(65 nodes) Histone methyltransferase complex network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	aebp2	AE binding protein 2. (464 aa)
	LOC103460221	CXXC finger protein 1a. (599 aa)
	paxip1	PAX interacting (with transcription-activation domain) protein 1. (1084 aa)
	LOC103457059	THAP-type domain-containing protein. (377 aa)
	ENSPREP00000017849	WD40 repeat domain 95. (587 aa)
	setd1b	SET domain containing 1B, histone lysine methyltransferase a. (1816 aa)
	LOC103475867	Lysine (K)-specific demethylase 6B, b. (1729 aa)
	Hcfc2	Host cell factor C2. (270 aa)
	ENSPREP00000023487	Uncharacterized protein. (378 aa)
	eed	Embryonic ectoderm development. (443 aa)
	ash2l	Ash2 like, histone lysine methyltransferase complex subunit. (593 aa)
	kdm6b	Lysine (K)-specific demethylase 6B, a. (2105 aa)
	ENSPREP00000020329	Uncharacterized protein. (1729 aa)
	LOC103469057	VEFS-Box domain-containing protein. (706 aa)
	ENSPREP00000019006	Uncharacterized protein. (116 aa)
	phf19	PHD finger protein 19. (546 aa)
	LOC103473596	Transmembrane protein 182b. (260 aa)
	phf1	PHD finger protein 1. (546 aa)
	mycl	MYCL proto-oncogene, bHLH transcription factor b. (414 aa)
	LOC103467472	Nuclear receptor coactivator 6. (2360 aa)
	tex10	Testis expressed 10. (941 aa)
	MAX	MYC associated factor X. (150 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1447 aa)
	kmt2d	Lysine (K)-specific methyltransferase 2D. (3999 aa)
	cxxc1	CXXC finger protein 1b. (569 aa)
	RING1	Ring finger protein 1. (392 aa)
	chd8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2620 aa)
	LOC103470930	Uncharacterized protein. (250 aa)
	rbbp4	Retinoblastoma binding protein 4. (424 aa)
	KMT2A	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3484 aa)
	LOC103465550	Host cell factor C1a. (1756 aa)
	wdr5	WD repeat domain 5. (297 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (422 aa)
	Phf20	Uncharacterized protein. (94 aa)
	pagr1	PAXIP1 associated glutamate-rich protein 1. (277 aa)
	rnf2	Ring finger protein 2. (342 aa)
	LOC103459858	Zgc:103508. (205 aa)
	pelp1	Proline, glutamate and leucine rich protein 1. (1272 aa)
	kmt2b	Lysine (K)-specific methyltransferase 2Bb. (3857 aa)
	AEBP2	AE binding protein 2. (501 aa)
	men1	Multiple endocrine neoplasia I. (627 aa)
	LOC103479582	Lysine (K)-specific methyltransferase 2Cb. (4978 aa)
	LOC103458130	BHLH domain-containing protein. (3008 aa)
	ENSPREP00000006739	Uncharacterized protein. (103 aa)
	wdr82	WD repeat domain 82. (302 aa)
	dpy30	Dpy-30 histone methyltransferase complex regulatory subunit. (150 aa)
	mxd3	MAX dimerization protein 3. (200 aa)
	LOC103465138	Uncharacterized protein. (603 aa)
	rnf166	Ring finger protein 166. (244 aa)
	mtf2	Metal response element binding transcription factor 2. (622 aa)
	jarid2	Jumonji, AT rich interactive domain 2b. (1446 aa)
	tmem182	Transmembrane protein 182a. (246 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (770 aa)
	ENSPREP00000014132	Uncharacterized protein. (138 aa)
	LOC103475798	Lysine (K)-specific demethylase 6A, like. (1466 aa)
	rbbp5	Retinoblastoma binding protein 5. (564 aa)
	setd1a	SET domain containing 1A, histone lysine methyltransferase. (2165 aa)
	ENSPREP00000015321	Myc associated factor X. (163 aa)
	LOC103470662	Uncharacterized protein. (1549 aa)
	Kmt2c	Uncharacterized protein. (741 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
	ENSPREP00000015954	Uncharacterized protein. (397 aa)
	ENSPREP00000016356	Uncharacterized protein. (144 aa)
	LOC103468858	SUZ12 polycomb repressive complex 2 subunit b. (705 aa)
	ENSPREP00000018826	Fibronectin type-III domain-containing protein. (255 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEBP2	ENSPREP00000014132	ENSPREP00000005569	ENSPREP00000014132	AE binding protein 2.	Uncharacterized protein.	0.802
AEBP2	EZH1	ENSPREP00000005569	ENSPREP00000013900	AE binding protein 2.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.802
AEBP2	LOC103468858	ENSPREP00000005569	ENSPREP00000018755	AE binding protein 2.	SUZ12 polycomb repressive complex 2 subunit b.	0.907
AEBP2	LOC103469057	ENSPREP00000005569	ENSPREP00000019458	AE binding protein 2.	VEFS-Box domain-containing protein.	0.905
AEBP2	LOC103475798	ENSPREP00000005569	ENSPREP00000014271	AE binding protein 2.	Lysine (K)-specific demethylase 6A, like.	0.401
AEBP2	LOC103475867	ENSPREP00000005569	ENSPREP00000002425	AE binding protein 2.	Lysine (K)-specific demethylase 6B, b.	0.471
AEBP2	RBBP7	ENSPREP00000005569	ENSPREP00000032935	AE binding protein 2.	RB binding protein 7, chromatin remodeling factor.	0.854
AEBP2	eed	ENSPREP00000005569	ENSPREP00000023484	AE binding protein 2.	Embryonic ectoderm development.	0.972
AEBP2	ezh2	ENSPREP00000005569	ENSPREP00000015919	AE binding protein 2.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.898
AEBP2	jarid2	ENSPREP00000005569	ENSPREP00000012408	AE binding protein 2.	Jumonji, AT rich interactive domain 2b.	0.992
AEBP2	kdm6a	ENSPREP00000005569	ENSPREP00000030520	AE binding protein 2.	Lysine (K)-specific demethylase 6A.	0.401
AEBP2	kdm6b	ENSPREP00000005569	ENSPREP00000021959	AE binding protein 2.	Lysine (K)-specific demethylase 6B, a.	0.472
AEBP2	mtf2	ENSPREP00000005569	ENSPREP00000011918	AE binding protein 2.	Metal response element binding transcription factor 2.	0.641
AEBP2	phf1	ENSPREP00000005569	ENSPREP00000026777	AE binding protein 2.	PHD finger protein 1.	0.641
AEBP2	phf19	ENSPREP00000005569	ENSPREP00000023899	AE binding protein 2.	PHD finger protein 19.	0.641
AEBP2	rbbp4	ENSPREP00000005569	ENSPREP00000032501	AE binding protein 2.	Retinoblastoma binding protein 4.	0.938
ENSPREP00000006739	ENSPREP00000018826	ENSPREP00000006739	ENSPREP00000018826	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.707
ENSPREP00000006739	Hcfc2	ENSPREP00000006739	ENSPREP00000023589	Uncharacterized protein.	Host cell factor C2.	0.707
ENSPREP00000006739	KMT2A	ENSPREP00000006739	ENSPREP00000032731	Uncharacterized protein.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	0.523
ENSPREP00000006739	LOC103465550	ENSPREP00000006739	ENSPREP00000032781	Uncharacterized protein.	Host cell factor C1a.	0.707