(35 nodes) Guanine-nucleotide dissociation stimulator, CDC24, conserved site network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103473601	BCR activator of RhoGEF and GTPase. (1374 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (811 aa)
	tiam2	T cell lymphoma invasion and metastasis 2a. (1737 aa)
	ENSPREP00000007450	Uncharacterized protein. (511 aa)
	ARHGEF4	Rho guanine nucleotide exchange factor 4. (680 aa)
	ABR	ABR activator of RhoGEF and GTPase. (1099 aa)
	arhgef38	Rho guanine nucleotide exchange factor (GEF) 38. (804 aa)
	rasgrf1	Ras protein specific guanine nucleotide releasing factor 1. (1256 aa)
	LOC103465802	Uncharacterized protein. (567 aa)
	LOC103479717	Mcf.2 cell line derived transforming sequence-like b. (1176 aa)
	LOC103479804	Rho guanine nucleotide exchange factor (GEF) 7a. (757 aa)
	LOC103462737	Uncharacterized protein. (1084 aa)
	mcf2	MCF.2 cell line derived transforming sequence a. (1145 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (864 aa)
	ENSPREP00000015831	Uncharacterized protein. (499 aa)
	mcf2l	Mcf.2 cell line derived transforming sequence-like a. (1028 aa)
	LOC103479751	Vav 3 guanine nucleotide exchange factor b. (801 aa)
	itsn2	Intersectin 2a. (1606 aa)
	LOC103480489	Si:dkey-33c9.6. (676 aa)
	prex1	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1503 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1a. (1672 aa)
	LOC103464037	MCF.2 cell line derived transforming sequence-like 2. (1009 aa)
	ect2	Epithelial cell transforming 2. (1097 aa)
	LOC103474994	T cell lymphoma invasion and metastasis 1b. (1596 aa)
	ENSPREP00000021285	DH domain-containing protein. (251 aa)
	arhgef1	Rho guanine nucleotide exchange factor (GEF) 1b. (1039 aa)
	ENSPREP00000021400	T cell lymphoma invasion and metastasis 2b. (522 aa)
	LOC103461187	Rho guanine nucleotide exchange factor (GEF) 3, like. (443 aa)
	LOC103459721	Neuroepithelial cell transforming 1. (633 aa)
	prex2	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2. (1613 aa)
	LOC103467350	Uncharacterized protein. (690 aa)
	vav2	Vav 2 guanine nucleotide exchange factor. (793 aa)
	Arhgef12	DH domain-containing protein. (250 aa)
	dnmbp	Dynamin binding protein. (1686 aa)
	arhgef3	Rho guanine nucleotide exchange factor (GEF) 3. (642 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF4	ENSPREP00000007450	ENSPREP00000008335	ENSPREP00000007450	Rho guanine nucleotide exchange factor 4.	Uncharacterized protein.	0.487
ARHGEF4	ENSPREP00000015831	ENSPREP00000008335	ENSPREP00000015831	Rho guanine nucleotide exchange factor 4.	Uncharacterized protein.	0.488
ARHGEF4	itsn2	ENSPREP00000008335	ENSPREP00000017512	Rho guanine nucleotide exchange factor 4.	Intersectin 2a.	0.488
Arhgef12	ENSPREP00000007450	ENSPREP00000032828	ENSPREP00000007450	DH domain-containing protein.	Uncharacterized protein.	0.433
Arhgef12	ENSPREP00000015831	ENSPREP00000032828	ENSPREP00000015831	DH domain-containing protein.	Uncharacterized protein.	0.450
Arhgef12	ect2	ENSPREP00000032828	ENSPREP00000019129	DH domain-containing protein.	Epithelial cell transforming 2.	0.529
Arhgef12	itsn2	ENSPREP00000032828	ENSPREP00000017512	DH domain-containing protein.	Intersectin 2a.	0.450
ENSPREP00000007450	ARHGEF4	ENSPREP00000007450	ENSPREP00000008335	Uncharacterized protein.	Rho guanine nucleotide exchange factor 4.	0.487
ENSPREP00000007450	Arhgef12	ENSPREP00000007450	ENSPREP00000032828	Uncharacterized protein.	DH domain-containing protein.	0.433
ENSPREP00000007450	ENSPREP00000015831	ENSPREP00000007450	ENSPREP00000015831	Uncharacterized protein.	Uncharacterized protein.	0.948
ENSPREP00000007450	ENSPREP00000021285	ENSPREP00000007450	ENSPREP00000021285	Uncharacterized protein.	DH domain-containing protein.	0.433
ENSPREP00000007450	ENSPREP00000021400	ENSPREP00000007450	ENSPREP00000021400	Uncharacterized protein.	T cell lymphoma invasion and metastasis 2b.	0.487
ENSPREP00000007450	LOC103474994	ENSPREP00000007450	ENSPREP00000020076	Uncharacterized protein.	T cell lymphoma invasion and metastasis 1b.	0.487
ENSPREP00000007450	LOC103479804	ENSPREP00000007450	ENSPREP00000012426	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 7a.	0.539
ENSPREP00000007450	TIAM1	ENSPREP00000007450	ENSPREP00000018913	Uncharacterized protein.	T cell lymphoma invasion and metastasis 1a.	0.487
ENSPREP00000007450	arhgef1	ENSPREP00000007450	ENSPREP00000021393	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 1b.	0.433
ENSPREP00000007450	arhgef38	ENSPREP00000007450	ENSPREP00000008884	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 38.	0.487
ENSPREP00000007450	dnmbp	ENSPREP00000007450	ENSPREP00000033210	Uncharacterized protein.	Dynamin binding protein.	0.487
ENSPREP00000007450	itsn2	ENSPREP00000007450	ENSPREP00000017512	Uncharacterized protein.	Intersectin 2a.	0.948
ENSPREP00000007450	prex1	ENSPREP00000007450	ENSPREP00000018250	Uncharacterized protein.	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1.	0.487