(72 nodes) FAD/NAD(P)-binding domain superfamily network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103467862	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
	chdh	Choline dehydrogenase. (605 aa)
	aifm3	Apoptosis inducing factor mitochondria associated 3. (584 aa)
	LOC103463767	Dimethylaniline monooxygenase [N-oxide-forming]. (543 aa)
	rnls	Renalase, FAD-dependent amine oxidase. (349 aa)
	LOC103466250	Microtubule associated monooxygenase, calponin and LIM domain containing 2b. (1798 aa)
	LOC103463764	Dimethylaniline monooxygenase [N-oxide-forming]. (552 aa)
	LOC103463766	Dimethylaniline monooxygenase [N-oxide-forming]. (553 aa)
	ENSPREP00000002634	Flavin-containing monooxygenase. (115 aa)
	LOC103459864	Flavin-containing monooxygenase. (447 aa)
	dld	Dihydrolipoyl dehydrogenase. (508 aa)
	kmo	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (480 aa)
	pyroxd1	Pyridine nucleotide-disulphide oxidoreductase domain 1. (500 aa)
	LOC103459897	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (550 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
	pdpr	Pyruvate dehydrogenase phosphatase regulatory subunit. (892 aa)
	smox	Spermine oxidase. (571 aa)
	LOC103480937	Amine oxidase. (541 aa)
	LOC103480925	Amine oxidase. (545 aa)
	LOC103480938	Amino_oxidase domain-containing protein. (564 aa)
	LOC103468165	Uncharacterized protein. (609 aa)
	LOC103475662	Prenylcysteine oxidase 1 like. (283 aa)
	etfdh	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (622 aa)
	sardh	Sarcosine dehydrogenase. (916 aa)
	KDM1B	Lysine demethylase 1B. (579 aa)
	LOC103475640	Apoptosis inducing factor mitochondria associated 5. (547 aa)
	ENSPREP00000013371	Uncharacterized protein. (638 aa)
	RETSAT	Retinol saturase. (610 aa)
	LOC103481656	Si:ch1073-13h15.3. (612 aa)
	pcyox1	Prenylcysteine oxidase 1. (506 aa)
	coq6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (482 aa)
	ENSPREP00000018568	Uncharacterized protein. (419 aa)
	aifm2	Apoptosis inducing factor mitochondria associated 2. (360 aa)
	LOC103460998	Dimethylaniline monooxygenase [N-oxide-forming]. (552 aa)
	LOC108166039	Flavin-containing monooxygenase. (375 aa)
	gsr	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (503 aa)
	sdha	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (663 aa)
	mto1	Mitochondrial tRNA translation optimization 1. (535 aa)
	foxred1	FAD-dependent oxidoreductase domain containing 1. (515 aa)
	dpyd	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
	pipox	Pipecolic acid oxidase. (388 aa)
	foxred2	FAD-dependent oxidoreductase domain containing 2. (681 aa)
	LOC103466044	Si:dkey-234i14.6. (406 aa)
	gpd2	Glycerol-3-phosphate dehydrogenase 2 (mitochondrial). (727 aa)
	sqor	Sulfide quinone oxidoreductase. (439 aa)
	LOC103461168	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa)
	LOC103474367	Amine oxidase. (551 aa)
	LOC103461196	Amine oxidase. (512 aa)
	sqle	Squalene epoxidase a. (561 aa)
	osgin2	Oxidative stress induced growth inhibitor family member 2. (478 aa)
	LOC103459724	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (450 aa)
	LOC103465416	Thioredoxin reductase 3. (600 aa)
	l2hgdh	L-2-hydroxyglutarate dehydrogenase. (447 aa)
	ppox	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (476 aa)
	ENSPREP00000027275	FAD_binding_3 domain-containing protein. (293 aa)
	txnrd2	Thioredoxin reductase 2, tandem duplicate 1. (512 aa)
	dmgdh	Dimethylglycine dehydrogenase. (870 aa)
	fdxr	NADPH:adrenodoxin oxidoreductase, mitochondrial. (462 aa)
