(49 nodes) Regulation of reactive oxygen species metabolic process network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	brca1	Uncharacterized protein. (1344 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	coq7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (221 aa)
	mpv17l	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (210 aa)
	LOC103464595	Translocator protein. (147 aa)
	LOC103464594	Translocator protein. (161 aa)
	LOC103462573	Cytochrome b-245, alpha polypeptide. (126 aa)
	LOC103477101	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (536 aa)
	vdac1	Voltage-dependent anion channel 1. (258 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	abcb7	ATP-binding cassette, sub-family B (MDR/TAP), member 7. (664 aa)
	ENSPREP00000006454	Uncharacterized protein. (116 aa)
	LOC103464509	Tumor suppressor 2, mitochondrial calcium regulator. (109 aa)
	LOC103481546	GTP cyclohydrolase 2. (236 aa)
	apopt1	Cytochrome c oxidase assembly factor 8. (195 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (617 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (623 aa)
	park7	Parkinson protein 7. (189 aa)
	LOC103470486	Beta-carotene 15, 15-dioxygenase 2, like. (579 aa)
	LOC103479635	Death domain-containing protein. (536 aa)
	acod1	Aconitate decarboxylase 1. (531 aa)
	romo1	Reactive oxygen species modulator 1. (79 aa)
	LOC103478098	Si:ch211-120k19.1; Belongs to the peroxisomal membrane protein PXMP2/4 family. (187 aa)
	ENSPREP00000010947	Uncharacterized protein. (306 aa)
	abcd2	ATP-binding cassette, sub-family D (ALD), member 2. (790 aa)
	LOC103465102	Tumor suppressor 2, mitochondrial calcium regulator b. (111 aa)
	ENSPREP00000030584	Cytochrome P450, family 1, subfamily C, polypeptide 2. (479 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	gch1	GTP cyclohydrolase 1. (255 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	TGFBR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
	pid1	Phosphotyrosine interaction domain containing 1. (225 aa)
	bves	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (824 aa)
	pikfyve	Phosphoinositide kinase, FYVE finger containing. (2073 aa)
	duoxa1	Dual oxidase 2. (337 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	LOC103475801	Beta-carotene oxygenase 2a. (549 aa)
	LOC103466013	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	aatf	Apoptosis antagonizing transcription factor. (548 aa)
	LOC103469059	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (184 aa)
	dhfr	Dihydrofolate reductase. (187 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
	ENSPREP00000014507	UBA_6 domain-containing protein. (200 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	foxm1	Forkhead box M1. (659 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000020277	LOC103466013	ENSPREP00000020277	ENSPREP00000021307	RBR-type E3 ubiquitin transferase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.704
ENSPREP00000020277	LOC103479635	ENSPREP00000020277	ENSPREP00000009477	RBR-type E3 ubiquitin transferase.	Death domain-containing protein.	0.473
ENSPREP00000020277	atg5	ENSPREP00000020277	ENSPREP00000028618	RBR-type E3 ubiquitin transferase.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.567
ENSPREP00000020277	park7	ENSPREP00000020277	ENSPREP00000008597	RBR-type E3 ubiquitin transferase.	Parkinson protein 7.	0.929
ENSPREP00000020277	pink1	ENSPREP00000020277	ENSPREP00000032869	RBR-type E3 ubiquitin transferase.	PTEN induced kinase 1.	0.996
ENSPREP00000020277	vdac1	ENSPREP00000020277	ENSPREP00000004744	RBR-type E3 ubiquitin transferase.	Voltage-dependent anion channel 1.	0.870
LOC103464594	vdac1	ENSPREP00000002881	ENSPREP00000004744	Translocator protein.	Voltage-dependent anion channel 1.	0.567
LOC103464595	vdac1	ENSPREP00000002855	ENSPREP00000004744	Translocator protein.	Voltage-dependent anion channel 1.	0.567
LOC103466013	ENSPREP00000020277	ENSPREP00000021307	ENSPREP00000020277	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RBR-type E3 ubiquitin transferase.	0.704
LOC103466013	LOC103479635	ENSPREP00000021307	ENSPREP00000009477	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Death domain-containing protein.	0.997
LOC103469059	abcd2	ENSPREP00000019598	ENSPREP00000011112	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	ATP-binding cassette, sub-family D (ALD), member 2.	0.406
LOC103469059	mpv17l	ENSPREP00000019598	ENSPREP00000000679	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.901
LOC103475119	TGFBR2	ENSPREP00000027136	ENSPREP00000026860	Transforming growth factor beta; Belongs to the TGF-beta family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
LOC103475119	tgfbr2	ENSPREP00000027136	ENSPREP00000016340	Transforming growth factor beta; Belongs to the TGF-beta family.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.997
LOC103478098	abcd2	ENSPREP00000010532	ENSPREP00000011112	Si:ch211-120k19.1; Belongs to the peroxisomal membrane protein PXMP2/4 family.	ATP-binding cassette, sub-family D (ALD), member 2.	0.406
LOC103479635	ENSPREP00000020277	ENSPREP00000009477	ENSPREP00000020277	Death domain-containing protein.	RBR-type E3 ubiquitin transferase.	0.473
LOC103479635	LOC103466013	ENSPREP00000009477	ENSPREP00000021307	Death domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.997
LOC103479635	atg5	ENSPREP00000009477	ENSPREP00000028618	Death domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.525
LOC103481546	dhfr	ENSPREP00000007486	ENSPREP00000017926	GTP cyclohydrolase 2.	Dihydrofolate reductase.	0.468
LOC103481546	gch1	ENSPREP00000007486	ENSPREP00000027524	GTP cyclohydrolase 2.	GTP cyclohydrolase 1.	0.901