(50 nodes) Rossmann-like alpha/beta/alpha sandwich fold network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTU2	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (364 aa)
	asnsd1	Asparagine synthetase domain containing 1. (592 aa)
	LOC103479060	Zgc:66475. (506 aa)
	lars1	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1184 aa)
	LOC103466705	Si:ch1073-390k14.1. (634 aa)
	eprs1	Glutamyl-prolyl-tRNA synthetase. (1743 aa)
	iars2	Isoleucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1098 aa)
	coasy	CoA synthase. (552 aa)
	papss1	3'-phosphoadenosine 5'-phosphosulfate synthase 1. (657 aa)
	PCYT2	Phosphate cytidylyltransferase 2, ethanolamine. (408 aa)
	pcyt2	Phosphate cytidylyltransferase 2, ethanolamine. (405 aa)
	LOC103459142	Cryptochrome circadian regulator 1a. (623 aa)
	nadsyn1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (663 aa)
	LOC103456565	Cryptochrome DASH. (521 aa)
	LOC103466198	Cryptochrome circadian regulator 1b. (568 aa)
	LOC103461922	Photolyase/cryptochrome alpha/beta domain-containing protein. (652 aa)
	ctu1	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (343 aa)
	LOC103475428	Phosphate cytidylyltransferase 1, choline, beta b. (340 aa)
	wars1	Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (476 aa)
	LOC103466760	Cryptochrome circadian regulator 2. (502 aa)
	wars2	Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (365 aa)
	nmnat2	Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
	yars1	Tyrosine--tRNA ligase. (526 aa)
	cars2	Cysteinyl-tRNA synthetase 2, mitochondrial. (553 aa)
	flad1	Flavin adenine dinucleotide synthetase 1. (560 aa)
	gmps	Guanine monophosphate synthase. (690 aa)
	qars1	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (735 aa)
	nmnat1	Nicotinamide-nucleotide adenylyltransferase. (285 aa)
	ASS1	Argininosuccinate synthase 1. (483 aa)
	LOC103457080	Valyl-tRNA synthetase 2, mitochondrial (putative); Belongs to the class-I aminoacyl-tRNA synthetase family. (1015 aa)
	pcyt1b	Phosphate cytidylyltransferase 1, choline, beta a. (386 aa)
	LOC103479319	Nicotinamide-nucleotide adenylyltransferase. (265 aa)
	LOC103476794	3'-phosphoadenosine 5'-phosphosulfate synthase 2a. (614 aa)
	pcyt1a	Phosphate cytidylyltransferase 1, choline, alpha a. (384 aa)
	ears2	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (539 aa)
	vars2	Valyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1215 aa)
	asns	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	rars1	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (743 aa)
	mars2	Methionyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (593 aa)
	yars2	Tyrosine--tRNA ligase. (480 aa)
	rars2	Arginyl-tRNA synthetase 2, mitochondrial (putative); Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa)
	lars2	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (891 aa)
	LOC103462600	Cryptochrome circadian regulator 5. (521 aa)
	ENSPREP00000012301	tRNA-synt_1e domain-containing protein. (75 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (347 aa)
	mars1	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (912 aa)
	trmu	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase. (416 aa)
	Dph6	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. (252 aa)
	iars1	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1271 aa)
	ENSPREP00000010030	Electron transfer flavoprotein subunit beta. (243 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASS1	asns	ENSPREP00000022473	ENSPREP00000019337	Argininosuccinate synthase 1.	Asparagine synthetase [glutamine-hydrolyzing].	0.957
ASS1	asnsd1	ENSPREP00000022473	ENSPREP00000008975	Argininosuccinate synthase 1.	Asparagine synthetase domain containing 1.	0.490
ASS1	eprs1	ENSPREP00000022473	ENSPREP00000006338	Argininosuccinate synthase 1.	Glutamyl-prolyl-tRNA synthetase.	0.468
ASS1	vars2	ENSPREP00000022473	ENSPREP00000019648	Argininosuccinate synthase 1.	Valyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.440
CTU2	ctu1	ENSPREP00000010239	ENSPREP00000029633	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.813
CTU2	trmu	ENSPREP00000010239	ENSPREP00000011756	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase.	0.531
ENSPREP00000010030	etfa	ENSPREP00000010030	ENSPREP00000012294	Electron transfer flavoprotein subunit beta.	Electron transfer flavoprotein subunit alpha.	0.999
ENSPREP00000010030	flad1	ENSPREP00000010030	ENSPREP00000025453	Electron transfer flavoprotein subunit beta.	Flavin adenine dinucleotide synthetase 1.	0.662
ENSPREP00000012301	LOC103457080	ENSPREP00000012301	ENSPREP00000022249	tRNA-synt_1e domain-containing protein.	Valyl-tRNA synthetase 2, mitochondrial (putative); Belongs to the class-I aminoacyl-tRNA synthetase family.	0.617
ENSPREP00000012301	LOC103476794	ENSPREP00000012301	ENSPREP00000020899	tRNA-synt_1e domain-containing protein.	3'-phosphoadenosine 5'-phosphosulfate synthase 2a.	0.732
ENSPREP00000012301	asns	ENSPREP00000012301	ENSPREP00000019337	tRNA-synt_1e domain-containing protein.	Asparagine synthetase [glutamine-hydrolyzing].	0.402
ENSPREP00000012301	ctu1	ENSPREP00000012301	ENSPREP00000029633	tRNA-synt_1e domain-containing protein.	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.437
ENSPREP00000012301	ears2	ENSPREP00000012301	ENSPREP00000020496	tRNA-synt_1e domain-containing protein.	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.623
ENSPREP00000012301	eprs1	ENSPREP00000012301	ENSPREP00000006338	tRNA-synt_1e domain-containing protein.	Glutamyl-prolyl-tRNA synthetase.	0.805
ENSPREP00000012301	flad1	ENSPREP00000012301	ENSPREP00000025453	tRNA-synt_1e domain-containing protein.	Flavin adenine dinucleotide synthetase 1.	0.513
ENSPREP00000012301	gmps	ENSPREP00000012301	ENSPREP00000024787	tRNA-synt_1e domain-containing protein.	Guanine monophosphate synthase.	0.559
ENSPREP00000012301	iars1	ENSPREP00000012301	ENSPREP00000010345	tRNA-synt_1e domain-containing protein.	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.613
ENSPREP00000012301	iars2	ENSPREP00000012301	ENSPREP00000005588	tRNA-synt_1e domain-containing protein.	Isoleucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.614
ENSPREP00000012301	lars1	ENSPREP00000012301	ENSPREP00000008428	tRNA-synt_1e domain-containing protein.	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.812
ENSPREP00000012301	lars2	ENSPREP00000012301	ENSPREP00000013755	tRNA-synt_1e domain-containing protein.	Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.759