(72 nodes) NRAGE signals death through JNK network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103467571	FYVE, RhoGEF and PH domain containing 3. (621 aa)
	arhgef3	Rho guanine nucleotide exchange factor (GEF) 3. (642 aa)
	ENSPREP00000033113	Uncharacterized protein. (315 aa)
	LOC103464295	TGc domain-containing protein. (614 aa)
	ENSPREP00000032838	PDZ domain-containing protein. (113 aa)
	Arhgef12	DH domain-containing protein. (250 aa)
	vav2	Vav 2 guanine nucleotide exchange factor. (793 aa)
	arhgef10	Rho guanine nucleotide exchange factor (GEF) 10. (1441 aa)
	ENSPREP00000032370	TGc domain-containing protein. (561 aa)
	LOC103467350	Uncharacterized protein. (690 aa)
	LOC103472754	Rho guanine nucleotide exchange factor (GEF) 40. (1738 aa)
	ENSPREP00000031039	Rho guanine nucleotide exchange factor (GEF) 17. (435 aa)
	fgd4	FYVE, RhoGEF and PH domain containing 4. (690 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	ect2l	Coiled-coil domain containing 28A. (996 aa)
	LOC103467280	TGc domain-containing protein. (676 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (645 aa)
	ENSPREP00000026294	Trio Rho guanine nucleotide exchange factor a. (1127 aa)
	Trio	Trio Rho guanine nucleotide exchange factor a. (1516 aa)
	arhgef39	Rho guanine nucleotide exchange factor (GEF) 39. (427 aa)
	LOC103466715	Transglutaminase 2, like. (696 aa)
	arhgef16	Rho guanine nucleotide exchange factor (GEF) 16. (713 aa)
	LOC103459721	Neuroepithelial cell transforming 1. (633 aa)
	arhgef18	Rho/rac guanine nucleotide exchange factor (GEF) 18b. (1222 aa)
	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (894 aa)
	LOC103461187	Rho guanine nucleotide exchange factor (GEF) 3, like. (443 aa)
	Kalrn	Kalirin RhoGEF kinase a. (1623 aa)
	LOC103473221	Ras protein-specific guanine nucleotide-releasing factor 2a. (1319 aa)
	ENSPREP00000021400	T cell lymphoma invasion and metastasis 2b. (522 aa)
	arhgef1	Rho guanine nucleotide exchange factor (GEF) 1b. (1039 aa)
	ENSPREP00000021285	DH domain-containing protein. (251 aa)
	arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like a. (997 aa)
	LOC103474994	T cell lymphoma invasion and metastasis 1b. (1596 aa)
	aatf	Apoptosis antagonizing transcription factor. (548 aa)
	LOC103459587	Uncharacterized protein. (934 aa)
	ect2	Epithelial cell transforming 2. (1097 aa)
	LOC103465265	Uncharacterized protein. (661 aa)
	LOC103464037	MCF.2 cell line derived transforming sequence-like 2. (1009 aa)
	LOC103480472	Si:dkey-38p12.3. (1051 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1a. (1672 aa)
	rasgrf2	Ras protein-specific guanine nucleotide-releasing factor 2b. (1297 aa)
	fgd1	FYVE, RhoGEF and PH domain containing 1. (432 aa)
	prex1	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1503 aa)
	LOC103478369	Uncharacterized protein. (3064 aa)
	LOC108165628	Rho guanine nucleotide exchange factor (GEF) 7b. (621 aa)
	LOC103479751	Vav 3 guanine nucleotide exchange factor b. (801 aa)
	mcf2l	Mcf.2 cell line derived transforming sequence-like a. (1028 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (864 aa)
	arhgef6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (772 aa)
	ENSPREP00000015179	TGc domain-containing protein. (579 aa)
	arhgef19	Rho guanine nucleotide exchange factor (GEF) 19. (972 aa)
	ENSPREP00000014850	DH domain-containing protein. (196 aa)
	ENSPREP00000014835	SH3 domain-containing protein. (133 aa)
	mcf2	MCF.2 cell line derived transforming sequence a. (1145 aa)
	ENSPREP00000014656	Uncharacterized protein. (277 aa)
	LOC103479804	Rho guanine nucleotide exchange factor (GEF) 7a. (757 aa)
	arhgef11	Rho guanine nucleotide exchange factor (GEF) 11. (1475 aa)
	LOC103479717	Mcf.2 cell line derived transforming sequence-like b. (1176 aa)
