	ptn	Pleiotrophin. (161 aa)
	scarf1	Scavenger receptor class F, member 1. (894 aa)
	pros1	Protein S. (675 aa)
	CD9	Tetraspanin. (210 aa)
	cask	Uncharacterized protein; Belongs to the MAGUK family. (884 aa)
	LOC103461875	Tissue factor pathway inhibitor. (263 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	ENSPREP00000029506	WAP four-disulfide core domain 1. (185 aa)
	LOC103457758	Uncharacterized protein. (635 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	LOC103473499	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	ENSPREP00000026566	Kringle domain-containing protein. (105 aa)
	ENSPREP00000026553	Kringle domain-containing protein. (99 aa)
	ENSPREP00000026545	Uncharacterized protein. (90 aa)
	plg	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (715 aa)
	fermt1	Fermitin family member 1. (666 aa)
	Vegfb	Vascular endothelial growth factor Bb; Belongs to the PDGF/VEGF growth factor family. (94 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	LOC103460304	LRRCT domain-containing protein. (666 aa)
	cd34	Uncharacterized protein. (211 aa)
	LOC103479267	Uncharacterized protein. (1084 aa)
	LOC103474715	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (41 aa)
	LOC103459415	Anoctamin. (918 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	epha4	Eph receptor A4, like. (979 aa)
	ajap1	Adherens junctions associated protein 1. (397 aa)
	LOC103474919	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (762 aa)
	ENSPREP00000015283	Reticulon 4 receptor-like 1b. (451 aa)
	LOC103481658	LRRNT domain-containing protein. (450 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (477 aa)
	LOC103475595	Reticulon 4 receptor-like 1a. (454 aa)
	rreb1	Ras responsive element binding protein 1a. (1526 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	LOC103475843	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family. (950 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	LOC103467244	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family. (597 aa)
	enpp4	Ectonucleotide pyrophosphatase/phosphodiesterase 4. (455 aa)
	fgb	Fibrinogen beta chain. (492 aa)
	LOC103463442	Thromboxane A2 receptor. (379 aa)
	LOC103463443	Thromboxane A2 receptor. (378 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (228 aa)
	ENSPREP00000010695	Elastin microfibril interfacer 2b. (910 aa)
	LOC103479092	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	LOC103468140	LRRNT domain-containing protein. (359 aa)
	LOC103466662	Tetraspanin. (237 aa)
	LOC103471128	Heparin-binding EGF-like growth factor a. (236 aa)
	Rtn4r	Reticulon 4 receptor. (452 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (617 aa)
	LOC103469263	Parvalbumin 8; Belongs to the parvalbumin family. (109 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	xbp1	X-box binding protein 1. (385 aa)
	kremen1	Kringle containing transmembrane protein 1. (481 aa)
	il10	Interleukin 10. (229 aa)
	LOC103460587	Uncharacterized protein. (448 aa)
	ENSPREP00000005246	Protein kinase domain-containing protein. (250 aa)
	LOC103475300	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
	LOC103480133	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	MYOZ1	Myozenin 1. (316 aa)
	Cav1	Uncharacterized protein. (84 aa)
	LOC103459868	SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
	LOC103477151	Uncharacterized protein. (158 aa)
	serpinc1	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (455 aa)
	APOH-2	Apolipoprotein H. (363 aa)
	APOH	Uncharacterized protein. (348 aa)
	LOC103476211	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (229 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	c1qtnf6	C1q and TNF related 6b. (260 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOH	ENSPREP00000026545	ENSPREP00000000302	ENSPREP00000026545	Uncharacterized protein.	Uncharacterized protein.	0.557
APOH	ENSPREP00000026553	ENSPREP00000000302	ENSPREP00000026553	Uncharacterized protein.	Kringle domain-containing protein.	0.557
APOH	ENSPREP00000026566	ENSPREP00000000302	ENSPREP00000026566	Uncharacterized protein.	Kringle domain-containing protein.	0.557
APOH	LOC103459868	ENSPREP00000000302	ENSPREP00000003297	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.512
APOH	LOC103460587	ENSPREP00000000302	ENSPREP00000005276	Uncharacterized protein.	Uncharacterized protein.	0.553
APOH	f2	ENSPREP00000000302	ENSPREP00000016717	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.783
APOH	fgb	ENSPREP00000000302	ENSPREP00000011828	Uncharacterized protein.	Fibrinogen beta chain.	0.568
APOH	plg	ENSPREP00000000302	ENSPREP00000026525	Uncharacterized protein.	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.557
APOH	serpinc1	ENSPREP00000000302	ENSPREP00000001582	Uncharacterized protein.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.726
APOH	serpinf2	ENSPREP00000000302	ENSPREP00000015036	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.512
APOH-2	ENSPREP00000026545	ENSPREP00000000303	ENSPREP00000026545	Apolipoprotein H.	Uncharacterized protein.	0.557
APOH-2	ENSPREP00000026553	ENSPREP00000000303	ENSPREP00000026553	Apolipoprotein H.	Kringle domain-containing protein.	0.557
APOH-2	ENSPREP00000026566	ENSPREP00000000303	ENSPREP00000026566	Apolipoprotein H.	Kringle domain-containing protein.	0.557
APOH-2	LOC103459868	ENSPREP00000000303	ENSPREP00000003297	Apolipoprotein H.	SERPIN domain-containing protein; Belongs to the serpin family.	0.512
APOH-2	LOC103460587	ENSPREP00000000303	ENSPREP00000005276	Apolipoprotein H.	Uncharacterized protein.	0.553
APOH-2	f2	ENSPREP00000000303	ENSPREP00000016717	Apolipoprotein H.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.783
APOH-2	fgb	ENSPREP00000000303	ENSPREP00000011828	Apolipoprotein H.	Fibrinogen beta chain.	0.568
APOH-2	plg	ENSPREP00000000303	ENSPREP00000026525	Apolipoprotein H.	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.557
APOH-2	serpinc1	ENSPREP00000000303	ENSPREP00000001582	Apolipoprotein H.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.726
APOH-2	serpinf2	ENSPREP00000000303	ENSPREP00000015036	Apolipoprotein H.	SERPIN domain-containing protein; Belongs to the serpin family.	0.512