(58 nodes) IRS-mediated signalling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	klb	Klotho beta. (1050 aa)
	pde3b	Phosphodiesterase. (1096 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (266 aa)
	irs2	Insulin receptor substrate 2b. (1115 aa)
	Pik3ca	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (306 aa)
	LOC103470957	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (538 aa)
	LCT	Lactase. (1583 aa)
	ENSPREP00000025004	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (378 aa)
	LOC103478140	Thioesterase superfamily member 4. (254 aa)
	ENSPREP00000023045	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (582 aa)
	ENSPREP00000022877	Uncharacterized protein. (62 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	gab2	GRB2-associated binding protein 2. (676 aa)
	LOC103464789	Tribbles pseudokinase 3. (351 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103473157	Fibroblast growth factor receptor. (756 aa)
	ENSPREP00000018426	Uncharacterized protein. (108 aa)
	LOC103480707	PH domain-containing protein. (763 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	kl	Klotho. (969 aa)
	lctl	Lactase-like b; Belongs to the glycosyl hydrolase 1 family. (606 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	LOC103473660	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (503 aa)
	LOC103477293	Fibroblast growth factor receptor. (676 aa)
	ENSPREP00000013954	Uncharacterized protein. (326 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	LOC103475907	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	ENSPREP00000004603	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (521 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	LOC103474789	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	fgfr4	Fibroblast growth factor receptor 4. (942 aa)
	LOC103458160	Fibroblast growth factor receptor. (814 aa)
	LOC103479066	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103471871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (173 aa)
	LOC103476518	Insulin receptor substrate 2a. (1060 aa)
	LOC103475676	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	LOC103460817	Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (446 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
	gab1	GRB2-associated binding protein 1. (756 aa)
	LOC103469672	Fibroblast growth factor receptor. (831 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	ENSPREP00000001733	Uncharacterized protein. (134 aa)
	LOC103471324	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004603	ENSPREP00000010497	ENSPREP00000004603	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.447
ENSPREP00000004603	ENSPREP00000013954	ENSPREP00000004603	ENSPREP00000013954	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.455
ENSPREP00000004603	LOC103458160	ENSPREP00000004603	ENSPREP00000009232	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.413
ENSPREP00000004603	LOC103469672	ENSPREP00000004603	ENSPREP00000001007	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.403
ENSPREP00000004603	LOC103473660	ENSPREP00000004603	ENSPREP00000014108	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
ENSPREP00000004603	LOC103476521	ENSPREP00000004603	ENSPREP00000029747	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.511
ENSPREP00000004603	LOC103477293	ENSPREP00000004603	ENSPREP00000014037	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.455
ENSPREP00000004603	fgf10	ENSPREP00000004603	ENSPREP00000014875	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
ENSPREP00000004603	fgf19	ENSPREP00000004603	ENSPREP00000002527	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.569
ENSPREP00000004603	fgf22	ENSPREP00000004603	ENSPREP00000011331	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
ENSPREP00000004603	fgf23	ENSPREP00000004603	ENSPREP00000033759	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.569
ENSPREP00000004603	fgf3	ENSPREP00000004603	ENSPREP00000002583	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.438
ENSPREP00000004603	fgf5	ENSPREP00000004603	ENSPREP00000004455	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.465
ENSPREP00000004603	fgf7	ENSPREP00000004603	ENSPREP00000012669	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.416
ENSPREP00000004603	fgfr4	ENSPREP00000004603	ENSPREP00000008616	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 4.	0.413
ENSPREP00000004603	grb2	ENSPREP00000004603	ENSPREP00000022510	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.488
ENSPREP00000006768	ENSPREP00000013954	ENSPREP00000006768	ENSPREP00000013954	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein.	0.810
ENSPREP00000006768	ENSPREP00000023045	ENSPREP00000006768	ENSPREP00000023045	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	0.411
ENSPREP00000006768	ENSPREP00000025004	ENSPREP00000006768	ENSPREP00000025004	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	0.411
ENSPREP00000006768	LCT	ENSPREP00000006768	ENSPREP00000025166	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Lactase.	0.411