(39 nodes) Recycling endosome membrane network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pacsin2	Protein kinase C and casein kinase substrate in neurons 2. (442 aa)
	ENSPREP00000000182	Calponin-homology (CH) domain-containing protein. (109 aa)
	zfyve27	Zinc finger, FYVE domain containing 27. (418 aa)
	LOC103470354	Si:dkey-98f17.5. (425 aa)
	NSG1	Neuronal vesicle trafficking associated 1. (148 aa)
	ABCC4	ATP binding cassette subfamily C member 4. (1194 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1502 aa)
	ENSPREP00000004060	Uncharacterized protein. (158 aa)
	RAP2A	RAP2A, member of RAS oncogene family. (183 aa)
	LOC103458107	EH-domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (546 aa)
	washc1	WAS protein family homolog 1. (474 aa)
	atp13a3	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1264 aa)
	LOC103462136	Secretory carrier-associated membrane protein. (256 aa)
	LOC103476707	Uncharacterized protein. (1315 aa)
	LOC103468194	RAB11 family interacting protein 4 (class II) a. (603 aa)
	LOC103479095	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1204 aa)
	ENSPREP00000012815	RAP2C, member of RAS oncogene family. (142 aa)
	ENSPREP00000013399	Uncharacterized protein. (453 aa)
	LOC103475698	Uncharacterized protein. (183 aa)
	SCAMP1	Secretory carrier-associated membrane protein. (348 aa)
	LOC103457740	EH-domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (345 aa)
	LOC103474464	ATP-binding cassette, sub-family C (CFTR/MRP), member 4. (1322 aa)
	SCAMP2	Secretory carrier-associated membrane protein. (330 aa)
	LOC103470731	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1602 aa)
	cmtm6	MARVEL domain-containing protein. (185 aa)
	smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a. (1641 aa)
	LOC103468256	Uncharacterized protein. (1642 aa)
	LOC103469113	Si:ch211-11k18.4. (438 aa)
	LOC103471421	EH-domain containing 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (533 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2086 aa)
	LAMP5	Lysosomal associated membrane protein family member 5. (269 aa)
	EHD2	EH-domain containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa)
	Rap2b	RAP2B, member of RAS oncogene family. (140 aa)
	LOC103474429	EH-domain containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (545 aa)
	RAB11FIP3	RAB11 family interacting protein 3. (414 aa)
	scamp1	Secretory carrier-associated membrane protein. (395 aa)
	lztr1	Leucine-zipper-like transcription regulator 1. (765 aa)
	arfgap3	ADP-ribosylation factor GTPase activating protein 3. (524 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHD2	ENSPREP00000000182	ENSPREP00000024182	ENSPREP00000000182	EH-domain containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Calponin-homology (CH) domain-containing protein.	0.631
EHD2	LOC103474429	ENSPREP00000024182	ENSPREP00000026039	EH-domain containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	EH-domain containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.901
ENSPREP00000000182	EHD2	ENSPREP00000000182	ENSPREP00000024182	Calponin-homology (CH) domain-containing protein.	EH-domain containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.631
ENSPREP00000000182	LOC103457740	ENSPREP00000000182	ENSPREP00000019063	Calponin-homology (CH) domain-containing protein.	EH-domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.631
ENSPREP00000000182	LOC103458107	ENSPREP00000000182	ENSPREP00000005002	Calponin-homology (CH) domain-containing protein.	EH-domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.631
ENSPREP00000000182	LOC103469113	ENSPREP00000000182	ENSPREP00000022706	Calponin-homology (CH) domain-containing protein.	Si:ch211-11k18.4.	0.462
ENSPREP00000000182	LOC103470354	ENSPREP00000000182	ENSPREP00000000970	Calponin-homology (CH) domain-containing protein.	Si:dkey-98f17.5.	0.462
ENSPREP00000000182	LOC103471421	ENSPREP00000000182	ENSPREP00000023542	Calponin-homology (CH) domain-containing protein.	EH-domain containing 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.631
ENSPREP00000000182	LOC103474429	ENSPREP00000000182	ENSPREP00000026039	Calponin-homology (CH) domain-containing protein.	EH-domain containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.631
ENSPREP00000013399	cmtm6	ENSPREP00000013399	ENSPREP00000021327	Uncharacterized protein.	MARVEL domain-containing protein.	0.483
LOC103457740	ENSPREP00000000182	ENSPREP00000019063	ENSPREP00000000182	EH-domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Calponin-homology (CH) domain-containing protein.	0.631
LOC103458107	ENSPREP00000000182	ENSPREP00000005002	ENSPREP00000000182	EH-domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Calponin-homology (CH) domain-containing protein.	0.631
LOC103469113	ENSPREP00000000182	ENSPREP00000022706	ENSPREP00000000182	Si:ch211-11k18.4.	Calponin-homology (CH) domain-containing protein.	0.462
LOC103470354	ENSPREP00000000182	ENSPREP00000000970	ENSPREP00000000182	Si:dkey-98f17.5.	Calponin-homology (CH) domain-containing protein.	0.462
LOC103471421	ENSPREP00000000182	ENSPREP00000023542	ENSPREP00000000182	EH-domain containing 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Calponin-homology (CH) domain-containing protein.	0.631
LOC103474429	EHD2	ENSPREP00000026039	ENSPREP00000024182	EH-domain containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	EH-domain containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.901
LOC103474429	ENSPREP00000000182	ENSPREP00000026039	ENSPREP00000000182	EH-domain containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Calponin-homology (CH) domain-containing protein.	0.631
LOC103474464	LOC103476707	ENSPREP00000019351	ENSPREP00000009547	ATP-binding cassette, sub-family C (CFTR/MRP), member 4.	Uncharacterized protein.	0.901
LOC103476707	LOC103474464	ENSPREP00000009547	ENSPREP00000019351	Uncharacterized protein.	ATP-binding cassette, sub-family C (CFTR/MRP), member 4.	0.901
cmtm6	ENSPREP00000013399	ENSPREP00000021327	ENSPREP00000013399	MARVEL domain-containing protein.	Uncharacterized protein.	0.483