(53 nodes) Gamma carboxylation, hypusine formation and arylsulfatase activation network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	arsg	Arylsulfatase G. (554 aa)
	dohh	Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (350 aa)
	gas6	Uncharacterized protein. (650 aa)
	pros1	Protein S. (675 aa)
	LOC103480086	Arylsulfatase family, member J. (601 aa)
	proc	Uncharacterized protein. (484 aa)
	LOC103457832	Coagulation factor VII, like. (431 aa)
	LOC103457846	Coagulation factor VII. (451 aa)
	ENSPREP00000033287	Coagulation factor VIIi; Belongs to the peptidase S1 family. (207 aa)
	LOC103457956	Coagulation factor X. (511 aa)
	EIF5AL1	Eukaryotic translation initiation factor 5A. (155 aa)
	ENSPREP00000011001	Coagulation factor IXb. (459 aa)
	eef2	Tr-type G domain-containing protein. (858 aa)
	LOC103475655	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (369 aa)
	icmt	Protein-S-isoprenylcysteine O-methyltransferase. (291 aa)
	dph2	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (490 aa)
	sumf2	Sulfatase modifying factor 2. (323 aa)
	f9	Coagulation factor IXa. (526 aa)
	dph1	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (432 aa)
	ggcx	Gamma-glutamyl carboxylase. (767 aa)
	LOC103461638	Arylsulfatase H. (591 aa)
	eif5a2	eIF-5a domain-containing protein. (187 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	LOC103458414	Eukaryotic translation initiation factor 5A. (110 aa)
	LOC103458413	Eukaryotic translation initiation factor 5A-1-like. (110 aa)
	LOC103468683	Gla domain-containing protein. (191 aa)
	Dph6	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. (252 aa)
	dnajc24	Uncharacterized protein. (171 aa)
	LOC103468804	Fructosamine 3 kinase related protein; Belongs to the fructosamine kinase family. (287 aa)
	arsk	Arylsulfatase family, member K. (526 aa)
	dhps	Deoxyhypusine synthase. (365 aa)
	dph5	Diphthamide biosynthesis 5. (289 aa)
	LOC103462559	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (807 aa)
	LOC103469202	Protein Z, vitamin K-dependent plasma glycoprotein a; Belongs to the peptidase S1 family. (507 aa)
	LOC103469793	SEC14-like lipid binding 8. (410 aa)
	ENSPREP00000003844	Sulfatase domain-containing protein. (130 aa)
	ENSPREP00000003856	Arylsulfatase family, member Ia. (426 aa)
	LOC103476426	Si:dkey-174i8.1. (528 aa)
	LOC103463598	SEC14 like lipid binding 1. (736 aa)
	LOC103460587	Uncharacterized protein. (448 aa)
	LOC103456765	Diphthamide biosynthesis 3. (83 aa)
	dph7	Diphthamide biosynthesis 7. (442 aa)
	arsa	Arylsulfatase A. (499 aa)
	sumf1	Sulfatase modifying factor 1. (355 aa)
	LOC103473217	SEC14-like lipid binding 7. (404 aa)
	tpst1	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (380 aa)
	ENSPREP00000023558	PRELI/MSF1 domain-containing protein. (221 aa)
	bglap	Gla domain-containing protein. (90 aa)
	LOC103479455	Eukaryotic translation elongation factor 2b. (858 aa)
	sts	Steroid sulfatase (microsomal), isozyme S. (574 aa)
	furin	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (848 aa)
	ARSB	Arylsulfatase B. (523 aa)
	LOC103479474	Sulfatase domain-containing protein. (744 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSB	LOC103461638	ENSPREP00000028183	ENSPREP00000015987	Arylsulfatase B.	Arylsulfatase H.	0.527
ARSB	arsa	ENSPREP00000028183	ENSPREP00000022154	Arylsulfatase B.	Arylsulfatase A.	0.957
ARSB	arsg	ENSPREP00000028183	ENSPREP00000029063	Arylsulfatase B.	Arylsulfatase G.	0.958
ARSB	arsk	ENSPREP00000028183	ENSPREP00000007874	Arylsulfatase B.	Arylsulfatase family, member K.	0.647
ARSB	sts	ENSPREP00000028183	ENSPREP00000026613	Arylsulfatase B.	Steroid sulfatase (microsomal), isozyme S.	0.529
ARSB	sumf1	ENSPREP00000028183	ENSPREP00000022816	Arylsulfatase B.	Sulfatase modifying factor 1.	0.696
ARSB	sumf2	ENSPREP00000028183	ENSPREP00000013517	Arylsulfatase B.	Sulfatase modifying factor 2.	0.630
Dph6	LOC103456765	ENSPREP00000010654	ENSPREP00000019764	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	Diphthamide biosynthesis 3.	0.649
Dph6	LOC103479455	ENSPREP00000010654	ENSPREP00000026101	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	Eukaryotic translation elongation factor 2b.	0.794
Dph6	dnajc24	ENSPREP00000010654	ENSPREP00000010466	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	Uncharacterized protein.	0.476
Dph6	dph1	ENSPREP00000010654	ENSPREP00000015308	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	0.549
Dph6	dph2	ENSPREP00000010654	ENSPREP00000013509	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.	0.549
Dph6	dph5	ENSPREP00000010654	ENSPREP00000001713	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	Diphthamide biosynthesis 5.	0.950
Dph6	dph7	ENSPREP00000010654	ENSPREP00000020454	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	Diphthamide biosynthesis 7.	0.650
Dph6	eef2	ENSPREP00000010654	ENSPREP00000012263	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.	Tr-type G domain-containing protein.	0.794
EIF5AL1	LOC103479455	ENSPREP00000019744	ENSPREP00000026101	Eukaryotic translation initiation factor 5A.	Eukaryotic translation elongation factor 2b.	0.818
EIF5AL1	dhps	ENSPREP00000019744	ENSPREP00000001392	Eukaryotic translation initiation factor 5A.	Deoxyhypusine synthase.	0.929
EIF5AL1	dohh	ENSPREP00000019744	ENSPREP00000030653	Eukaryotic translation initiation factor 5A.	Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family.	0.872
EIF5AL1	eef2	ENSPREP00000019744	ENSPREP00000012263	Eukaryotic translation initiation factor 5A.	Tr-type G domain-containing protein.	0.818
ENSPREP00000003844	ENSPREP00000003856	ENSPREP00000003844	ENSPREP00000003856	Sulfatase domain-containing protein.	Arylsulfatase family, member Ia.	0.749