(13 nodes) ATP-grasp fold, subdomain 1 network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYN3	Synapsin III. (548 aa)
	cps1	Carbamoyl-phosphate synthase 1, mitochondrial. (1505 aa)
	syn1	Synapsin I. (651 aa)
	LOC103467585	Synapsin IIa. (467 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (657 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
	syn2	Uncharacterized protein. (789 aa)
	pc	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1180 aa)
	acacb	Acetyl-CoA carboxylase beta. (2054 aa)
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (714 aa)
	acaca	Acetyl-CoA carboxylase alpha. (2251 aa)
	rimkla	Ribosomal modification protein rimK-like family member A. (401 aa)
	suclg2	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (428 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acaca	acacb	ENSPREP00000001848	ENSPREP00000033271	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.901
acaca	cps1	ENSPREP00000001848	ENSPREP00000018151	Acetyl-CoA carboxylase alpha.	Carbamoyl-phosphate synthase 1, mitochondrial.	0.509
acaca	gart	ENSPREP00000001848	ENSPREP00000009460	Acetyl-CoA carboxylase alpha.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.904
acaca	mccc1	ENSPREP00000001848	ENSPREP00000033480	Acetyl-CoA carboxylase alpha.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.719
acaca	pc	ENSPREP00000001848	ENSPREP00000029584	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.701
acaca	pcca	ENSPREP00000001848	ENSPREP00000011142	Acetyl-CoA carboxylase alpha.	Propionyl-CoA carboxylase subunit alpha.	0.719
acaca	rimkla	ENSPREP00000001848	ENSPREP00000033700	Acetyl-CoA carboxylase alpha.	Ribosomal modification protein rimK-like family member A.	0.444
acaca	suclg2	ENSPREP00000001848	ENSPREP00000027059	Acetyl-CoA carboxylase alpha.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.865
acacb	acaca	ENSPREP00000033271	ENSPREP00000001848	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.901
acacb	cps1	ENSPREP00000033271	ENSPREP00000018151	Acetyl-CoA carboxylase beta.	Carbamoyl-phosphate synthase 1, mitochondrial.	0.509
acacb	gart	ENSPREP00000033271	ENSPREP00000009460	Acetyl-CoA carboxylase beta.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.904
acacb	mccc1	ENSPREP00000033271	ENSPREP00000033480	Acetyl-CoA carboxylase beta.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.719
acacb	pc	ENSPREP00000033271	ENSPREP00000029584	Acetyl-CoA carboxylase beta.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.690
acacb	pcca	ENSPREP00000033271	ENSPREP00000011142	Acetyl-CoA carboxylase beta.	Propionyl-CoA carboxylase subunit alpha.	0.719
acacb	rimkla	ENSPREP00000033271	ENSPREP00000033700	Acetyl-CoA carboxylase beta.	Ribosomal modification protein rimK-like family member A.	0.444
acacb	suclg2	ENSPREP00000033271	ENSPREP00000027059	Acetyl-CoA carboxylase beta.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.865
cps1	acaca	ENSPREP00000018151	ENSPREP00000001848	Carbamoyl-phosphate synthase 1, mitochondrial.	Acetyl-CoA carboxylase alpha.	0.509
cps1	acacb	ENSPREP00000018151	ENSPREP00000033271	Carbamoyl-phosphate synthase 1, mitochondrial.	Acetyl-CoA carboxylase beta.	0.509
cps1	gart	ENSPREP00000018151	ENSPREP00000009460	Carbamoyl-phosphate synthase 1, mitochondrial.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.916
cps1	mccc1	ENSPREP00000018151	ENSPREP00000033480	Carbamoyl-phosphate synthase 1, mitochondrial.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.417