(17 nodes) GRB2 events in ERBB2 signaling network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	LOC103473479	EGF-like domain-containing protein. (217 aa)
	nrg2	Neuregulin 2b. (712 aa)
	Nrg3	EGF-like domain-containing protein. (95 aa)
	LOC103471128	Heparin-binding EGF-like growth factor a. (236 aa)
	nrg4	EGF-like domain-containing protein. (120 aa)
	LOC103469983	EGF-like domain-containing protein. (154 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (912 aa)
	LOC103473128	EGF-like domain-containing protein. (621 aa)
	LOC103469088	Zgc:55558. (191 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC103475452	Neuregulin 2a. (731 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	ENSPREP00000033510	Uncharacterized protein. (266 aa)
	LOC103481296	Uncharacterized protein. (562 aa)
	ENSPREP00000034025	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (548 aa)
	ENSPREP00000034033	Uncharacterized protein. (415 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSPREP00000034025	ENSPREP00000017340	ENSPREP00000034025	Cold shock domain containing E1, RNA-binding.	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.511
CSDE1	ENSPREP00000034033	ENSPREP00000017340	ENSPREP00000034033	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.511
CSDE1	LOC103469983	ENSPREP00000017340	ENSPREP00000013728	Cold shock domain containing E1, RNA-binding.	EGF-like domain-containing protein.	0.425
CSDE1	LOC103471128	ENSPREP00000017340	ENSPREP00000008653	Cold shock domain containing E1, RNA-binding.	Heparin-binding EGF-like growth factor a.	0.434
CSDE1	LOC103473128	ENSPREP00000017340	ENSPREP00000018279	Cold shock domain containing E1, RNA-binding.	EGF-like domain-containing protein.	0.401
CSDE1	LOC103473479	ENSPREP00000017340	ENSPREP00000004655	Cold shock domain containing E1, RNA-binding.	EGF-like domain-containing protein.	0.433
CSDE1	LOC103475452	ENSPREP00000017340	ENSPREP00000028296	Cold shock domain containing E1, RNA-binding.	Neuregulin 2a.	0.401
CSDE1	grb2	ENSPREP00000017340	ENSPREP00000022510	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.667
CSDE1	nrg2	ENSPREP00000017340	ENSPREP00000006018	Cold shock domain containing E1, RNA-binding.	Neuregulin 2b.	0.401
ENSPREP00000033510	LOC103481296	ENSPREP00000033510	ENSPREP00000033518	Uncharacterized protein.	Uncharacterized protein.	0.902
ENSPREP00000034025	CSDE1	ENSPREP00000034025	ENSPREP00000017340	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cold shock domain containing E1, RNA-binding.	0.511
ENSPREP00000034025	ENSPREP00000034033	ENSPREP00000034025	ENSPREP00000034033	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein.	0.881
ENSPREP00000034025	LOC103469088	ENSPREP00000034025	ENSPREP00000020359	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Zgc:55558.	0.511
ENSPREP00000034025	LOC103469983	ENSPREP00000034025	ENSPREP00000013728	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	EGF-like domain-containing protein.	0.592
ENSPREP00000034025	LOC103471128	ENSPREP00000034025	ENSPREP00000008653	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Heparin-binding EGF-like growth factor a.	0.667
ENSPREP00000034025	LOC103473128	ENSPREP00000034025	ENSPREP00000018279	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	EGF-like domain-containing protein.	0.819
ENSPREP00000034025	LOC103473479	ENSPREP00000034025	ENSPREP00000004655	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	EGF-like domain-containing protein.	0.502
ENSPREP00000034025	LOC103475452	ENSPREP00000034025	ENSPREP00000028296	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Neuregulin 2a.	0.730
ENSPREP00000034025	grb2	ENSPREP00000034025	ENSPREP00000022510	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Growth factor receptor-bound protein 2b.	0.823
ENSPREP00000034025	hras	ENSPREP00000034025	ENSPREP00000028573	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	HRas proto-oncogene, GTPase a.	0.511