(59 nodes) Bicellular tight junction network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000027521	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (147 aa)
	LOC103475799	F11 receptor, tandem duplicate 1. (308 aa)
	LOC103462420	Tight junction protein 1a; Belongs to the MAGUK family. (1693 aa)
	c1qtnf5	C1q and TNF related 5. (250 aa)
	ENSPREP00000027294	Uncharacterized protein. (117 aa)
	LOC103480976	Uncharacterized protein. (750 aa)
	ENSPREP00000000467	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	ENSPREP00000002240	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (76 aa)
	cldn10	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	ENSPREP00000003364	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (133 aa)
	dlg5	Discs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (1988 aa)
	LOC103475300	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
	LOC103468796	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	clmp	Uncharacterized protein. (385 aa)
	ENSPREP00000006660	Uncharacterized protein. (540 aa)
	ENSPREP00000006767	Uncharacterized protein. (705 aa)
	ENSPREP00000008469	Uncharacterized protein. (312 aa)
	LOC103473567	Claudin 23a. (257 aa)
	tjp2	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1077 aa)
	tjp3	Tight junction protein 3; Belongs to the MAGUK family. (1306 aa)
	LOC103476642	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (725 aa)
	LOC103479092	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	mtdh	Metadherin a. (519 aa)
	ENSPREP00000013716	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (112 aa)
	ENSPREP00000013809	Claudin b. (126 aa)
	ENSPREP00000013822	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (188 aa)
	ENSPREP00000013895	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (173 aa)
	LOC103475617	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (205 aa)
	PMP22	Peripheral myelin protein 22b. (108 aa)
	ENSPREP00000015306	Ig-like domain-containing protein. (307 aa)
	MPDZ	Si:dkey-92j12.5. (1912 aa)
	cldn11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	LOC103458410	Claudin 11a. (219 aa)
	Cldn14	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (187 aa)
	ENSPREP00000019404	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (145 aa)
	LOC103474412	Si:busm1-52i16.2. (345 aa)
	pof1b	POF1B actin binding protein. (570 aa)
	ENSPREP00000020177	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (257 aa)
	Cldn2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (195 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	frmpd2	FERM and PDZ domain containing 2. (1149 aa)
	LOC103472710	Cingulin b. (1169 aa)
	LOC103475125	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (247 aa)
	MPDZ-2	Multiple PDZ domain crumbs cell polarity complex component. (2132 aa)
	ENSPREP00000025381	Rho-GAP domain-containing protein. (127 aa)
	LOC103478155	Cingulin a. (1200 aa)
	LOC103464131	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (203 aa)
	LOC103466442	Tight junction protein 1b; Belongs to the MAGUK family. (1954 aa)
	LOC103480588	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC103473229	Occludin a. (496 aa)
	ENSPREP00000024586	Angiomotin. (962 aa)
	LOC103466075	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1538 aa)
	LOC103478193	Uncharacterized protein. (433 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1287 aa)
	ENSPREP00000027703	Uncharacterized protein. (161 aa)
	ENSPREP00000027691	Uncharacterized protein. (171 aa)
	ENSPREP00000027565	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn14	Cldn2	ENSPREP00000019367	ENSPREP00000020370	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
Cldn14	Cldn5	ENSPREP00000019367	ENSPREP00000017247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.662
Cldn14	ENSPREP00000003364	ENSPREP00000019367	ENSPREP00000003364	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.660
Cldn14	ENSPREP00000008469	ENSPREP00000019367	ENSPREP00000008469	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.682
Cldn14	ENSPREP00000013716	ENSPREP00000019367	ENSPREP00000013716	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.668
Cldn14	ENSPREP00000013809	ENSPREP00000019367	ENSPREP00000013809	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin b.	0.670
Cldn14	ENSPREP00000013895	ENSPREP00000019367	ENSPREP00000013895	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.673
Cldn14	ENSPREP00000019404	ENSPREP00000019367	ENSPREP00000019404	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.660
Cldn14	ENSPREP00000027294	ENSPREP00000019367	ENSPREP00000027294	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.667
Cldn14	ENSPREP00000027521	ENSPREP00000019367	ENSPREP00000027521	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.673
Cldn14	ENSPREP00000027565	ENSPREP00000019367	ENSPREP00000027565	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.663
Cldn14	ENSPREP00000027703	ENSPREP00000019367	ENSPREP00000027703	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.682
Cldn14	LOC103458410	ENSPREP00000019367	ENSPREP00000018934	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 11a.	0.677
Cldn14	LOC103462420	ENSPREP00000019367	ENSPREP00000033787	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.715
Cldn14	LOC103464131	ENSPREP00000019367	ENSPREP00000022771	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.665
Cldn14	LOC103466442	ENSPREP00000019367	ENSPREP00000022800	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.715
Cldn14	LOC103468796	ENSPREP00000019367	ENSPREP00000005908	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.691
Cldn14	LOC103473180	ENSPREP00000019367	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.662
Cldn14	LOC103473567	ENSPREP00000019367	ENSPREP00000008843	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 23a.	0.674
Cldn14	LOC103475125	ENSPREP00000019367	ENSPREP00000027247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.696