	LOC103465802	Uncharacterized protein. (567 aa)
	arhgef37	Rho guanine nucleotide exchange factor (GEF) 37. (776 aa)
	LOC103460048	Uncharacterized protein. (1497 aa)
	sos1	Son of sevenless homolog 1 (Drosophila). (1138 aa)
	arhgef38	Rho guanine nucleotide exchange factor (GEF) 38. (804 aa)
	ENSPREP00000008107	Intersectin 1 (SH3 domain protein). (1107 aa)
	ENSPREP00000007450	Uncharacterized protein. (511 aa)
	ENSPREP00000006091	DH domain-containing protein. (227 aa)
	Sestd1	Uncharacterized protein. (96 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (1017 aa)
	Bcl2l11	Uncharacterized protein. (202 aa)
	LOC103480907	TGc domain-containing protein. (508 aa)
	tiam2	T cell lymphoma invasion and metastasis 2a. (1737 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (811 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF2	ENSPREP00000007450	ENSPREP00000023681	ENSPREP00000007450	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Uncharacterized protein.	0.427
ARHGEF2	ENSPREP00000008107	ENSPREP00000023681	ENSPREP00000008107	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Intersectin 1 (SH3 domain protein).	0.427
ARHGEF2	arhgef10	ENSPREP00000023681	ENSPREP00000032729	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Rho guanine nucleotide exchange factor (GEF) 10.	0.413
ARHGEF2	arhgef10l	ENSPREP00000023681	ENSPREP00000021019	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Rho guanine nucleotide exchange factor (GEF) 10-like a.	0.413
Arhgef12	ENSPREP00000007450	ENSPREP00000032828	ENSPREP00000007450	DH domain-containing protein.	Uncharacterized protein.	0.433
Arhgef12	ENSPREP00000008107	ENSPREP00000032828	ENSPREP00000008107	DH domain-containing protein.	Intersectin 1 (SH3 domain protein).	0.433
Arhgef12	ENSPREP00000031039	ENSPREP00000032828	ENSPREP00000031039	DH domain-containing protein.	Rho guanine nucleotide exchange factor (GEF) 17.	0.449
Arhgef12	arhgef10	ENSPREP00000032828	ENSPREP00000032729	DH domain-containing protein.	Rho guanine nucleotide exchange factor (GEF) 10.	0.402
Arhgef12	arhgef10l	ENSPREP00000032828	ENSPREP00000021019	DH domain-containing protein.	Rho guanine nucleotide exchange factor (GEF) 10-like a.	0.402
Arhgef12	ect2	ENSPREP00000032828	ENSPREP00000019129	DH domain-containing protein.	Epithelial cell transforming 2.	0.529
Bcl2l11	bad	ENSPREP00000002893	ENSPREP00000030076	Uncharacterized protein.	BCL2 associated agonist of cell death b.	0.751
ENSPREP00000006091	ect2l	ENSPREP00000006091	ENSPREP00000028120	DH domain-containing protein.	Coiled-coil domain containing 28A.	0.401
ENSPREP00000007450	ARHGEF2	ENSPREP00000007450	ENSPREP00000023681	Uncharacterized protein.	Rho/rac guanine nucleotide exchange factor (GEF) 2.	0.427
ENSPREP00000007450	Arhgef12	ENSPREP00000007450	ENSPREP00000032828	Uncharacterized protein.	DH domain-containing protein.	0.433
ENSPREP00000007450	ENSPREP00000008107	ENSPREP00000007450	ENSPREP00000008107	Uncharacterized protein.	Intersectin 1 (SH3 domain protein).	0.956
ENSPREP00000007450	ENSPREP00000021285	ENSPREP00000007450	ENSPREP00000021285	Uncharacterized protein.	DH domain-containing protein.	0.433
ENSPREP00000007450	ENSPREP00000021400	ENSPREP00000007450	ENSPREP00000021400	Uncharacterized protein.	T cell lymphoma invasion and metastasis 2b.	0.487
ENSPREP00000007450	ENSPREP00000032838	ENSPREP00000007450	ENSPREP00000032838	Uncharacterized protein.	PDZ domain-containing protein.	0.433
ENSPREP00000007450	LOC103474994	ENSPREP00000007450	ENSPREP00000020076	Uncharacterized protein.	T cell lymphoma invasion and metastasis 1b.	0.487
ENSPREP00000007450	LOC103479804	ENSPREP00000007450	ENSPREP00000012426	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 7a.	0.539