(74 nodes) Histone deacetylase complex network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Brd8	Si:ch211-59d17.3. (522 aa)
	hdac6	Histone deacetylase 6. (899 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1105 aa)
	LOC103474968	Histone deacetylase 12. (345 aa)
	ENSPREP00000018784	Uncharacterized protein. (565 aa)
	LOC103472838	Chromodomain helicase DNA binding protein 4a. (1967 aa)
	ncor2	Nuclear receptor corepressor 2. (2291 aa)
	LOC103459281	Transducin beta like 1 X-linked. (513 aa)
	ep400	E1A binding protein p400. (3065 aa)
	LOC103467053	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (821 aa)
	LOC103458631	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	LOC103464932	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (923 aa)
	hdac9	Histone deacetylase 9b. (631 aa)
	aire	Autoimmune regulator. (496 aa)
	LOC103480197	GATA-type domain-containing protein. (406 aa)
	LOC103471057	Bromodomain containing 8. (603 aa)
	ENSPREP00000006402	Uncharacterized protein. (79 aa)
	suds3	SDS3 homolog, SIN3A corepressor complex component. (318 aa)
	LOC103462700	SIN3 transcription regulator family member Ab. (1299 aa)
	mta3	Metastasis associated 1 family, member 3. (699 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1136 aa)
	LOC103479069	Transducin (beta)-like 1 X-linked receptor 1b. (514 aa)
	ncor1	Nuclear receptor corepressor 1. (2343 aa)
	LOC103463694	GATA zinc finger domain containing 2Ab. (591 aa)
	brms1l	Uncharacterized protein. (272 aa)
	LOC103462110	MRG domain-containing protein. (280 aa)
	arid4b	Translocase of outer mitochondrial membrane 20. (1318 aa)
	ENSPREP00000012311	Uncharacterized protein. (769 aa)
	LOC103463654	Methyl-CpG binding domain protein 3a. (274 aa)
	ENSPREP00000014193	Reverse transcriptase domain-containing protein. (486 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (435 aa)
	LOC103466532	Mortality factor 4 like 1. (315 aa)
	sin3a	SIN3 transcription regulator family member Aa. (1318 aa)
	chd3	Chromodomain helicase DNA binding protein 3. (1830 aa)
	chd4	Uncharacterized protein. (1981 aa)
	ENSPREP00000034257	Uncharacterized protein. (859 aa)
	LOC103462457	SIN3-HDAC complex associated factor, like. (221 aa)
	ing1	Inhibitor of growth protein. (304 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (422 aa)
	Kmt2e	Lysine (K)-specific methyltransferase 2E. (602 aa)
	rbbp4	Retinoblastoma binding protein 4. (424 aa)
	znf217	Zinc finger protein 217. (936 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
	setd5	SET domain containing 5. (1201 aa)
	phf21a	PHD finger protein 21Ab. (783 aa)
	hdac11	Histone deacetylase 11. (367 aa)
	actr6	Actin related protein 6; Belongs to the actin family. (397 aa)
	brms1	BRMS1 transcriptional repressor and anoikis regulator. (293 aa)
	gatad2b	GATA zinc finger domain containing 2B. (589 aa)
	ENSPREP00000028591	Uncharacterized protein. (79 aa)
	hdac10	Histone deacetylase 10. (665 aa)
	ing3	Inhibitor of growth protein. (418 aa)
	LOC103457806	BRMS1 like transcriptional repressor b. (324 aa)
	LOC103479433	Uncharacterized protein. (621 aa)
	sin3b	SIN3 transcription regulator family member B. (1278 aa)
	LOC103479450	Uncharacterized protein. (251 aa)
	LOC103469771	Zinc finger protein 703. (579 aa)
	ENSPREP00000025570	Endo/exonuclease/phosphatase domain-containing protein. (471 aa)
