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VAV1 VAV1 LOC103462114 LOC103462114 plcg2 plcg2 LOC103478918 LOC103478918 SH2B2 SH2B2 chn2 chn2 tns2 tns2 LOC103478934 LOC103478934 fes fes lck lck RIN2 RIN2 LOC103466881 LOC103466881 rin1 rin1 pik3r3 pik3r3 ENSPREP00000004672 ENSPREP00000004672 LOC103482184 LOC103482184 tns4 tns4 socs3 socs3 sla sla LOC103478998 LOC103478998 rasa1 rasa1 syk syk SHF SHF Cish Cish fgr fgr hck hck LOC103465140 LOC103465140 LOC103461355 LOC103461355 TNS3 TNS3 ENSPREP00000008814 ENSPREP00000008814 ENSPREP00000008903 ENSPREP00000008903 ENSPREP00000009358 ENSPREP00000009358 crkl crkl LOC103458742 LOC103458742 tyk2 tyk2 YES1 YES1 ENSPREP00000011332 ENSPREP00000011332 CSK CSK LOC103469946 LOC103469946 jak3 jak3 LOC103468233 LOC103468233 LOC103481609 LOC103481609 LOC103473631 LOC103473631 LOC103460833 LOC103460833 jak2 jak2 LOC103463411 LOC103463411 nck2 nck2 SH2D7 SH2D7 crk crk TNS3-2 TNS3-2 LOC103460130 LOC103460130 LOC103471620 LOC103471620 pik3r2 pik3r2 supt6h supt6h stat3 stat3 LOC103469404 LOC103469404 VAV3 VAV3 LOC103458447 LOC103458447 Socs5 Socs5 SRC SRC LOC103479751 LOC103479751 ptpn6 ptpn6 LOC103467098 LOC103467098 LOC103456982 LOC103456982 dapp1 dapp1 shc2 shc2 LOC103478361 LOC103478361 sh2b1 sh2b1 LOC103463319 LOC103463319 LOC103463556 LOC103463556 SOCS7 SOCS7 sh2d3c sh2d3c btk btk LOC103463527 LOC103463527 grap2 grap2 LOC103479277 LOC103479277 socs6 socs6 abl1 abl1 sh2b3 sh2b3 grb2 grb2 LOC103479892 LOC103479892 LOC103466413 LOC103466413 ENSPREP00000023825 ENSPREP00000023825 LOC103469145 LOC103469145 inpp5d inpp5d ptpn11 ptpn11 ENSPREP00000024937 ENSPREP00000024937 LOC103465382 LOC103465382 LOC103473352 LOC103473352 LOC103478156 LOC103478156 LOC103471376 LOC103471376 shc1 shc1 SHC3 SHC3 LOC103470780 LOC103470780 matk matk LOC103472075 LOC103472075 abl2 abl2 plcg1 plcg1 ENSPREP00000027386 ENSPREP00000027386 blk blk LOC103459817 LOC103459817 inppl1 inppl1 pik3r1 pik3r1 SHE SHE jak1 jak1 itk itk LOC103476509 LOC103476509 LOC103458010 LOC103458010 ENSPREP00000030836 ENSPREP00000030836 LOC103467856 LOC103467856 LOC103470919 LOC103470919 nck1 nck1 socs7 socs7 vav2 vav2 LOC103465566 LOC103465566 LOC103467308 LOC103467308 stat1 stat1 bcar3 bcar3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAV1Vav guanine nucleotide exchange factor 1. (811 aa)
LOC103462114SH2 domain containing 3A. (804 aa)
plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
LOC103478918Tyrosine-protein kinase. (509 aa)
SH2B2SH2B adaptor protein 2. (689 aa)
chn2Chimerin 2. (467 aa)
tns2Tensin 2b. (1542 aa)
LOC103478934SH2 domain-containing protein. (171 aa)
fesTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (824 aa)
lckTyrosine-protein kinase. (500 aa)
RIN2Ras and Rab interactor 2. (993 aa)
LOC103466881Tensin 2a. (1689 aa)
rin1Si:ch211-168d1.3. (789 aa)
pik3r3Uncharacterized protein. (474 aa)
ENSPREP00000004672SH2 domain-containing protein. (141 aa)
LOC103482184Signal transducer and activator of transcription. (784 aa)
tns4SH2 domain-containing protein. (572 aa)
socs3Suppressor of cytokine signaling 3. (208 aa)
slaSrc like adaptor 1a. (278 aa)
LOC103478998Uncharacterized protein. (512 aa)
rasa1RAS p21 protein activator (GTPase activating protein) 1a. (1049 aa)
sykTyrosine-protein kinase. (614 aa)
SHFSrc homology 2 domain containing F. (471 aa)
CishUncharacterized protein. (233 aa)
fgrTyrosine-protein kinase. (534 aa)
hckTyrosine-protein kinase. (500 aa)
LOC103465140Cytokine inducible SH2-containing protein b. (213 aa)
LOC103461355Suppressor of cytokine signaling 3a. (165 aa)
TNS3Tensin 3. (1164 aa)
ENSPREP00000008814SH2 domain-containing protein. (230 aa)
ENSPREP00000008903SH2 domain-containing protein. (223 aa)
ENSPREP00000009358Uncharacterized protein. (158 aa)
crklV-crk avian sarcoma virus CT10 oncogene homolog-like. (310 aa)
LOC103458742Tyrosine-protein kinase. (537 aa)
tyk2Tyrosine-protein kinase. (1153 aa)
YES1Tyrosine-protein kinase. (454 aa)
ENSPREP00000011332SH2 domain-containing protein. (161 aa)
CSKTyrosine-protein kinase. (451 aa)
LOC103469946Tyrosine-protein kinase. (1122 aa)
jak3Tyrosine-protein kinase. (975 aa)