	pyroxd2	Pyridine nucleotide-disulphide oxidoreductase domain 2. (567 aa)
	LOC103462025	Zgc:113276. (470 aa)
	LOC103475853	Pyr_redox_2 domain-containing protein. (552 aa)
	maob	Amine oxidase. (566 aa)
	ENSPREP00000030928	FAD_binding_3 domain-containing protein. (278 aa)
	mical3	Microtubule associated monooxygenase, calponin and LIM domain containing 3a. (1895 aa)
	LOC103476962	Uncharacterized protein. (458 aa)
	LOC103476963	Amino_oxidase domain-containing protein. (501 aa)
	LOC103474546	Apoptosis inducing factor mitochondria associated 4. (471 aa)
	ENSPREP00000032699	Amine oxidase. (454 aa)
	LOC103464326	Oxidative stress induced growth inhibitor 1. (519 aa)
	ENSPREP00000034091	Uncharacterized protein. (272 aa)
	LOC103462477	Microtubule associated monooxygenase, calponin and LIM domain containing 2a. (890 aa)
	LOC103475891	Apoptosis inducing factor mitochondrion associated 1. (597 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002634	LOC108166039	ENSPREP00000002634	ENSPREP00000020045	Flavin-containing monooxygenase.	Flavin-containing monooxygenase.	0.950
ENSPREP00000002634	coq6	ENSPREP00000002634	ENSPREP00000015485	Flavin-containing monooxygenase.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.418
ENSPREP00000013371	gpd2	ENSPREP00000013371	ENSPREP00000023257	Uncharacterized protein.	Glycerol-3-phosphate dehydrogenase 2 (mitochondrial).	0.611
ENSPREP00000013371	kmo	ENSPREP00000013371	ENSPREP00000004178	Uncharacterized protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.469
ENSPREP00000032699	LOC103461196	ENSPREP00000032699	ENSPREP00000023801	Amine oxidase.	Amine oxidase.	0.900
ENSPREP00000032699	LOC103474367	ENSPREP00000032699	ENSPREP00000023779	Amine oxidase.	Amine oxidase.	0.900
ENSPREP00000032699	LOC103480925	ENSPREP00000032699	ENSPREP00000008492	Amine oxidase.	Amine oxidase.	0.900
ENSPREP00000032699	LOC103480937	ENSPREP00000032699	ENSPREP00000008480	Amine oxidase.	Amine oxidase.	0.900
ENSPREP00000032699	maob	ENSPREP00000032699	ENSPREP00000030652	Amine oxidase.	Amine oxidase.	0.910
ENSPREP00000034091	mto1	ENSPREP00000034091	ENSPREP00000021113	Uncharacterized protein.	Mitochondrial tRNA translation optimization 1.	0.951
KDM1B	kdm1a	ENSPREP00000012771	ENSPREP00000006670	Lysine demethylase 1B.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.448
LOC103459724	LOC103459897	ENSPREP00000025403	ENSPREP00000005116	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.621
LOC103459864	coq6	ENSPREP00000003154	ENSPREP00000015485	Flavin-containing monooxygenase.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.418
LOC103459897	LOC103459724	ENSPREP00000005116	ENSPREP00000025403	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.621
LOC103459897	LOC103461168	ENSPREP00000005116	ENSPREP00000023328	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.621
LOC103459897	LOC103467862	ENSPREP00000005116	ENSPREP00000030766	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.621
LOC103460998	coq6	ENSPREP00000019622	ENSPREP00000015485	Dimethylaniline monooxygenase [N-oxide-forming].	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.418
LOC103461168	LOC103459897	ENSPREP00000023328	ENSPREP00000005116	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.621
LOC103461196	ENSPREP00000032699	ENSPREP00000023801	ENSPREP00000032699	Amine oxidase.	Amine oxidase.	0.900
LOC103461196	LOC103474367	ENSPREP00000023801	ENSPREP00000023779	Amine oxidase.	Amine oxidase.	0.903