	LOC103472045	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	LOC103461731	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1063 aa)
	LOC103466071	SIN3-HDAC complex associated factor. (276 aa)
	anp32e	Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E. (247 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (483 aa)
	sap130	Sin3A-associated protein a. (1055 aa)
	ENSPREP00000022569	Ubiquitin-conjugating enzyme E2C. (290 aa)
	LOC103477476	Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E. (229 aa)
	phf12	PHD finger protein 12b. (1007 aa)
	chd5	Uncharacterized protein. (1804 aa)
	sap30l	Sap30-like. (178 aa)
	mta1	Metastasis associated 1. (584 aa)
	LOC103460256	Methyl-CpG binding domain protein 2. (302 aa)
	srcap	Snf2-related CREBBP activator protein. (3939 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	LOC103460987	Metastasis associated 1 family, member 2. (332 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brd8	ENSPREP00000006402	ENSPREP00000028553	ENSPREP00000006402	Si:ch211-59d17.3.	Uncharacterized protein.	0.933
Brd8	ENSPREP00000028591	ENSPREP00000028553	ENSPREP00000028591	Si:ch211-59d17.3.	Uncharacterized protein.	0.933
Brd8	LOC103462110	ENSPREP00000028553	ENSPREP00000011728	Si:ch211-59d17.3.	MRG domain-containing protein.	0.727
Brd8	LOC103466532	ENSPREP00000028553	ENSPREP00000016069	Si:ch211-59d17.3.	Mortality factor 4 like 1.	0.727
Brd8	dmap1	ENSPREP00000028553	ENSPREP00000023811	Si:ch211-59d17.3.	DNA methyltransferase 1 associated protein 1.	0.802
Brd8	ep400	ENSPREP00000028553	ENSPREP00000001971	Si:ch211-59d17.3.	E1A binding protein p400.	0.584
Brd8	ing3	ENSPREP00000028553	ENSPREP00000028076	Si:ch211-59d17.3.	Inhibitor of growth protein.	0.716
Brd8	srcap	ENSPREP00000028553	ENSPREP00000019672	Si:ch211-59d17.3.	Snf2-related CREBBP activator protein.	0.584
ENSPREP00000006402	Brd8	ENSPREP00000006402	ENSPREP00000028553	Uncharacterized protein.	Si:ch211-59d17.3.	0.933
ENSPREP00000006402	LOC103462110	ENSPREP00000006402	ENSPREP00000011728	Uncharacterized protein.	MRG domain-containing protein.	0.727
ENSPREP00000006402	LOC103466532	ENSPREP00000006402	ENSPREP00000016069	Uncharacterized protein.	Mortality factor 4 like 1.	0.727
ENSPREP00000006402	LOC103471057	ENSPREP00000006402	ENSPREP00000006352	Uncharacterized protein.	Bromodomain containing 8.	0.932
ENSPREP00000006402	dmap1	ENSPREP00000006402	ENSPREP00000023811	Uncharacterized protein.	DNA methyltransferase 1 associated protein 1.	0.802
ENSPREP00000006402	ep400	ENSPREP00000006402	ENSPREP00000001971	Uncharacterized protein.	E1A binding protein p400.	0.584
ENSPREP00000006402	ing3	ENSPREP00000006402	ENSPREP00000028076	Uncharacterized protein.	Inhibitor of growth protein.	0.716
ENSPREP00000006402	srcap	ENSPREP00000006402	ENSPREP00000019672	Uncharacterized protein.	Snf2-related CREBBP activator protein.	0.584
ENSPREP00000014193	ENSPREP00000025570	ENSPREP00000014193	ENSPREP00000025570	Reverse transcriptase domain-containing protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.543
ENSPREP00000018784	HDAC2	ENSPREP00000018784	ENSPREP00000030998	Uncharacterized protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.760
ENSPREP00000018784	HDAC4	ENSPREP00000018784	ENSPREP00000018575	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.565
ENSPREP00000018784	LOC103458631	ENSPREP00000018784	ENSPREP00000002417	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.760