(120 nodes) Meiotic cell cycle process network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000018817	DDE_3 domain-containing protein. (102 aa)
	brca2	BRCA2 DNA repair associated. (3038 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1355 aa)
	spata22	Spermatogenesis associated 22. (382 aa)
	Mos	V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (376 aa)
	ccnb1ip1	Cyclin B1 interacting protein 1. (239 aa)
	msh4	MutS homolog 4. (848 aa)
	ENSPREP00000016414	DDE_3 domain-containing protein. (122 aa)
	ENSPREP00000016855	Uncharacterized protein. (340 aa)
	ENSPREP00000016868	HTH_Tnp_Tc3_2 domain-containing protein. (198 aa)
	ndc1	NDC1 transmembrane nucleoporin. (669 aa)
	mei4	Meiotic double-stranded break formation protein 4. (376 aa)
	smc2	Structural maintenance of chromosomes protein. (1200 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1463 aa)
	mnd1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (205 aa)
	Sirt7	Uncharacterized protein. (134 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1. (1791 aa)
	LOC103464578	Synaptonemal complex central element protein 2. (186 aa)
	rad51	RAD51 recombinase. (219 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (726 aa)
	ccdc36	Uncharacterized protein. (429 aa)
	ENSPREP00000002399	DDE_3 domain-containing protein. (140 aa)
	Bcl2l11	Uncharacterized protein. (202 aa)
	smc4	Structural maintenance of chromosomes 4. (1155 aa)
	fbxo5	F-box protein 5. (376 aa)
	cenpx	Centromere protein X. (74 aa)
	asz1	Ankyrin repeat, SAM and basic leucine zipper domain containing 1. (472 aa)
	ENSPREP00000003940	DDE_3 domain-containing protein. (101 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	spire2	Spire-type actin nucleation factor 2. (773 aa)
	bag6	BCL2 associated athanogene 6. (1194 aa)
	ENSPREP00000005518	Uncharacterized protein. (294 aa)
	tdrkh	Tudor and KH domain containing. (587 aa)
	ENSPREP00000006389	DDE_3 domain-containing protein. (195 aa)
	atrx	ATRX chromatin remodeler. (2188 aa)
	ENSPREP00000006667	Zebrafish testis-expressed 38. (320 aa)
	tdrd12	Tudor domain containing 12. (1141 aa)
	LOC103464484	Forkhead box J3. (605 aa)
	incenp	Uncharacterized protein. (755 aa)
	ENSPREP00000017650	Uncharacterized protein. (134 aa)
	pttg1	Uncharacterized protein. (177 aa)
	ENSPREP00000023462	Uncharacterized protein. (132 aa)
	ENSPREP00000023712	Uncharacterized protein. (340 aa)
	espl1	Extra spindle pole bodies like 1, separase. (2165 aa)
	LOC103478201	Spire-type actin nucleation factor 1b. (804 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	Mei1	Uncharacterized protein. (321 aa)
	psmd13	Proteasome 26S subunit, non-ATPase 13. (258 aa)
	dmc1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (343 aa)
	LOC103482091	Essential meiotic structure-specific endonuclease 1. (232 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	rec8	REC8 meiotic recombination protein b. (566 aa)
	ENSPREP00000026124	Uncharacterized protein. (290 aa)
	msh5	MutS homolog 5. (816 aa)
	hsf2bp	Heat shock transcription factor 2 binding protein. (339 aa)
	terf1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (367 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (394 aa)
	EME2	ERCC4 domain-containing protein. (370 aa)
	ENSPREP00000028030	Uncharacterized protein. (340 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (671 aa)
	sycp2	Uncharacterized protein. (1567 aa)
	ENSPREP00000028777	Non-SMC condensin II complex, subunit H2. (419 aa)
	hormad1	HORMA domain containing 1. (372 aa)
	fancm	Uncharacterized protein. (1901 aa)
	LOC103481969	Baculoviral IAP repeat containing 5a. (157 aa)
	LOC103481653	Uncharacterized protein. (877 aa)
	meioc	Uncharacterized protein. (822 aa)
	mlh3	MutL homolog 3 (E. coli). (1117 aa)
	fancd2	FA complementation group D2. (1432 aa)
	tex11	Testis expressed 11. (770 aa)
	LOC103469983	EGF-like domain-containing protein. (154 aa)
	LOC103460156	SYCP2_SLD domain-containing protein. (696 aa)
	tubg1	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
	ENSPREP00000013378	HTH_Tnp_Tc3_2 domain-containing protein. (309 aa)
	edn1	Endothelin 1. (207 aa)
	spo11	SPO11 initiator of meiotic double stranded breaks. (379 aa)
	hfm1	Helicase for meiosis 1. (1062 aa)
	ankle1	Zgc:85936. (834 aa)
	LOC103472367	Spire-type actin nucleation factor 1a. (775 aa)
	shoc1	Uncharacterized protein. (1440 aa)
	sgo1	Shugoshin_C domain-containing protein. (585 aa)
	Syce3	Uncharacterized protein. (81 aa)
	majin	Membrane anchored junction protein. (217 aa)
	nuf2	UF2 component of NDC80 kinetochore complex. (449 aa)
