(107 nodes) Ribonuclease H-like superfamily network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000019998	Exonuclease domain-containing protein. (263 aa)
	ENSPREP00000019958	Integrase catalytic domain-containing protein. (421 aa)
	cnot8	CCR4-NOT transcription complex, subunit 8. (285 aa)
	ENSPREP00000019532	Integrase catalytic domain-containing protein. (386 aa)
	ENSPREP00000019416	Integrase catalytic domain-containing protein. (491 aa)
	ENSPREP00000018784	Uncharacterized protein. (565 aa)
	rnaseh1	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (301 aa)
	ENSPREP00000015395	THAP-type domain-containing protein. (299 aa)
	ago4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (913 aa)
	supt6h	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1825 aa)
	LOC103473053	Uncharacterized protein; Belongs to the argonaute family. (695 aa)
	ENSPREP00000006861	Integrase catalytic domain-containing protein. (432 aa)
	ENSPREP00000007023	Uncharacterized protein. (492 aa)
	ENSPREP00000007190	Uncharacterized protein. (1528 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (2776 aa)
	ENSPREP00000031458	Integrase catalytic domain-containing protein. (346 aa)
	ENSPREP00000031609	Integrase catalytic domain-containing protein. (278 aa)
	ENSPREP00000031897	Uncharacterized protein. (484 aa)
	ENSPREP00000032101	Integrase catalytic domain-containing protein. (345 aa)
	rexo4	REX4 homolog, 3'-5' exonuclease. (413 aa)
	prpf8	Pre-mRNA processing factor 8. (2358 aa)
	ENSPREP00000032628	Integrase catalytic domain-containing protein. (437 aa)
	ENSPREP00000032631	Integrase catalytic domain-containing protein. (715 aa)
	LOC103470954	CCR4-NOT transcription complex, subunit 7. (286 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
	eri1	Exoribonuclease 1. (340 aa)
	LOC103469266	BED-type domain-containing protein. (634 aa)
	ENSPREP00000007481	Uncharacterized protein. (1236 aa)
	ENSPREP00000008411	Uncharacterized protein. (995 aa)
	ENSPREP00000010043	Integrase catalytic domain-containing protein. (687 aa)
	ENSPREP00000010089	Uncharacterized protein. (649 aa)
	ENSPREP00000010152	Integrase catalytic domain-containing protein. (597 aa)
	ENSPREP00000010472	DUF4371 domain-containing protein. (477 aa)
	eri2	Exonuclease domain-containing protein. (255 aa)
	REXO5	RNA exonuclease 5. (806 aa)
	parn	Poly(A)-specific ribonuclease (deadenylation nuclease). (683 aa)
	ENSPREP00000000519	Uncharacterized protein. (1561 aa)
	ENSPREP00000000521	Integrase catalytic domain-containing protein. (275 aa)
	ENSPREP00000000945	Uncharacterized protein. (163 aa)
	pan2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1211 aa)
	LOC103468022	Uncharacterized protein. (916 aa)
	ENSPREP00000001398	Uncharacterized protein. (404 aa)
	ENSPREP00000001432	Uncharacterized protein. (493 aa)
	LOC103463877	Uncharacterized protein. (1129 aa)
	ENSPREP00000002263	Integrase catalytic domain-containing protein. (651 aa)
	ENSPREP00000002539	Integrase catalytic domain-containing protein. (359 aa)
	ENSPREP00000002712	Integrase catalytic domain-containing protein. (640 aa)
	piwil1	Piwi-like RNA-mediated gene silencing 1; Belongs to the argonaute family. (840 aa)
	LOC103472230	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (894 aa)
	esrp2	Epithelial splicing regulatory protein 2. (747 aa)
	ENSPREP00000004299	Uncharacterized protein. (341 aa)
	srbd1	S1 RNA binding domain 1. (983 aa)
	LOC103461223	Integrase catalytic domain-containing protein. (517 aa)
	ENSPREP00000005460	Uncharacterized protein. (1365 aa)
	ENSPREP00000006686	Uncharacterized protein. (1472 aa)
	piwil2	Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (1055 aa)
	exd1	3'-5' exonuclease domain-containing protein. (520 aa)
	ENSPREP00000028300	Uncharacterized protein. (798 aa)
	ENSPREP00000028080	Piwi domain-containing protein. (177 aa)
	isg20l2	Interferon stimulated exonuclease gene 20 like 2. (348 aa)
	polg	Polymerase (DNA directed), gamma. (1253 aa)
	ENSPREP00000027118	Integrase catalytic domain-containing protein. (434 aa)
	ENSPREP00000027013	Integrase catalytic domain-containing protein. (769 aa)
	ENSPREP00000026388	Integrase catalytic domain-containing protein. (351 aa)
	ENSPREP00000026387	Integrase catalytic domain-containing protein. (395 aa)
	rexo2	Small fragment nuclease. (280 aa)
	ENSPREP00000024200	Uncharacterized protein. (687 aa)
	exosc10	Exosome component 10. (892 aa)
	znf618	Zinc finger protein 618. (852 aa)
	ENSPREP00000023243	Integrase catalytic domain-containing protein. (581 aa)
	ENSPREP00000022596	Uncharacterized protein. (387 aa)
	ENSPREP00000009908	Dimer_Tnp_hAT domain-containing protein. (532 aa)
	ENSPREP00000022446	Zgc:113436. (436 aa)
	rnaseh2a	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (296 aa)
	ENSPREP00000021966	Integrase catalytic domain-containing protein. (337 aa)
	exd2	Exonuclease 3'-5' domain containing 2. (644 aa)
	rexo1	REX1, RNA exonuclease 1 homolog. (1238 aa)
