(19 nodes) Regulation of KIT signaling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kit	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
	LOC103478918	Tyrosine-protein kinase. (509 aa)
	lck	Tyrosine-protein kinase. (500 aa)
	Kitlg	Kit ligand a. (201 aa)
	LOC103458742	Tyrosine-protein kinase. (537 aa)
	YES1	Tyrosine-protein kinase. (454 aa)
	SRC	Tyrosine-protein kinase. (569 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (573 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1175 aa)
	LOC103468941	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (956 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1236 aa)
	LOC103477907	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (550 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	LOC103476312	Uncharacterized protein. (857 aa)
	LOC103479892	Tyrosine-protein kinase. (473 aa)
	LOC103458010	Tyrosine-protein kinase. (537 aa)
	LOC103467856	Tyrosine-protein kinase. (542 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (848 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kitlg	LOC103467856	ENSPREP00000004205	ENSPREP00000031006	Kit ligand a.	Tyrosine-protein kinase.	0.408
Kitlg	LOC103468941	ENSPREP00000004205	ENSPREP00000018433	Kit ligand a.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.992
Kitlg	LOC103478918	ENSPREP00000004205	ENSPREP00000001386	Kit ligand a.	Tyrosine-protein kinase.	0.408
Kitlg	LOC103479892	ENSPREP00000004205	ENSPREP00000022831	Kit ligand a.	Tyrosine-protein kinase.	0.408
Kitlg	SRC	ENSPREP00000004205	ENSPREP00000016288	Kit ligand a.	Tyrosine-protein kinase.	0.408
Kitlg	YES1	ENSPREP00000004205	ENSPREP00000011214	Kit ligand a.	Tyrosine-protein kinase.	0.408
Kitlg	grb2	ENSPREP00000004205	ENSPREP00000022510	Kit ligand a.	Growth factor receptor-bound protein 2b.	0.541
Kitlg	kit	ENSPREP00000004205	ENSPREP00000029034	Kit ligand a.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.992
Kitlg	lck	ENSPREP00000004205	ENSPREP00000003459	Kit ligand a.	Tyrosine-protein kinase.	0.408
Kitlg	ptpn6	ENSPREP00000004205	ENSPREP00000016776	Kit ligand a.	Protein tyrosine phosphatase non-receptor type 6.	0.526
Kitlg	sh2b3	ENSPREP00000004205	ENSPREP00000021263	Kit ligand a.	SH2B adaptor protein 3.	0.666
LOC103458010	LOC103467856	ENSPREP00000030555	ENSPREP00000031006	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.438
LOC103458010	LOC103476312	ENSPREP00000030555	ENSPREP00000022529	Tyrosine-protein kinase.	Uncharacterized protein.	0.601
LOC103458010	LOC103477907	ENSPREP00000030555	ENSPREP00000022350	Tyrosine-protein kinase.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.601
LOC103458010	LOC103478918	ENSPREP00000030555	ENSPREP00000001386	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.443
LOC103458010	LOC103479892	ENSPREP00000030555	ENSPREP00000022831	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.438
LOC103458010	SRC	ENSPREP00000030555	ENSPREP00000016288	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.437
LOC103458010	YES1	ENSPREP00000030555	ENSPREP00000011214	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.434
LOC103458010	cbl	ENSPREP00000030555	ENSPREP00000032775	Tyrosine-protein kinase.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.601
LOC103458010	grb2	ENSPREP00000030555	ENSPREP00000022510	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2b.	0.612