(34 nodes) Regulation of stem cell differentiation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pwp1	PWP1 homolog, endonuclein. (493 aa)
	LOC103478593	RNA binding motif protein 24b. (238 aa)
	hspa9	Heat shock protein 9; Belongs to the heat shock protein 70 family. (679 aa)
	nudt21	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (229 aa)
	cdk13	Cyclin-dependent kinase 13. (1409 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1057 aa)
	sox5	SRY-box transcription factor 5. (807 aa)
	LOC103465716	HMG box domain-containing protein. (783 aa)
	ENSPREP00000007854	Uncharacterized protein. (143 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (617 aa)
	fgfr4	Fibroblast growth factor receptor 4. (942 aa)
	LOC103458160	Fibroblast growth factor receptor. (814 aa)
	bbs12	Bardet-Biedl syndrome 12. (622 aa)
	slc4a11	Solute carrier family 4 member 11. (855 aa)
	supt5h	Transcription elongation factor SPT5. (1059 aa)
	LOC103472384	RNA binding motif protein 24a. (242 aa)
	LOC103477270	Uncharacterized protein. (689 aa)
	ENSPREP00000011628	Uncharacterized protein. (564 aa)
	LOC103477355	Protein kinase domain-containing protein. (582 aa)
	ENSPREP00000013954	Uncharacterized protein. (326 aa)
	LOC103477293	Fibroblast growth factor receptor. (676 aa)
	epcam	Epithelial cell adhesion molecule. (309 aa)
	LOC103480536	Methyltransferase like 3; Belongs to the MT-A70-like family. (287 aa)
	cdk12	Cyclin-dependent kinase 12. (1352 aa)
	LOC103468660	Uncharacterized protein. (252 aa)
	SLC4A11	Solute carrier family 4 member 11. (852 aa)
	smyd5	SMYD family member 5. (414 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	nsun2	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (751 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	pus7	Pseudouridine synthase 7. (641 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (639 aa)
	nkx2-5	NK2 homeobox 5. (316 aa)
	LOC103462437	SRY-box transcription factor 6. (779 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000007854	LOC103480536	ENSPREP00000007854	ENSPREP00000015801	Uncharacterized protein.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.899
ENSPREP00000007854	nsun2	ENSPREP00000007854	ENSPREP00000025900	Uncharacterized protein.	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.413
LOC103462437	sox5	ENSPREP00000033960	ENSPREP00000005158	SRY-box transcription factor 6.	SRY-box transcription factor 5.	0.635
LOC103465716	sox5	ENSPREP00000006457	ENSPREP00000005158	HMG box domain-containing protein.	SRY-box transcription factor 5.	0.633
LOC103477270	nfe2l2	ENSPREP00000011565	ENSPREP00000007937	Uncharacterized protein.	Nuclear factor, erythroid 2-like 2a.	0.914
LOC103480536	ENSPREP00000007854	ENSPREP00000015801	ENSPREP00000007854	Methyltransferase like 3; Belongs to the MT-A70-like family.	Uncharacterized protein.	0.899
LOC103480536	nsun2	ENSPREP00000015801	ENSPREP00000025900	Methyltransferase like 3; Belongs to the MT-A70-like family.	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.413
LOC103480536	ythdf2	ENSPREP00000015801	ENSPREP00000028675	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.506
cdk12	supt5h	ENSPREP00000016181	ENSPREP00000009918	Cyclin-dependent kinase 12.	Transcription elongation factor SPT5.	0.946
cdk13	supt5h	ENSPREP00000002742	ENSPREP00000009918	Cyclin-dependent kinase 13.	Transcription elongation factor SPT5.	0.946
nfe2l2	LOC103477270	ENSPREP00000007937	ENSPREP00000011565	Nuclear factor, erythroid 2-like 2a.	Uncharacterized protein.	0.914
nsun2	ENSPREP00000007854	ENSPREP00000025900	ENSPREP00000007854	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	Uncharacterized protein.	0.413
nsun2	LOC103480536	ENSPREP00000025900	ENSPREP00000015801	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.413
nsun2	pus7	ENSPREP00000025900	ENSPREP00000028214	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	Pseudouridine synthase 7.	0.789
nsun2	pwp1	ENSPREP00000025900	ENSPREP00000017780	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	PWP1 homolog, endonuclein.	0.520
pus7	nsun2	ENSPREP00000028214	ENSPREP00000025900	Pseudouridine synthase 7.	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.789
pus7	pwp1	ENSPREP00000028214	ENSPREP00000017780	Pseudouridine synthase 7.	PWP1 homolog, endonuclein.	0.507
pwp1	nsun2	ENSPREP00000017780	ENSPREP00000025900	PWP1 homolog, endonuclein.	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.520
pwp1	pus7	ENSPREP00000017780	ENSPREP00000028214	PWP1 homolog, endonuclein.	Pseudouridine synthase 7.	0.507
sox5	LOC103462437	ENSPREP00000005158	ENSPREP00000033960	SRY-box transcription factor 5.	SRY-box transcription factor 6.	0.635