(40 nodes) Activation of ATR in response to replication stress network (Poecilia reticulata)

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second shell of interactors

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	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (629 aa)
	LOC103476593	Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (792 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	rpa2	Replication protein A2. (256 aa)
	CDC25B	Cell division cycle 25B. (383 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	cdc7	Cell division cycle 7 homolog (S. cerevisiae). (610 aa)
	mcm4	DNA helicase; Belongs to the MCM family. (880 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
	CLSPN	Claspin. (1239 aa)
	LOC103474198	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (245 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	rad17	RAD17 checkpoint clamp loader component. (705 aa)
	LOC103475329	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
	cdc45	CDC45 cell division cycle 45 homolog (S. cerevisiae). (573 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	rpa3	Replication protein A3. (122 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (104 aa)
	mcm7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (541 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC103475008	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (553 aa)
	atrip	Uncharacterized protein. (763 aa)
	Mcm5	Uncharacterized protein. (58 aa)
	mcm10	Minichromosome maintenance 10 replication initiation factor. (873 aa)
	rad9b	RAD9 checkpoint clamp component B. (442 aa)
	dbf4	DBF4 zinc finger. (593 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
	mcm3	DNA helicase; Belongs to the MCM family. (814 aa)
	orc3	Origin recognition complex, subunit 3. (723 aa)
	mcm6	DNA helicase; Belongs to the MCM family. (825 aa)
	orc2	Origin recognition complex, subunit 2. (578 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (586 aa)
	orc4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
	orc5	Origin recognition complex, subunit 5. (411 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (887 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25B	MCM7	ENSPREP00000010131	ENSPREP00000020776	Cell division cycle 25B.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.421
CDC25B	Mcm5	ENSPREP00000010131	ENSPREP00000022230	Cell division cycle 25B.	Uncharacterized protein.	0.406
CDC25B	atr	ENSPREP00000010131	ENSPREP00000016955	Cell division cycle 25B.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.817
CDC25B	atrip	ENSPREP00000010131	ENSPREP00000021542	Cell division cycle 25B.	Uncharacterized protein.	0.600
CDC25B	cdc45	ENSPREP00000010131	ENSPREP00000017327	Cell division cycle 25B.	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.487
CDC25B	cdc6	ENSPREP00000010131	ENSPREP00000032222	Cell division cycle 25B.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.559
CDC25B	cdk2	ENSPREP00000010131	ENSPREP00000021129	Cell division cycle 25B.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.861
CDC25B	chek1	ENSPREP00000010131	ENSPREP00000025637	Cell division cycle 25B.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.998
CDC25B	mcm2	ENSPREP00000010131	ENSPREP00000033565	Cell division cycle 25B.	DNA helicase; Belongs to the MCM family.	0.433
CDC25B	mcm4	ENSPREP00000010131	ENSPREP00000012626	Cell division cycle 25B.	DNA helicase; Belongs to the MCM family.	0.458
CDC25B	mcm7	ENSPREP00000010131	ENSPREP00000020810	Cell division cycle 25B.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.421
CDC25B	orc1	ENSPREP00000010131	ENSPREP00000001890	Cell division cycle 25B.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.475
CDC25B	orc2	ENSPREP00000010131	ENSPREP00000031604	Cell division cycle 25B.	Origin recognition complex, subunit 2.	0.938
CDC25B	orc3	ENSPREP00000010131	ENSPREP00000030895	Cell division cycle 25B.	Origin recognition complex, subunit 3.	0.937
CDC25B	orc5	ENSPREP00000010131	ENSPREP00000032641	Cell division cycle 25B.	Origin recognition complex, subunit 5.	0.939
CLSPN	LOC103474198	ENSPREP00000015195	ENSPREP00000015219	Claspin.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.948
CLSPN	LOC103476593	ENSPREP00000015195	ENSPREP00000005951	Claspin.	Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family.	0.803
CLSPN	MCM7	ENSPREP00000015195	ENSPREP00000020776	Claspin.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.823
CLSPN	Mcm5	ENSPREP00000015195	ENSPREP00000022230	Claspin.	Uncharacterized protein.	0.923
CLSPN	RPA1	ENSPREP00000015195	ENSPREP00000014993	Claspin.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.948