	ncapd3	Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1311 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1577 aa)
	fanca	Fanconi_A_N domain-containing protein. (965 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (414 aa)
	ENSPREP00000031619	Uncharacterized protein. (89 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (427 aa)
	ENSPREP00000032512	Uncharacterized protein. (112 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (909 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)
	ENSPREP00000033716	Fork-head domain-containing protein. (175 aa)
	ENSPREP00000033734	Uncharacterized protein. (136 aa)
	terb2	Telomere repeat binding bouquet formation protein 2. (222 aa)
	ncapd2	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1369 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (245 aa)
	ENSPREP00000014926	DDE_3 domain-containing protein. (183 aa)
	ENSPREP00000014648	Uncharacterized protein. (340 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (616 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	ncaph	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (696 aa)
	ENSPREP00000022562	Tudor domain containing 9. (993 aa)
	ttk	Ttk protein kinase. (996 aa)
	ENSPREP00000022390	Uncharacterized protein. (286 aa)
	terb1	Telomere repeat binding bouquet formation protein 1. (804 aa)
	ENSPREP00000021048	BUB1 N-terminal domain-containing protein. (264 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
	brdt	Bromodomain, testis-specific. (980 aa)
	C1orf146	Chromosome 1 open reading frame 146. (172 aa)
	rad51d	RAD51 paralog D. (350 aa)
	LOC103471340	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	ENSPREP00000033904	Uncharacterized protein. (340 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1604 aa)
	ENSPREP00000019814	Uncharacterized protein. (141 aa)
	rad51c	RAD51 paralog C. (377 aa)
	ENSPREP00000019136	Uncharacterized protein. (332 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bub1	ENSPREP00000021048	ENSPREP00000021030	ENSPREP00000021048	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 N-terminal domain-containing protein.	0.847
Bub1	KIF18A	ENSPREP00000021030	ENSPREP00000033468	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.814
Bub1	LOC103481969	ENSPREP00000021030	ENSPREP00000029516	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Baculoviral IAP repeat containing 5a.	0.877
Bub1	brca2	ENSPREP00000021030	ENSPREP00000018297	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BRCA2 DNA repair associated.	0.416
Bub1	bub1b	ENSPREP00000021030	ENSPREP00000032059	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.986
Bub1	dmc1	ENSPREP00000021030	ENSPREP00000025114	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.623
Bub1	espl1	ENSPREP00000021030	ENSPREP00000024176	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Extra spindle pole bodies like 1, separase.	0.894
Bub1	fancd2	ENSPREP00000021030	ENSPREP00000014095	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	FA complementation group D2.	0.401
Bub1	fbxo5	ENSPREP00000021030	ENSPREP00000003225	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	F-box protein 5.	0.425
Bub1	hus1	ENSPREP00000021030	ENSPREP00000015273	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Checkpoint protein; Belongs to the HUS1 family.	0.436
Bub1	incenp	ENSPREP00000021030	ENSPREP00000017581	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.903
Bub1	mnd1	ENSPREP00000021030	ENSPREP00000000503	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family.	0.578
Bub1	ncapd2	ENSPREP00000021030	ENSPREP00000016021	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	0.520
Bub1	ncaph	ENSPREP00000021030	ENSPREP00000022711	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.	0.768
Bub1	nuf2	ENSPREP00000021030	ENSPREP00000030246	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	UF2 component of NDC80 kinetochore complex.	0.953
Bub1	pttg1	ENSPREP00000021030	ENSPREP00000018157	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.741
Bub1	rad51	ENSPREP00000021030	ENSPREP00000001621	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RAD51 recombinase.	0.704
Bub1	rad51c	ENSPREP00000021030	ENSPREP00000019301	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RAD51 paralog C.	0.623
Bub1	rad51d	ENSPREP00000021030	ENSPREP00000020832	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RAD51 paralog D.	0.479
Bub1	sgo1	ENSPREP00000021030	ENSPREP00000009459	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Shugoshin_C domain-containing protein.	0.944