(23 nodes) FGFR1 ligand binding and activation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103468250	Anosmin 1b. (720 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	ENSPREP00000004603	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	LOC103473660	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (503 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ANOS1	Anosmin 1. (675 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	LOC103469672	Fibroblast growth factor receptor. (831 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	ENSPREP00000018426	Uncharacterized protein. (108 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	ENSPREP00000022877	Uncharacterized protein. (62 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103470957	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (266 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (173 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANOS1	ENSPREP00000004603	ENSPREP00000001840	ENSPREP00000004603	Anosmin 1.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.454
ANOS1	ENSPREP00000006768	ENSPREP00000001840	ENSPREP00000006768	Anosmin 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.474
ANOS1	ENSPREP00000010497	ENSPREP00000001840	ENSPREP00000010497	Anosmin 1.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.474
ANOS1	ENSPREP00000018426	ENSPREP00000001840	ENSPREP00000018426	Anosmin 1.	Uncharacterized protein.	0.454
ANOS1	ENSPREP00000022877	ENSPREP00000001840	ENSPREP00000022877	Anosmin 1.	Uncharacterized protein.	0.454
ANOS1	Fgf20	ENSPREP00000001840	ENSPREP00000000359	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.474
ANOS1	LOC103462291	ENSPREP00000001840	ENSPREP00000002555	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.454
ANOS1	LOC103469672	ENSPREP00000001840	ENSPREP00000001007	Anosmin 1.	Fibroblast growth factor receptor.	0.746
ANOS1	LOC103470957	ENSPREP00000001840	ENSPREP00000032721	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.474
ANOS1	LOC103473660	ENSPREP00000001840	ENSPREP00000014108	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439
ANOS1	LOC103476521	ENSPREP00000001840	ENSPREP00000029747	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.760
ANOS1	fgf1	ENSPREP00000001840	ENSPREP00000007991	Anosmin 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.474
ANOS1	fgf10	ENSPREP00000001840	ENSPREP00000014875	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439
ANOS1	fgf17	ENSPREP00000001840	ENSPREP00000019823	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.516
ANOS1	fgf2	ENSPREP00000001840	ENSPREP00000009634	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.487
ANOS1	fgf22	ENSPREP00000001840	ENSPREP00000011331	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439
ANOS1	fgf23	ENSPREP00000001840	ENSPREP00000033759	Anosmin 1.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.636
ANOS1	fgf5	ENSPREP00000001840	ENSPREP00000004455	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
ENSPREP00000004603	ANOS1	ENSPREP00000004603	ENSPREP00000001840	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Anosmin 1.	0.454
ENSPREP00000004603	ENSPREP00000010497	ENSPREP00000004603	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.447