(26 nodes) Site of double-strand break network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103461057	SET domain and mariner transposase fusion gene. (292 aa)
	WDR70	WD repeat domain 70. (536 aa)
	shld2	Si:ch211-134m17.9. (532 aa)
	iffo1	Intermediate filament family orphan 1b; Belongs to the intermediate filament family. (637 aa)
	ACTR3	Actin related protein 3; Belongs to the actin family. (418 aa)
	LOC103470781	Uncharacterized protein. (224 aa)
	ENSPREP00000002473	Uncharacterized protein. (97 aa)
	LOC103472840	Intermediate filament family orphan 1a; Belongs to the intermediate filament family. (628 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (599 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (593 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1579 aa)
	smarcad1	Uncharacterized protein. (1090 aa)
	ACTR3C	Actin related protein 3C; Belongs to the actin family. (418 aa)
	parp3	Poly [ADP-ribose] polymerase. (522 aa)
	LOC103460840	Uncharacterized protein; Belongs to the actin family. (387 aa)
	ENSPREP00000013033	Uncharacterized protein. (170 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
	LOC103467464	HD domain-containing protein. (433 aa)
	LOC103467467	SAM domain and HD domain 1. (627 aa)
	ENSPREP00000027416	HD domain-containing protein. (178 aa)
	tonsl	Tonsoku-like, DNA repair protein. (1211 aa)
	ENSPREP00000031399	Ring finger protein 168. (425 aa)
	ufl1	UFM1-specific ligase 1. (792 aa)
	aplf	Uncharacterized protein. (302 aa)
	slf1	SMC5-SMC6 complex localization factor 1. (880 aa)
	iffo2	Intermediate filament family orphan 2b; Belongs to the intermediate filament family. (482 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR3	ACTR3C	ENSPREP00000024165	ENSPREP00000015853	Actin related protein 3; Belongs to the actin family.	Actin related protein 3C; Belongs to the actin family.	0.652
ACTR3	ENSPREP00000013033	ENSPREP00000024165	ENSPREP00000013033	Actin related protein 3; Belongs to the actin family.	Uncharacterized protein.	0.653
ACTR3	LOC103460840	ENSPREP00000024165	ENSPREP00000013079	Actin related protein 3; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.652
ACTR3C	ACTR3	ENSPREP00000015853	ENSPREP00000024165	Actin related protein 3C; Belongs to the actin family.	Actin related protein 3; Belongs to the actin family.	0.652
ACTR3C	ENSPREP00000013033	ENSPREP00000015853	ENSPREP00000013033	Actin related protein 3C; Belongs to the actin family.	Uncharacterized protein.	0.655
ACTR3C	LOC103460840	ENSPREP00000015853	ENSPREP00000013079	Actin related protein 3C; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.653
ENSPREP00000002473	rnf8	ENSPREP00000002473	ENSPREP00000012303	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.522
ENSPREP00000002473	tp53bp1	ENSPREP00000002473	ENSPREP00000025854	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.584
ENSPREP00000013033	ACTR3	ENSPREP00000013033	ENSPREP00000024165	Uncharacterized protein.	Actin related protein 3; Belongs to the actin family.	0.653
ENSPREP00000013033	ACTR3C	ENSPREP00000013033	ENSPREP00000015853	Uncharacterized protein.	Actin related protein 3C; Belongs to the actin family.	0.655
ENSPREP00000013033	LOC103460840	ENSPREP00000013033	ENSPREP00000013079	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.653
ENSPREP00000031399	rnf8	ENSPREP00000031399	ENSPREP00000012303	Ring finger protein 168.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.852
ENSPREP00000031399	slf1	ENSPREP00000031399	ENSPREP00000007502	Ring finger protein 168.	SMC5-SMC6 complex localization factor 1.	0.403
ENSPREP00000031399	tp53bp1	ENSPREP00000031399	ENSPREP00000025854	Ring finger protein 168.	Tumor protein p53 binding protein, 1.	0.954
LOC103460840	ACTR3	ENSPREP00000013079	ENSPREP00000024165	Uncharacterized protein; Belongs to the actin family.	Actin related protein 3; Belongs to the actin family.	0.652
LOC103460840	ACTR3C	ENSPREP00000013079	ENSPREP00000015853	Uncharacterized protein; Belongs to the actin family.	Actin related protein 3C; Belongs to the actin family.	0.653
LOC103460840	ENSPREP00000013033	ENSPREP00000013079	ENSPREP00000013033	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.653
LOC103470781	shld2	ENSPREP00000025586	ENSPREP00000018657	Uncharacterized protein.	Si:ch211-134m17.9.	0.939
aplf	parp3	ENSPREP00000006962	ENSPREP00000013935	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.699
aplf	pnkp	ENSPREP00000006962	ENSPREP00000011491	Uncharacterized protein.	Polynucleotide kinase 3'-phosphatase.	0.549