(62 nodes) Signaling by SCF-KIT network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (848 aa)
	stat1	Signal transducer and activator of transcription. (714 aa)
	Pik3ca	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (306 aa)
	MMP9	Matrix metallopeptidase 9. (689 aa)
	LOC103472075	Growth factor receptor-bound protein 10a. (590 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC103470780	Uncharacterized protein. (705 aa)
	ENSPREP00000024995	Protein kinase domain-containing protein. (161 aa)
	ENSPREP00000024937	SH2 domain-containing protein. (152 aa)
	LOC108165961	F-BAR domain-containing protein. (174 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	LOC103469145	GRB2 related adaptor protein a. (214 aa)
	LOC103479892	Tyrosine-protein kinase. (473 aa)
	LOC103476312	Uncharacterized protein. (857 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	LOC103477907	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (550 aa)
	gab2	GRB2-associated binding protein 2. (676 aa)
	LOC103460710	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
	LOC103460719	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1236 aa)
	ENSPREP00000021359	Matrix metallopeptidase 9. (634 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	LOC103471974	Protein tyrosine phosphatase receptor type Ua. (1454 aa)
	LOC103467157	Matrix metallopeptidase 9. (670 aa)
	LOC103469088	Zgc:55558. (191 aa)
	LOC103467158	Uncharacterized protein. (664 aa)
	grap2	GRB2 related adaptor protein 2a. (428 aa)
	LOC103468941	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (956 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1175 aa)
	LOC103463319	Uncharacterized protein. (406 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (912 aa)
	LOC103478361	Growth factor receptor-bound protein 10b. (572 aa)
	LOC103467098	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (573 aa)
	SRC	Tyrosine-protein kinase. (569 aa)
	LOC103469404	Signal transducer and activator of transcription. (787 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (701 aa)
	jak2	Tyrosine-protein kinase. (1190 aa)
	LOC103481609	Growth factor receptor bound protein 7. (525 aa)
	LOC103469946	Tyrosine-protein kinase. (1122 aa)
	LOC103478458	Protein tyrosine phosphatase receptor type Ub. (1448 aa)
	ENSPREP00000011332	SH2 domain-containing protein. (161 aa)
	Grb14	Uncharacterized protein. (199 aa)
	YES1	Tyrosine-protein kinase. (454 aa)
	LOC103458742	Tyrosine-protein kinase. (537 aa)
	ENSPREP00000009358	Uncharacterized protein. (158 aa)
	LOC103479066	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ENSPREP00000009325	GRB2 related adaptor protein b. (229 aa)
	LOC103478998	Uncharacterized protein. (512 aa)
	LOC103482184	Signal transducer and activator of transcription. (784 aa)
	pik3r3	Uncharacterized protein. (474 aa)
	Kitlg	Kit ligand a. (201 aa)
	lck	Tyrosine-protein kinase. (500 aa)
	LOC103475907	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	fes	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (824 aa)
	LOC103478918	Tyrosine-protein kinase. (509 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	kit	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	LOC103458010	Tyrosine-protein kinase. (537 aa)
	LOC103467856	Tyrosine-protein kinase. (542 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	Kitlg	ENSPREP00000017340	ENSPREP00000004205	Cold shock domain containing E1, RNA-binding.	Kit ligand a.	0.442
CSDE1	LOC103458010	ENSPREP00000017340	ENSPREP00000030555	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.431
CSDE1	LOC103458742	ENSPREP00000017340	ENSPREP00000009827	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.431
CSDE1	LOC103467098	ENSPREP00000017340	ENSPREP00000016883	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.468
CSDE1	LOC103467856	ENSPREP00000017340	ENSPREP00000031006	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	LOC103470780	ENSPREP00000017340	ENSPREP00000025571	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.418
CSDE1	LOC103475907	ENSPREP00000017340	ENSPREP00000003309	Cold shock domain containing E1, RNA-binding.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.524
CSDE1	LOC103478918	ENSPREP00000017340	ENSPREP00000001386	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	LOC103479066	ENSPREP00000017340	ENSPREP00000009342	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.524
CSDE1	LOC103479892	ENSPREP00000017340	ENSPREP00000022831	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	Pik3ca	ENSPREP00000017340	ENSPREP00000033418	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.524
CSDE1	SRC	ENSPREP00000017340	ENSPREP00000016288	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	YES1	ENSPREP00000017340	ENSPREP00000011214	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	grb2	ENSPREP00000017340	ENSPREP00000022510	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.667
CSDE1	lck	ENSPREP00000017340	ENSPREP00000003459	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	pik3r1	ENSPREP00000017340	ENSPREP00000029108	Cold shock domain containing E1, RNA-binding.	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	0.418
CSDE1	pik3r2	ENSPREP00000017340	ENSPREP00000014262	Cold shock domain containing E1, RNA-binding.	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	0.418
CSDE1	pik3r3	ENSPREP00000017340	ENSPREP00000004356	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.418
CSDE1	ptpn11	ENSPREP00000017340	ENSPREP00000024560	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.468
CSDE1	ptpn6	ENSPREP00000017340	ENSPREP00000016776	Cold shock domain containing E1, RNA-binding.	Protein tyrosine phosphatase non-receptor type 6.	0.468