(16 nodes) Methylation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	as3mt	Arsenite methyltransferase. (388 aa)
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1275 aa)
	mat2b	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (325 aa)
	n6amt1	N-6 adenine-specific DNA methyltransferase 1. (218 aa)
	LOC103462617	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (589 aa)
	LOC103470577	Cytochrome P450, family 1, subfamily D, polypeptide 1; Belongs to the cytochrome P450 family. (535 aa)
	tpmt	Thiopurine S-methyltransferase, tandem duplicate 1. (234 aa)
	LOC103473691	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
	mtrr	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (713 aa)
	trmt112	tRNA methyltransferase subunit 11-2. (123 aa)
	LOC103473263	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (390 aa)
	LOC103476873	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
	ahcy	Adenosylhomocysteinase. (358 aa)
	LOC103470277	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (362 aa)
	comt	Catechol-O-methyltransferase b. (265 aa)
	LOC103474544	Zgc:153372. (364 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103462617	as3mt	ENSPREP00000012206	ENSPREP00000000629	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	Arsenite methyltransferase.	0.481
LOC103462617	comt	ENSPREP00000012206	ENSPREP00000032086	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	Catechol-O-methyltransferase b.	0.928
LOC103470277	ahcy	ENSPREP00000031739	ENSPREP00000030722	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Adenosylhomocysteinase.	0.683
LOC103470277	comt	ENSPREP00000031739	ENSPREP00000032086	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol-O-methyltransferase b.	0.491
LOC103470277	mat2b	ENSPREP00000031739	ENSPREP00000006040	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.940
LOC103470277	mtr	ENSPREP00000031739	ENSPREP00000003676	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.951
LOC103473263	ahcy	ENSPREP00000026720	ENSPREP00000030722	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Adenosylhomocysteinase.	0.695
LOC103473263	comt	ENSPREP00000026720	ENSPREP00000032086	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol-O-methyltransferase b.	0.491
LOC103473263	mat2b	ENSPREP00000026720	ENSPREP00000006040	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.878
LOC103473263	mtr	ENSPREP00000026720	ENSPREP00000003676	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.951
LOC103473691	ahcy	ENSPREP00000015701	ENSPREP00000030722	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Adenosylhomocysteinase.	0.695
LOC103473691	comt	ENSPREP00000015701	ENSPREP00000032086	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol-O-methyltransferase b.	0.491
LOC103473691	mat2b	ENSPREP00000015701	ENSPREP00000006040	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.878
LOC103473691	mtr	ENSPREP00000015701	ENSPREP00000003676	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.951
LOC103474544	mat2b	ENSPREP00000032397	ENSPREP00000006040	Zgc:153372.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.444
LOC103474544	trmt112	ENSPREP00000032397	ENSPREP00000022591	Zgc:153372.	tRNA methyltransferase subunit 11-2.	0.602
LOC103476873	ahcy	ENSPREP00000027034	ENSPREP00000030722	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Adenosylhomocysteinase.	0.623
LOC103476873	comt	ENSPREP00000027034	ENSPREP00000032086	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol-O-methyltransferase b.	0.491
LOC103476873	mat2b	ENSPREP00000027034	ENSPREP00000006040	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.895
LOC103476873	mtr	ENSPREP00000027034	ENSPREP00000003676	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.951