(8 nodes) Trafficking and processing of endosomal TLR network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000002598	Uncharacterized protein. (117 aa)
	unc93b1	Unc-93 homolog B1, TLR signaling regulator. (622 aa)
	ctsb	Cathepsin Bb; Belongs to the peptidase C1 family. (324 aa)
	LOC103480678	Canopy FGF signaling regulator 3. (282 aa)
	tsku	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (348 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (721 aa)
	LOC103459167	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1052 aa)
	ENSPREP00000002617	Uncharacterized protein. (98 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002598	LOC103480678	ENSPREP00000002598	ENSPREP00000018394	Uncharacterized protein.	Canopy FGF signaling regulator 3.	0.569
ENSPREP00000002598	hsp90b1	ENSPREP00000002598	ENSPREP00000005847	Uncharacterized protein.	Heat shock protein 90, beta (grp94), member 1.	0.574
ENSPREP00000002598	unc93b1	ENSPREP00000002598	ENSPREP00000001727	Uncharacterized protein.	Unc-93 homolog B1, TLR signaling regulator.	0.858
ENSPREP00000002617	LOC103480678	ENSPREP00000002617	ENSPREP00000018394	Uncharacterized protein.	Canopy FGF signaling regulator 3.	0.569
ENSPREP00000002617	hsp90b1	ENSPREP00000002617	ENSPREP00000005847	Uncharacterized protein.	Heat shock protein 90, beta (grp94), member 1.	0.574
ENSPREP00000002617	unc93b1	ENSPREP00000002617	ENSPREP00000001727	Uncharacterized protein.	Unc-93 homolog B1, TLR signaling regulator.	0.858
LOC103459167	LOC103480678	ENSPREP00000002624	ENSPREP00000018394	Toll-like receptor 7; Belongs to the Toll-like receptor family.	Canopy FGF signaling regulator 3.	0.569
LOC103459167	hsp90b1	ENSPREP00000002624	ENSPREP00000005847	Toll-like receptor 7; Belongs to the Toll-like receptor family.	Heat shock protein 90, beta (grp94), member 1.	0.574
LOC103459167	unc93b1	ENSPREP00000002624	ENSPREP00000001727	Toll-like receptor 7; Belongs to the Toll-like receptor family.	Unc-93 homolog B1, TLR signaling regulator.	0.858
LOC103480678	ENSPREP00000002598	ENSPREP00000018394	ENSPREP00000002598	Canopy FGF signaling regulator 3.	Uncharacterized protein.	0.569
LOC103480678	ENSPREP00000002617	ENSPREP00000018394	ENSPREP00000002617	Canopy FGF signaling regulator 3.	Uncharacterized protein.	0.569
LOC103480678	LOC103459167	ENSPREP00000018394	ENSPREP00000002624	Canopy FGF signaling regulator 3.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.569
LOC103480678	hsp90b1	ENSPREP00000018394	ENSPREP00000005847	Canopy FGF signaling regulator 3.	Heat shock protein 90, beta (grp94), member 1.	0.809
LOC103480678	unc93b1	ENSPREP00000018394	ENSPREP00000001727	Canopy FGF signaling regulator 3.	Unc-93 homolog B1, TLR signaling regulator.	0.737
hsp90b1	ENSPREP00000002598	ENSPREP00000005847	ENSPREP00000002598	Heat shock protein 90, beta (grp94), member 1.	Uncharacterized protein.	0.574
hsp90b1	ENSPREP00000002617	ENSPREP00000005847	ENSPREP00000002617	Heat shock protein 90, beta (grp94), member 1.	Uncharacterized protein.	0.574
hsp90b1	LOC103459167	ENSPREP00000005847	ENSPREP00000002624	Heat shock protein 90, beta (grp94), member 1.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.574
hsp90b1	LOC103480678	ENSPREP00000005847	ENSPREP00000018394	Heat shock protein 90, beta (grp94), member 1.	Canopy FGF signaling regulator 3.	0.809
hsp90b1	unc93b1	ENSPREP00000005847	ENSPREP00000001727	Heat shock protein 90, beta (grp94), member 1.	Unc-93 homolog B1, TLR signaling regulator.	0.650
tsku	unc93b1	ENSPREP00000007901	ENSPREP00000001727	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis).	Unc-93 homolog B1, TLR signaling regulator.	0.423