(74 nodes) Membrane raft network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103463294	Plasmalemma vesicle associated protein b. (460 aa)
	LOC103477977	Uncharacterized protein. (439 aa)
	ENSPREP00000018842	Uncharacterized protein. (66 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (345 aa)
	flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	STOML3	Stomatin (EPB72)-like 3a. (267 aa)
	lamtor5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (118 aa)
	LOC103475509	Stomatin (EPB72)-like 3b. (273 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (490 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	LOC103470110	acidPPc domain-containing protein. (279 aa)
	LOC103477907	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (550 aa)
	LOC103476312	Uncharacterized protein. (857 aa)
	LOC103469111	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (367 aa)
	LOC103476339	G_PROTEIN_RECEP_F1_2 domain-containing protein. (484 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)
	lamtor2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (95 aa)
	ENSPREP00000026760	DDE Tnp4 domain-containing protein. (413 aa)
	lamtor1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (160 aa)
	rftn2	Raftlin family member 2. (580 aa)
	ENSPREP00000029319	DDE Tnp4 domain-containing protein. (372 aa)
	LOC103461893	Caveolae associated protein 2a. (470 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	LOC103475233	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	plpp3	Phospholipid phosphatase 3. (313 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (496 aa)
	LOC103473970	Stomatin. (275 aa)
	LOC103474002	Stomatin. (295 aa)
	ENSPREP00000032180	DDE Tnp4 domain-containing protein. (291 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (848 aa)
	mapk7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1073 aa)
	LOC103463553	Phospholipid phosphatase 2b. (289 aa)
	lamtor3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (135 aa)
	LOC103456983	PHB domain-containing protein. (275 aa)
	ENSPREP00000016149	DDE Tnp4 domain-containing protein. (352 aa)
	LOC103480979	Uncharacterized protein. (406 aa)
	plpp2	Phospholipid phosphatase 2a. (287 aa)
	LOC103458453	DDE Tnp4 domain-containing protein. (436 aa)
	mal2	Mal, T cell differentiation protein 2 (gene/pseudogene). (186 aa)
	ENSPREP00000015542	DDE Tnp4 domain-containing protein. (306 aa)
	LOC103456974	Caveolae associated protein 4b. (311 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (388 aa)
	LOC103469402	Caveolae associated protein 1a. (393 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	PTGIS	Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (483 aa)
	adra1d	Adrenoceptor alpha 1D. (514 aa)
	LOC103479149	Uncharacterized protein. (678 aa)
	pag1	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (447 aa)
	LOC103472976	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (350 aa)
	ENSPREP00000011149	Cytochrome P450, family 8, subfamily B, polypeptide 2; Belongs to the cytochrome P450 family. (512 aa)
	bace1	Beta-secretase 1; Belongs to the peptidase A1 family. (506 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (434 aa)
	lamtor4	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (98 aa)
	park7	Parkinson protein 7. (189 aa)
	stoml2	Stomatin (EPB72)-like 2. (351 aa)
	LOC103468776	Phosphatidic acid phosphatase type 2D. (330 aa)
	adra1b	Adrenoceptor alpha 1Bb. (509 aa)
	LOC103477855	Uncharacterized protein. (678 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	LOC103464552	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (184 aa)
	LOC103482185	Caveolae associated protein 1b. (397 aa)
	LOC103478976	acidPPc domain-containing protein. (271 aa)
	LOC103466888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (172 aa)
	PLPP1	Phospholipid phosphatase 1a. (277 aa)
	cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (177 aa)
	LOC103477151	Uncharacterized protein. (158 aa)
	LOC103472214	Raftlin, lipid raft linker 1a. (699 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
	Rangrf	RAN guanine nucleotide release factor. (189 aa)
	LOC103462875	acidPPc domain-containing protein. (328 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
ENSPREP00000021987	Adam17	ENSPREP00000021987	ENSPREP00000021960	ADAM metallopeptidase domain 17b.	Pep_M12B_propep domain-containing protein.	0.932
LOC103456983	lamtor1	ENSPREP00000016950	ENSPREP00000028765	PHB domain-containing protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.433
LOC103458871	Adam17	ENSPREP00000025199	ENSPREP00000021960	ADAM metallopeptidase domain 17a.	Pep_M12B_propep domain-containing protein.	0.902
LOC103461893	cav3	ENSPREP00000030102	ENSPREP00000013872	Caveolae associated protein 2a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.518
LOC103464552	LOC103469402	ENSPREP00000005257	ENSPREP00000014515	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1a.	0.537
LOC103464552	LOC103472976	ENSPREP00000005257	ENSPREP00000011522	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.624
LOC103464552	LOC103482185	ENSPREP00000005257	ENSPREP00000005200	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1b.	0.553
LOC103464552	flot1	ENSPREP00000005257	ENSPREP00000019284	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.619
LOC103465217	LOC103469402	ENSPREP00000013910	ENSPREP00000014515	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1a.	0.645
LOC103465217	LOC103472976	ENSPREP00000013910	ENSPREP00000011522	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.624
LOC103465217	LOC103475233	ENSPREP00000013910	ENSPREP00000030737	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.466
LOC103465217	LOC103482185	ENSPREP00000013910	ENSPREP00000005200	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1b.	0.645
LOC103465217	cav2	ENSPREP00000013910	ENSPREP00000003908	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.925
LOC103465217	cav3	ENSPREP00000013910	ENSPREP00000013872	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.955
LOC103465217	flot1	ENSPREP00000013910	ENSPREP00000019284	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.619
LOC103465217	flot2	ENSPREP00000013910	ENSPREP00000010234	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.466
LOC103466888	LOC103469402	ENSPREP00000004507	ENSPREP00000014515	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1a.	0.537
LOC103466888	LOC103472976	ENSPREP00000004507	ENSPREP00000011522	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.624