LOC103468233Tyrosine-protein kinase. (606 aa)
LOC103481609Growth factor receptor bound protein 7. (525 aa)
LOC103473631SH2 domain containing 3Ca. (708 aa)
LOC103460833Chimerin 1. (458 aa)
jak2Tyrosine-protein kinase. (1190 aa)
LOC1034634111-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1309 aa)
nck2Cytoplasmic protein. (393 aa)
SH2D7SH2 domain containing 7. (444 aa)
crkCRK proto-oncogene, adaptor protein. (315 aa)
TNS3-2Tensin 3. (1069 aa)
LOC103460130Si:ch211-112g6.4. (367 aa)
LOC103471620Inositol polyphosphate phosphatase-like 1b. (1151 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (701 aa)
supt6hTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1825 aa)
stat3Signal transducer and activator of transcription. (825 aa)
LOC103469404Signal transducer and activator of transcription. (787 aa)
VAV3Vav guanine nucleotide exchange factor 3. (864 aa)
LOC103458447Src homology 2 domain containing transforming protein D, a. (415 aa)
Socs5Suppressor of cytokine signaling 5b. (554 aa)
SRCTyrosine-protein kinase. (569 aa)
LOC103479751Vav 3 guanine nucleotide exchange factor b. (801 aa)
ptpn6Protein tyrosine phosphatase non-receptor type 6. (573 aa)
LOC103467098Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
LOC103456982SH2 domain-containing protein. (202 aa)
dapp1Dual adaptor of phosphotyrosine and 3-phosphoinositides. (296 aa)
shc2SHC (Src homology 2 domain containing) transforming protein 2. (715 aa)
LOC103478361Growth factor receptor-bound protein 10b. (572 aa)
sh2b1SH2B adaptor protein 1. (861 aa)
LOC103463319Uncharacterized protein. (406 aa)
LOC103463556Src homology 2 domain containing transforming protein D, b. (422 aa)
SOCS7Suppressor of cytokine signaling 7. (621 aa)
sh2d3cSH2 domain containing 3Cb. (685 aa)
btkTyrosine-protein kinase. (637 aa)
LOC103463527Hematopoietic SH2 domain containing. (378 aa)
grap2GRB2 related adaptor protein 2a. (428 aa)
LOC103479277Signal transducing adaptor family member 2a. (360 aa)
socs6Suppressor of cytokine signaling 6a. (459 aa)
abl1Tyrosine-protein kinase. (1124 aa)
sh2b3SH2B adaptor protein 3. (710 aa)
grb2Growth factor receptor-bound protein 2b. (217 aa)
LOC103479892Tyrosine-protein kinase. (473 aa)
LOC103466413Tyrosine-protein kinase. (449 aa)
ENSPREP00000023825SH2 domain-containing protein. (93 aa)
LOC103469145GRB2 related adaptor protein a. (214 aa)
inpp5dInositol polyphosphate-5-phosphatase D. (1102 aa)
ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ENSPREP00000024937SH2 domain-containing protein. (152 aa)
LOC103465382Signal transducer and activator of transcription. (801 aa)
LOC103473352Tensin 1. (1228 aa)
LOC103478156Src homology 2 domain containing E. (427 aa)
LOC103471376Uncharacterized protein. (383 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
SHC3SHC adaptor protein 3. (664 aa)
LOC103470780Uncharacterized protein. (705 aa)
matkTyrosine-protein kinase. (467 aa)
LOC103472075Growth factor receptor-bound protein 10a. (590 aa)
abl2Tyrosine-protein kinase. (1187 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1271 aa)
ENSPREP00000027386Suppressor of cytokine signaling 4. (395 aa)
blkTyrosine-protein kinase. (460 aa)
LOC103459817Suppressor of cytokine signaling 2. (196 aa)
inppl1Inositol polyphosphate phosphatase-like 1a. (1248 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
SHESrc homology 2 domain containing E. (477 aa)
jak1Tyrosine-protein kinase. (1174 aa)
itkTyrosine-protein kinase. (617 aa)
LOC103476509Ras and Rab interactor 2. (944 aa)
LOC103458010Tyrosine-protein kinase. (537 aa)
ENSPREP00000030836Tensin 1b. (688 aa)
LOC103467856Tyrosine-protein kinase. (542 aa)
LOC103470919SH2 domain containing 1A duplicate b. (157 aa)
nck1Cytoplasmic protein. (394 aa)
socs7Suppressor of cytokine signaling 7. (806 aa)
vav2Vav 2 guanine nucleotide exchange factor. (793 aa)
LOC103465566Si:ch211-25d12.7. (270 aa)
LOC103467308Signal transducer and activator of transcription. (665 aa)
stat1Signal transducer and activator of transcription. (714 aa)
bcar3BCAR3 adaptor protein, NSP family member. (743 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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