(31 nodes) Regulation of CD4-positive, alpha-beta T cell activation network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	vsir	V-set immunoregulatory receptor. (291 aa)
	itch	E3 ubiquitin-protein ligase. (840 aa)
	LOC103469798	SCY domain-containing protein. (110 aa)
	ENSPREP00000004255	ANK_REP_REGION domain-containing protein. (314 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (623 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	snx12	Fibronectin type-III domain-containing protein. (355 aa)
	ENSPREP00000010806	Galectin. (325 aa)
	LOC103466618	MALT paracaspase 3. (573 aa)
	LOC103469935	MALT paracaspase 1. (828 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1110 aa)
	ENSPREP00000013399	Uncharacterized protein. (453 aa)
	ENSPREP00000014507	UBA_6 domain-containing protein. (200 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
	myb	V-myb avian myeloblastosis viral oncogene homolog. (597 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	ENSPREP00000018176	Uncharacterized protein. (394 aa)
	ENSPREP00000018398	MALT paracaspase 2. (715 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	ENSPREP00000021306	Si:dkeyp-44d3.5. (895 aa)
	LOC103464828	E3 ubiquitin-protein ligase. (869 aa)
	IL18	Uncharacterized protein. (218 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1119 aa)
	TGFBR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
	cd83	CD83 molecule. (228 aa)
	ENSPREP00000027430	CARD domain-containing protein. (524 aa)
	LOC103468544	Guanylate kinase-like domain-containing protein. (308 aa)
	cbfb	Core-binding factor subunit beta. (184 aa)
	sh3rf1	SH3 domain containing ring finger 1. (849 aa)
	LOC103477681	ANK_REP_REGION domain-containing protein. (435 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010806	ENSPREP00000013399	ENSPREP00000010806	ENSPREP00000013399	Galectin.	Uncharacterized protein.	0.491
ENSPREP00000013399	ENSPREP00000010806	ENSPREP00000013399	ENSPREP00000010806	Uncharacterized protein.	Galectin.	0.491
ENSPREP00000014507	LOC103477681	ENSPREP00000014507	ENSPREP00000027821	UBA_6 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.432
ENSPREP00000014507	rc3h1	ENSPREP00000014507	ENSPREP00000025906	UBA_6 domain-containing protein.	Ring finger and CCCH-type domains 1b.	0.406
ENSPREP00000018398	ENSPREP00000027430	ENSPREP00000018398	ENSPREP00000027430	MALT paracaspase 2.	CARD domain-containing protein.	0.784
ENSPREP00000018398	LOC103468544	ENSPREP00000018398	ENSPREP00000027446	MALT paracaspase 2.	Guanylate kinase-like domain-containing protein.	0.784
ENSPREP00000027430	ENSPREP00000018398	ENSPREP00000027430	ENSPREP00000018398	CARD domain-containing protein.	MALT paracaspase 2.	0.784
ENSPREP00000027430	LOC103466618	ENSPREP00000027430	ENSPREP00000011487	CARD domain-containing protein.	MALT paracaspase 3.	0.784
ENSPREP00000027430	LOC103468544	ENSPREP00000027430	ENSPREP00000027446	CARD domain-containing protein.	Guanylate kinase-like domain-containing protein.	0.900
ENSPREP00000027430	LOC103469935	ENSPREP00000027430	ENSPREP00000011835	CARD domain-containing protein.	MALT paracaspase 1.	0.784
ENSPREP00000027430	ripk2	ENSPREP00000027430	ENSPREP00000009886	CARD domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.489
LOC103464828	itch	ENSPREP00000023584	ENSPREP00000001984	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC103464828	ripk2	ENSPREP00000023584	ENSPREP00000009886	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.573
LOC103466618	ENSPREP00000027430	ENSPREP00000011487	ENSPREP00000027430	MALT paracaspase 3.	CARD domain-containing protein.	0.784
LOC103466618	LOC103468544	ENSPREP00000011487	ENSPREP00000027446	MALT paracaspase 3.	Guanylate kinase-like domain-containing protein.	0.784
LOC103466618	LOC103469935	ENSPREP00000011487	ENSPREP00000011835	MALT paracaspase 3.	MALT paracaspase 1.	0.902
LOC103468544	ENSPREP00000018398	ENSPREP00000027446	ENSPREP00000018398	Guanylate kinase-like domain-containing protein.	MALT paracaspase 2.	0.784
LOC103468544	ENSPREP00000027430	ENSPREP00000027446	ENSPREP00000027430	Guanylate kinase-like domain-containing protein.	CARD domain-containing protein.	0.900
LOC103468544	LOC103466618	ENSPREP00000027446	ENSPREP00000011487	Guanylate kinase-like domain-containing protein.	MALT paracaspase 3.	0.784
LOC103468544	LOC103469935	ENSPREP00000027446	ENSPREP00000011835	Guanylate kinase-like domain-containing protein.	MALT paracaspase 1.	0.784