(118 nodes) Positive regulation of secretion by cell network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	unc13d	Unc-13 homolog D (C. elegans). (1110 aa)
	LOC103476935	ZP domain-containing protein. (392 aa)
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (123 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	LOC103461636	Sorting nexin 4. (455 aa)
	ENSPREP00000016383	ADP-ribosylation factor 6b. (113 aa)
	LOC103466506	Synaptotagmin VIIa. (606 aa)
	LOC103460214	Uncharacterized protein. (269 aa)
	ENSPREP00000018877	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (121 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (782 aa)
	LOC103470220	Myomesin 2a. (1386 aa)
	lamp1	Lysosomal associated membrane protein 1a. (409 aa)
	LOC103464268	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (211 aa)
	ptges	Prostaglandin E synthase. (150 aa)
	LOC103465552	GATA binding protein 1a. (426 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	c2cd2l	C2cd2 like. (705 aa)
	LOC103462425	Synaptotagmin VIIb. (468 aa)
	mcu	Mitochondrial calcium uniporter. (376 aa)
	exoc1	Exocyst complex component 1. (927 aa)
	ptpn23	Protein tyrosine phosphatase, non-receptor type 23, a. (1885 aa)
	crh	Corticotropin releasing hormone b. (176 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	LOC103466144	Zgc:123278. (130 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	sri	Uncharacterized protein. (187 aa)
	ucn	Urotensin 1. (147 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	tmf1	TATA element modulatory factor 1. (1150 aa)
	Gper1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (321 aa)
	LOC103459747	PX domain-containing protein. (433 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	rfx6	Regulatory factor X, 6. (831 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	LOC103465401	GLUCAGON domain-containing protein. (195 aa)
	ENSPREP00000025511	Uncharacterized protein. (81 aa)
	LOC103469641	Golgi phosphoprotein 3. (245 aa)
	SPHK1	Sphingosine kinase 1. (564 aa)
	capn10	Calpain 10; Belongs to the peptidase C2 family. (670 aa)
	ENSPREP00000023453	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (755 aa)
	LOC103466429	Secretory carrier-associated membrane protein. (239 aa)
	trh	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (269 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (567 aa)
	ENSPREP00000022805	V-SNARE coiled-coil homology domain-containing protein. (116 aa)
	ENSPREP00000022754	Vesicle-associated membrane protein 8 (endobrevin). (118 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	ENSPREP00000022524	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (174 aa)
	tm7sf3	Transmembrane 7 superfamily member 3. (550 aa)
	LOC103466036	ZP domain-containing protein. (423 aa)
	gab2	GRB2-associated binding protein 2. (676 aa)
	LOC103480960	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1b. (337 aa)
	LOC103471983	Endothelin 2. (172 aa)
	LOC103462853	Uncharacterized protein. (1438 aa)
	stam	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (512 aa)
	LOC103479813	Si:ch211-106h4.9. (986 aa)
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	LOC103479798	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	LOC103479803	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	LOC103474249	Grancalcin. (230 aa)
	LOC103462870	Synaptotagmin IXa. (559 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (821 aa)
	rab27a	RAB27A, member RAS oncogene family. (163 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
	ENSPREP00000001350	Uncharacterized protein. (93 aa)
	hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate. (765 aa)
	c1qtnf6	C1q and TNF related 6b. (260 aa)
	LOC103462158	Secretory carrier-associated membrane protein. (229 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (878 aa)
	ier3ip1	Immediate early response 3 interacting protein 1. (86 aa)
	SPHK1-2	Sphingosine kinase 1. (367 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	LOC103465473	Ca2+-dependent activator protein for secretion a. (1254 aa)
	ENSPREP00000030224	PID domain-containing protein. (124 aa)
	LOC103466244	Synaptotagmin IXb. (529 aa)
	ENSPREP00000002127	RabBD domain-containing protein. (192 aa)
	LOC103460504	Galanin receptor 1b; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	vip	Vasoactive intestinal peptide. (184 aa)
	MCUB	Mitochondrial calcium uniporter dominant negative beta subunit. (336 aa)
	aimp1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1a. (317 aa)
