(15 nodes) DHS-like NAD/FAD-binding domain superfamily network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Sirt7	Uncharacterized protein. (134 aa)
	dhps	Deoxyhypusine synthase. (365 aa)
	hacl1	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (568 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	sirt1	Sirtuin 1. (677 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (625 aa)
	LOC103479554	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (315 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (347 aa)
	LOC103462087	Nicotinamide nucleotide transhydrogenase 2. (1014 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	LOC103473658	Nicotinamide nucleotide transhydrogenase. (1096 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (326 aa)
	ENSPREP00000025121	Sirtuin 3. (152 aa)
	LOC103466083	Si:dkey-103i16.6. (445 aa)
	LOC103479463	Sirtuin 6. (339 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000025121	LOC103479554	ENSPREP00000025121	ENSPREP00000008857	Sirtuin 3.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.457
ENSPREP00000025121	Sirt7	ENSPREP00000025121	ENSPREP00000000575	Sirtuin 3.	Uncharacterized protein.	0.637
ENSPREP00000025121	sirt1	ENSPREP00000025121	ENSPREP00000003960	Sirtuin 3.	Sirtuin 1.	0.668
ENSPREP00000025121	sirt4	ENSPREP00000025121	ENSPREP00000003147	Sirtuin 3.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.464
ENSPREP00000025121	sirt5	ENSPREP00000025121	ENSPREP00000014162	Sirtuin 3.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.457
LOC103462087	LOC103466083	ENSPREP00000012612	ENSPREP00000025749	Nicotinamide nucleotide transhydrogenase 2.	Si:dkey-103i16.6.	0.902
LOC103462087	LOC103473658	ENSPREP00000012612	ENSPREP00000014070	Nicotinamide nucleotide transhydrogenase 2.	Nicotinamide nucleotide transhydrogenase.	0.901
LOC103462087	LOC103479463	ENSPREP00000012612	ENSPREP00000026036	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 6.	0.901
LOC103462087	sirt1	ENSPREP00000012612	ENSPREP00000003960	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 1.	0.903
LOC103462087	sirt2	ENSPREP00000012612	ENSPREP00000012959	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.900
LOC103462087	sirt4	ENSPREP00000012612	ENSPREP00000003147	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.900
LOC103462087	sirt5	ENSPREP00000012612	ENSPREP00000014162	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.901
LOC103466083	LOC103462087	ENSPREP00000025749	ENSPREP00000012612	Si:dkey-103i16.6.	Nicotinamide nucleotide transhydrogenase 2.	0.902
LOC103466083	LOC103473658	ENSPREP00000025749	ENSPREP00000014070	Si:dkey-103i16.6.	Nicotinamide nucleotide transhydrogenase.	0.902
LOC103466083	LOC103479463	ENSPREP00000025749	ENSPREP00000026036	Si:dkey-103i16.6.	Sirtuin 6.	0.426
LOC103466083	LOC103479554	ENSPREP00000025749	ENSPREP00000008857	Si:dkey-103i16.6.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.569
LOC103466083	sirt1	ENSPREP00000025749	ENSPREP00000003960	Si:dkey-103i16.6.	Sirtuin 1.	0.654
LOC103466083	sirt4	ENSPREP00000025749	ENSPREP00000003147	Si:dkey-103i16.6.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.550
LOC103466083	sirt5	ENSPREP00000025749	ENSPREP00000014162	Si:dkey-103i16.6.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.566
LOC103473658	LOC103462087	ENSPREP00000014070	ENSPREP00000012612	Nicotinamide nucleotide transhydrogenase.	Nicotinamide nucleotide transhydrogenase 2.	0.901