(47 nodes) Ruffle network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AIF1	Allograft inflammatory factor 1. (149 aa)
	LOC103461231	Protein kinase C and casein kinase substrate in neurons 1a. (441 aa)
	psd2	Pleckstrin and Sec7 domain containing 2. (895 aa)
	LOC103482172	Nucleoside diphosphate kinase. (153 aa)
	c2cd5	C2 calcium dependent domain containing 5. (1071 aa)
	itgb1	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	LOC103476047	Sprouty RTK signaling antagonist 2. (349 aa)
	LOC103474901	Inositol polyphosphate-5-phosphatase Ka. (535 aa)
	LOC103473692	Inositol polyphosphate-5-phosphatase Ja. (536 aa)
	ENSPREP00000015747	Uncharacterized protein. (47 aa)
	LOC103468968	Si:ch211-51c14.1. (389 aa)
	EPS8L2	EPS8 like 2. (691 aa)
	kank3	KN motif and ankyrin repeat domains 3. (988 aa)
	LOC103477395	Pleckstrin and Sec7 domain containing a. (505 aa)
	LOC103464724	Protein kinase C and casein kinase substrate in neurons 1b. (484 aa)
	wwc1	WW and C2 domain containing 1. (1125 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (345 aa)
	LOC103481754	Uncharacterized protein. (1569 aa)
	LOC103473807	Uncharacterized protein. (1110 aa)
	ENSPREP00000021963	LIM zinc-binding domain-containing protein. (129 aa)
	plek	Pleckstrin. (351 aa)
	als2	Alsin Rho guanine nucleotide exchange factor ALS2 b. (1671 aa)
	LOC103475499	Inositol polyphosphate-5-phosphatase Kb. (522 aa)
	plekha1	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b. (333 aa)
	LOC103461174	Uncharacterized protein. (1222 aa)
	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (894 aa)
	kank1	KN motif and ankyrin repeat domains 1. (1292 aa)
	LOC103469154	SH3 domain-containing protein. (535 aa)
	LOC103469155	Nucleoside diphosphate kinase. (236 aa)
	mkln1	Muskelin 1, intracellular mediator containing kelch motifs. (742 aa)
	LOC103481049	Eps8 like 1b. (457 aa)
	LOC103481055	Zgc:91999. (394 aa)
	pacsin3	Protein kinase C and casein kinase substrate in neurons 3. (444 aa)
	eps8	Epidermal growth factor receptor pathway substrate 8a. (746 aa)
	LOC103479472	Integrin beta; Belongs to the integrin beta chain family. (796 aa)
	nme6	Nucleoside diphosphate kinase. (182 aa)
	lima1	LIM domain and actin binding 1a. (617 aa)
	LOC103473351	KN motif and ankyrin repeat domains 1b. (1246 aa)
	LOC103464244	Uncharacterized protein. (173 aa)
	ENSPREP00000031515	LIM zinc-binding domain-containing protein. (211 aa)
	ENSPREP00000031527	Uncharacterized protein. (1802 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1214 aa)
	LOC103470276	Inositol polyphosphate-5-phosphatase Jb. (602 aa)
	aif1l	Allograft inflammatory factor 1-like. (153 aa)
	Sh3yl1	SH3 and SYLF domain containing 1. (188 aa)
	pacsin2	Protein kinase C and casein kinase substrate in neurons 2. (442 aa)
	arfgap3	ADP-ribosylation factor GTPase activating protein 3. (524 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103461174	LOC103477395	ENSPREP00000023408	ENSPREP00000018944	Uncharacterized protein.	Pleckstrin and Sec7 domain containing a.	0.811
LOC103469155	LOC103482172	ENSPREP00000024280	ENSPREP00000006159	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.929
LOC103469155	nme6	ENSPREP00000024280	ENSPREP00000028503	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.933
LOC103473692	LOC103474901	ENSPREP00000015723	ENSPREP00000014303	Inositol polyphosphate-5-phosphatase Ja.	Inositol polyphosphate-5-phosphatase Ka.	0.900
LOC103473692	LOC103475499	ENSPREP00000015723	ENSPREP00000022548	Inositol polyphosphate-5-phosphatase Ja.	Inositol polyphosphate-5-phosphatase Kb.	0.900
LOC103474901	LOC103473692	ENSPREP00000014303	ENSPREP00000015723	Inositol polyphosphate-5-phosphatase Ka.	Inositol polyphosphate-5-phosphatase Ja.	0.900
LOC103474901	LOC103475499	ENSPREP00000014303	ENSPREP00000022548	Inositol polyphosphate-5-phosphatase Ka.	Inositol polyphosphate-5-phosphatase Kb.	0.901
LOC103475499	LOC103473692	ENSPREP00000022548	ENSPREP00000015723	Inositol polyphosphate-5-phosphatase Kb.	Inositol polyphosphate-5-phosphatase Ja.	0.900
LOC103475499	LOC103474901	ENSPREP00000022548	ENSPREP00000014303	Inositol polyphosphate-5-phosphatase Kb.	Inositol polyphosphate-5-phosphatase Ka.	0.901
LOC103477395	LOC103461174	ENSPREP00000018944	ENSPREP00000023408	Pleckstrin and Sec7 domain containing a.	Uncharacterized protein.	0.811
LOC103479472	itgb1	ENSPREP00000028258	ENSPREP00000008737	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.901
LOC103482172	LOC103469155	ENSPREP00000006159	ENSPREP00000024280	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.929
LOC103482172	nme6	ENSPREP00000006159	ENSPREP00000028503	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.918
itgb1	LOC103479472	ENSPREP00000008737	ENSPREP00000028258	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.901
nme6	LOC103469155	ENSPREP00000028503	ENSPREP00000024280	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.933
nme6	LOC103482172	ENSPREP00000028503	ENSPREP00000006159	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.918