(11 nodes) Insulin-like superfamily network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000030771	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (65 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	LOC103476384	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (79 aa)
	LOC103468255	IlGF domain-containing protein. (140 aa)
	LOC103473640	IlGF domain-containing protein. (179 aa)
	LOC103479157	IlGF domain-containing protein. (90 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	LOC103466958	IlGF domain-containing protein. (196 aa)
	ENSPREP00000006138	IlGF domain-containing protein. (120 aa)
	LOC103469300	Relaxin 3a. (149 aa)
	rln3	Relaxin 3b. (141 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006138	LOC103479157	ENSPREP00000006138	ENSPREP00000012891	IlGF domain-containing protein.	IlGF domain-containing protein.	0.501
ENSPREP00000030771	igf1	ENSPREP00000030771	ENSPREP00000010429	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor 1.	0.471
ENSPREP00000030771	igf2	ENSPREP00000030771	ENSPREP00000029568	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	IlGF domain-containing protein.	0.416
LOC103466958	LOC103479157	ENSPREP00000009138	ENSPREP00000012891	IlGF domain-containing protein.	IlGF domain-containing protein.	0.501
LOC103466958	igf2	ENSPREP00000009138	ENSPREP00000029568	IlGF domain-containing protein.	IlGF domain-containing protein.	0.410
LOC103468255	LOC103469300	ENSPREP00000014447	ENSPREP00000001622	IlGF domain-containing protein.	Relaxin 3a.	0.930
LOC103468255	LOC103479157	ENSPREP00000014447	ENSPREP00000012891	IlGF domain-containing protein.	IlGF domain-containing protein.	0.545
LOC103468255	rln3	ENSPREP00000014447	ENSPREP00000000556	IlGF domain-containing protein.	Relaxin 3b.	0.907
LOC103469300	LOC103468255	ENSPREP00000001622	ENSPREP00000014447	Relaxin 3a.	IlGF domain-containing protein.	0.930
LOC103469300	rln3	ENSPREP00000001622	ENSPREP00000000556	Relaxin 3a.	Relaxin 3b.	0.908
LOC103476384	igf1	ENSPREP00000025882	ENSPREP00000010429	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor 1.	0.471
LOC103476384	igf2	ENSPREP00000025882	ENSPREP00000029568	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	IlGF domain-containing protein.	0.416
LOC103479157	ENSPREP00000006138	ENSPREP00000012891	ENSPREP00000006138	IlGF domain-containing protein.	IlGF domain-containing protein.	0.501
LOC103479157	LOC103466958	ENSPREP00000012891	ENSPREP00000009138	IlGF domain-containing protein.	IlGF domain-containing protein.	0.501
LOC103479157	LOC103468255	ENSPREP00000012891	ENSPREP00000014447	IlGF domain-containing protein.	IlGF domain-containing protein.	0.545
igf1	ENSPREP00000030771	ENSPREP00000010429	ENSPREP00000030771	Insulin-like growth factor 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.471
igf1	LOC103476384	ENSPREP00000010429	ENSPREP00000025882	Insulin-like growth factor 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.471
igf1	igf2	ENSPREP00000010429	ENSPREP00000029568	Insulin-like growth factor 1.	IlGF domain-containing protein.	0.770
igf2	ENSPREP00000030771	ENSPREP00000029568	ENSPREP00000030771	IlGF domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.416
igf2	LOC103466958	ENSPREP00000029568	ENSPREP00000009138	IlGF domain-containing protein.	IlGF domain-containing protein.	0.410