	golph3	Si:dkey-27b3.2. (294 aa)
	cadps	Ca2+-dependent activator protein for secretion b. (1329 aa)
	vps4a	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (436 aa)
	Rgcc	Regulator of cell cycle. (134 aa)
	LOC103463808	Uncharacterized protein; Belongs to the AAA ATPase family. (411 aa)
	LOC103465768	Par-6 family cell polarity regulator alpha. (420 aa)
	LOC103470500	NK3 homeobox 1. (196 aa)
	LOC103461426	Uncharacterized protein. (115 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	myom1	Myomesin 1b. (1497 aa)
	sphk2	Sphingosine kinase 2. (820 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1a. (202 aa)
	CADPS2	Calcium dependent secretion activator 2. (1241 aa)
	ENSPREP00000011238	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (195 aa)
	LOC103469909	Uncharacterized protein. (227 aa)
	ppid	Peptidylprolyl isomerase D. (373 aa)
	baiap3	BAI1-associated protein 3. (1176 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	fgb	Fibrinogen beta chain. (492 aa)
	wls	Wnt ligand secretion mediator. (448 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (210 aa)
	ENSPREP00000012104	Phospholipase A(2). (160 aa)
	dtnbp1	Dystrobrevin binding protein 1b. (229 aa)
	aacs	Acetoacetyl-CoA synthetase. (676 aa)
	edn1	Endothelin 1. (207 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (260 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	LOC103467077	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1132 aa)
	kiaa0100	Si:ch211-259g3.4. (1564 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCYAP1	LOC103461426	ENSPREP00000011176	ENSPREP00000009561	Adenylate cyclase activating polypeptide 1a.	Uncharacterized protein.	0.902
ADCYAP1	crh	ENSPREP00000011176	ENSPREP00000029457	Adenylate cyclase activating polypeptide 1a.	Corticotropin releasing hormone b.	0.411
ENSPREP00000001350	ENSPREP00000002127	ENSPREP00000001350	ENSPREP00000002127	Uncharacterized protein.	RabBD domain-containing protein.	0.471
ENSPREP00000001350	LOC103479813	ENSPREP00000001350	ENSPREP00000020508	Uncharacterized protein.	Si:ch211-106h4.9.	0.471
ENSPREP00000001350	capn10	ENSPREP00000001350	ENSPREP00000023794	Uncharacterized protein.	Calpain 10; Belongs to the peptidase C2 family.	0.408
ENSPREP00000001350	dtnbp1	ENSPREP00000001350	ENSPREP00000012354	Uncharacterized protein.	Dystrobrevin binding protein 1b.	0.467
ENSPREP00000002127	ENSPREP00000001350	ENSPREP00000002127	ENSPREP00000001350	RabBD domain-containing protein.	Uncharacterized protein.	0.471
ENSPREP00000002127	LOC103469909	ENSPREP00000002127	ENSPREP00000011273	RabBD domain-containing protein.	Uncharacterized protein.	0.471
ENSPREP00000002127	RAB27B	ENSPREP00000002127	ENSPREP00000029842	RabBD domain-containing protein.	RAB27B, member RAS oncogene family.	0.471
ENSPREP00000002127	rab27a	ENSPREP00000002127	ENSPREP00000001371	RabBD domain-containing protein.	RAB27A, member RAS oncogene family.	0.471
ENSPREP00000016383	ptpn23	ENSPREP00000016383	ENSPREP00000029531	ADP-ribosylation factor 6b.	Protein tyrosine phosphatase, non-receptor type 23, a.	0.453
ENSPREP00000022524	ptpn23	ENSPREP00000022524	ENSPREP00000029531	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Protein tyrosine phosphatase, non-receptor type 23, a.	0.453
ENSPREP00000022754	LOC103462870	ENSPREP00000022754	ENSPREP00000019678	Vesicle-associated membrane protein 8 (endobrevin).	Synaptotagmin IXa.	0.442
ENSPREP00000022754	LOC103466244	ENSPREP00000022754	ENSPREP00000002121	Vesicle-associated membrane protein 8 (endobrevin).	Synaptotagmin IXb.	0.442
ENSPREP00000022754	hgs	ENSPREP00000022754	ENSPREP00000006028	Vesicle-associated membrane protein 8 (endobrevin).	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.514
ENSPREP00000022754	stam	ENSPREP00000022754	ENSPREP00000020824	Vesicle-associated membrane protein 8 (endobrevin).	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1.	0.506
ENSPREP00000022805	LOC103462870	ENSPREP00000022805	ENSPREP00000019678	V-SNARE coiled-coil homology domain-containing protein.	Synaptotagmin IXa.	0.442
ENSPREP00000022805	LOC103466244	ENSPREP00000022805	ENSPREP00000002121	V-SNARE coiled-coil homology domain-containing protein.	Synaptotagmin IXb.	0.442
ENSPREP00000022805	hgs	ENSPREP00000022805	ENSPREP00000006028	V-SNARE coiled-coil homology domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.514
ENSPREP00000022805	stam	ENSPREP00000022805	ENSPREP00000020824	V-SNARE coiled-coil homology domain-containing protein.	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1.	0.506