(53 nodes) Photoreceptor outer segment network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDHR1	Cadherin related family member 1. (879 aa)
	LOC103459922	Guanylate cyclase activator 1d. (178 aa)
	LOC103465677	Guanylate cyclase. (954 aa)
	LOC103472623	Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (657 aa)
	LOC103464571	Rhodopsin. (362 aa)
	ENSPREP00000004318	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	pde6g	Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a. (90 aa)
	PPEF2	Serine/threonine-protein phosphatase with EF-hands. (713 aa)
	LOC103466329	Parietopsin. (350 aa)
	guca1b	Guanylate cyclase activator 1B. (211 aa)
	LOC103474780	Guanylate cyclase. (1100 aa)
	LOC103476014	Retinal outer segment membrane protein 1a. (347 aa)
	LOC103480256	Guanylate cyclase. (1136 aa)
	ENSPREP00000009710	Uncharacterized protein. (2328 aa)
	grk7	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (557 aa)
	rd3	Retinal degeneration 3, GUCY2D regulator. (215 aa)
	LOC103481584	Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b. (80 aa)
	spata7	Uncharacterized protein. (583 aa)
	pde6a	Phosphodiesterase. (873 aa)
	LOC103469928	Serine/threonine-protein phosphatase with EF-hands. (747 aa)
	rp1l1	Rp1 like 1a. (2396 aa)
	LOC103457384	Solute carrier family 24 member 4b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (593 aa)
	LOC103473654	Phosphodiesterase. (854 aa)
	LOC103480034	Teleost multiple tissue opsin 2b. (376 aa)
	rpgr	Uncharacterized protein. (1381 aa)
	LOC103458452	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class). (354 aa)
	LOC103463549	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class). (359 aa)
	LOC108165778	Uncharacterized protein. (73 aa)
	dhrs3	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	RHO	Extra-ocular rhodopsin. (391 aa)
	rom1	Retinal outer segment membrane protein 1b. (361 aa)
	ENSPREP00000023767	Uncharacterized protein. (48 aa)
	pde6h	Uncharacterized protein. (86 aa)
	LOC103463002	Uncharacterized protein. (195 aa)
	rho	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (350 aa)
	LOC103463003	Guanylate cyclase activator 1g. (187 aa)
	ENSPREP00000024137	Uncharacterized protein. (71 aa)
	ENSPREP00000024139	RP1 axonemal microtubule associated. (235 aa)
	LOC103457850	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (345 aa)
	ENSPREP00000025255	Uncharacterized protein. (184 aa)
	LOC103476850	Cadherin-related family member 1a. (868 aa)
	LOC103474448	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (545 aa)
	ENSPREP00000028127	Doublecortin domain-containing protein. (4436 aa)
	ppef1	Serine/threonine-protein phosphatase with EF-hands. (751 aa)
	LOC103456755	Teleost multiple tissue opsin b; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	pde6c	Phosphodiesterase. (853 aa)
	LOC103475785	Guanylate cyclase. (1151 aa)
	guca1a	Guanylate cyclase activator 1A. (182 aa)
	cfap410	Cilia and flagella associated protein 410. (252 aa)
	LOC103476508	Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (642 aa)
	LOC103462899	Uncharacterized protein. (194 aa)
	opn5	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	lyar	Ly1 antibody reactive homolog (mouse). (322 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000028127	guca1a	ENSPREP00000028127	ENSPREP00000032624	Doublecortin domain-containing protein.	Guanylate cyclase activator 1A.	0.408
LOC103458452	LOC103474448	ENSPREP00000015705	ENSPREP00000027131	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.431
LOC103458452	grk7	ENSPREP00000015705	ENSPREP00000010652	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.431
LOC103459922	grk7	ENSPREP00000002113	ENSPREP00000010652	Guanylate cyclase activator 1d.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.426
LOC103459922	pde6g	ENSPREP00000002113	ENSPREP00000004512	Guanylate cyclase activator 1d.	Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a.	0.426
LOC103462899	LOC103465677	ENSPREP00000029999	ENSPREP00000003281	Uncharacterized protein.	Guanylate cyclase.	0.913
LOC103462899	LOC103474780	ENSPREP00000029999	ENSPREP00000007914	Uncharacterized protein.	Guanylate cyclase.	0.910
LOC103462899	LOC103480256	ENSPREP00000029999	ENSPREP00000008988	Uncharacterized protein.	Guanylate cyclase.	0.910
LOC103463002	LOC103465677	ENSPREP00000023997	ENSPREP00000003281	Uncharacterized protein.	Guanylate cyclase.	0.905
LOC103463002	LOC103474780	ENSPREP00000023997	ENSPREP00000007914	Uncharacterized protein.	Guanylate cyclase.	0.905
LOC103463002	LOC103480256	ENSPREP00000023997	ENSPREP00000008988	Uncharacterized protein.	Guanylate cyclase.	0.905
LOC103463003	LOC103465677	ENSPREP00000024109	ENSPREP00000003281	Guanylate cyclase activator 1g.	Guanylate cyclase.	0.905
LOC103463003	LOC103474780	ENSPREP00000024109	ENSPREP00000007914	Guanylate cyclase activator 1g.	Guanylate cyclase.	0.905
LOC103463003	LOC103480256	ENSPREP00000024109	ENSPREP00000008988	Guanylate cyclase activator 1g.	Guanylate cyclase.	0.905
LOC103463549	LOC103474448	ENSPREP00000017763	ENSPREP00000027131	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class).	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.431
LOC103463549	grk7	ENSPREP00000017763	ENSPREP00000010652	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class).	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.431
LOC103464571	LOC103469928	ENSPREP00000004006	ENSPREP00000011678	Rhodopsin.	Serine/threonine-protein phosphatase with EF-hands.	0.489
LOC103464571	LOC103474448	ENSPREP00000004006	ENSPREP00000027131	Rhodopsin.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.957
LOC103464571	PPEF2	ENSPREP00000004006	ENSPREP00000004962	Rhodopsin.	Serine/threonine-protein phosphatase with EF-hands.	0.489
LOC103464571	grk7	ENSPREP00000004006	ENSPREP00000010652	Rhodopsin.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.957