	zbed4	Zinc finger, BED-type containing 4. (1243 aa)
	exd3	Exonuclease 3'-5' domain containing 3. (890 aa)
	LOC103460806	Integrase catalytic domain-containing protein. (480 aa)
	ENSPREP00000011673	Uncharacterized protein. (487 aa)
	ENSPREP00000011600	Integrase catalytic domain-containing protein. (500 aa)
	ENSPREP00000011328	Integrase catalytic domain-containing protein. (263 aa)
	ENSPREP00000011313	Integrase catalytic domain-containing protein. (325 aa)
	ENSPREP00000011103	Integrase catalytic domain-containing protein. (357 aa)
	ENSPREP00000011005	Integrase catalytic domain-containing protein. (330 aa)
	LOC103469911	Exonuclease domain-containing protein. (1096 aa)
	ENSPREP00000010829	Integrase catalytic domain-containing protein. (391 aa)
	ENSPREP00000010698	Integrase catalytic domain-containing protein. (428 aa)
	ENSPREP00000010516	Integrase catalytic domain-containing protein. (565 aa)
	pola1	DNA polymerase. (1478 aa)
	LOC103472598	Uncharacterized protein. (871 aa)
	ENSPREP00000020672	Integrase catalytic domain-containing protein. (367 aa)
	ENSPREP00000020640	Integrase catalytic domain-containing protein. (412 aa)
	ENSPREP00000020531	Integrase catalytic domain-containing protein. (379 aa)
	ENSPREP00000020498	Uncharacterized protein. (1314 aa)
	pold1	DNA polymerase. (1102 aa)
	ENSPREP00000020013	Si:ch1073-296i8.2. (215 aa)
	Isg20	Interferon stimulated exonuclease gene. (218 aa)
	ENSPREP00000008880	Uncharacterized protein. (1102 aa)
	ENSPREP00000008956	Uncharacterized protein. (755 aa)
	polq	Polymerase (DNA directed), theta. (2656 aa)
	ENSPREP00000009564	Uncharacterized protein. (719 aa)
	LOC103477773	Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
	ENSPREP00000009715	Dimer_Tnp_hAT domain-containing protein. (569 aa)
	LOC103477771	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (867 aa)
	ENSPREP00000009784	Reverse transcriptase domain-containing protein. (544 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000000521	ENSPREP00000009784	ENSPREP00000000521	ENSPREP00000009784	Integrase catalytic domain-containing protein.	Reverse transcriptase domain-containing protein.	0.506
ENSPREP00000000945	pan2	ENSPREP00000000945	ENSPREP00000001209	Uncharacterized protein.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.549
ENSPREP00000000945	parn	ENSPREP00000000945	ENSPREP00000000165	Uncharacterized protein.	Poly(A)-specific ribonuclease (deadenylation nuclease).	0.549
ENSPREP00000002539	ENSPREP00000009784	ENSPREP00000002539	ENSPREP00000009784	Integrase catalytic domain-containing protein.	Reverse transcriptase domain-containing protein.	0.538
ENSPREP00000004299	ENSPREP00000009784	ENSPREP00000004299	ENSPREP00000009784	Uncharacterized protein.	Reverse transcriptase domain-containing protein.	0.843
ENSPREP00000006686	ENSPREP00000032101	ENSPREP00000006686	ENSPREP00000032101	Uncharacterized protein.	Integrase catalytic domain-containing protein.	0.410
ENSPREP00000006861	ENSPREP00000009784	ENSPREP00000006861	ENSPREP00000009784	Integrase catalytic domain-containing protein.	Reverse transcriptase domain-containing protein.	0.434
ENSPREP00000009784	ENSPREP00000000521	ENSPREP00000009784	ENSPREP00000000521	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.506
ENSPREP00000009784	ENSPREP00000002539	ENSPREP00000009784	ENSPREP00000002539	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.538
ENSPREP00000009784	ENSPREP00000004299	ENSPREP00000009784	ENSPREP00000004299	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.843
ENSPREP00000009784	ENSPREP00000006861	ENSPREP00000009784	ENSPREP00000006861	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.434
ENSPREP00000009784	ENSPREP00000010698	ENSPREP00000009784	ENSPREP00000010698	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.461
ENSPREP00000009784	ENSPREP00000010829	ENSPREP00000009784	ENSPREP00000010829	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.431
ENSPREP00000009784	ENSPREP00000011103	ENSPREP00000009784	ENSPREP00000011103	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.481
ENSPREP00000009784	ENSPREP00000011313	ENSPREP00000009784	ENSPREP00000011313	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.474
ENSPREP00000009784	ENSPREP00000019416	ENSPREP00000009784	ENSPREP00000019416	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.564
ENSPREP00000009784	ENSPREP00000019532	ENSPREP00000009784	ENSPREP00000019532	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.509
ENSPREP00000009784	ENSPREP00000021966	ENSPREP00000009784	ENSPREP00000021966	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.473
ENSPREP00000009784	ENSPREP00000023243	ENSPREP00000009784	ENSPREP00000023243	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.496
ENSPREP00000009784	ENSPREP00000026388	ENSPREP00000009784	ENSPREP00000026388	Reverse transcriptase domain-containing protein.	Integrase catalytic domain-containing protein.	0.460