(14 nodes) Biotin transport and metabolism network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103472253	Biotinidase. (368 aa)
	ENSPREP00000004578	CN hydrolase domain-containing protein. (404 aa)
	acaca	Acetyl-CoA carboxylase alpha. (2251 aa)
	HLCS	Holocarboxylase synthetase. (912 aa)
	LOC103458024	Solute carrier family 5 member 6a; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (634 aa)
	pc	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1180 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (657 aa)
	mccc2	Methylcrotonoyl-CoA carboxylase 2 (beta). (564 aa)
	pdzd11	PDZ domain containing 11. (161 aa)
	pccb	Propionyl-CoA carboxylase subunit beta. (561 aa)
	LOC103458340	Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (614 aa)
	acacb	Acetyl-CoA carboxylase beta. (2054 aa)
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (714 aa)
	LOC103463128	Si:ch211-198n5.11. (534 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004578	HLCS	ENSPREP00000004578	ENSPREP00000024353	CN hydrolase domain-containing protein.	Holocarboxylase synthetase.	0.935
ENSPREP00000004578	LOC103472253	ENSPREP00000004578	ENSPREP00000004662	CN hydrolase domain-containing protein.	Biotinidase.	0.901
HLCS	ENSPREP00000004578	ENSPREP00000024353	ENSPREP00000004578	Holocarboxylase synthetase.	CN hydrolase domain-containing protein.	0.935
HLCS	LOC103463128	ENSPREP00000024353	ENSPREP00000033644	Holocarboxylase synthetase.	Si:ch211-198n5.11.	0.818
HLCS	LOC103472253	ENSPREP00000024353	ENSPREP00000004662	Holocarboxylase synthetase.	Biotinidase.	0.935
HLCS	acaca	ENSPREP00000024353	ENSPREP00000001848	Holocarboxylase synthetase.	Acetyl-CoA carboxylase alpha.	0.864
HLCS	acacb	ENSPREP00000024353	ENSPREP00000033271	Holocarboxylase synthetase.	Acetyl-CoA carboxylase beta.	0.864
HLCS	mccc1	ENSPREP00000024353	ENSPREP00000033480	Holocarboxylase synthetase.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.823
HLCS	mccc2	ENSPREP00000024353	ENSPREP00000013194	Holocarboxylase synthetase.	Methylcrotonoyl-CoA carboxylase 2 (beta).	0.818
HLCS	pc	ENSPREP00000024353	ENSPREP00000029584	Holocarboxylase synthetase.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.975
HLCS	pcca	ENSPREP00000024353	ENSPREP00000011142	Holocarboxylase synthetase.	Propionyl-CoA carboxylase subunit alpha.	0.823
HLCS	pccb	ENSPREP00000024353	ENSPREP00000017427	Holocarboxylase synthetase.	Propionyl-CoA carboxylase subunit beta.	0.833
LOC103458024	pdzd11	ENSPREP00000029801	ENSPREP00000013931	Solute carrier family 5 member 6a; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	PDZ domain containing 11.	0.723
LOC103458340	pdzd11	ENSPREP00000025142	ENSPREP00000013931	Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	PDZ domain containing 11.	0.723
LOC103463128	HLCS	ENSPREP00000033644	ENSPREP00000024353	Si:ch211-198n5.11.	Holocarboxylase synthetase.	0.818
LOC103463128	acaca	ENSPREP00000033644	ENSPREP00000001848	Si:ch211-198n5.11.	Acetyl-CoA carboxylase alpha.	0.740
LOC103463128	acacb	ENSPREP00000033644	ENSPREP00000033271	Si:ch211-198n5.11.	Acetyl-CoA carboxylase beta.	0.740
LOC103463128	mccc1	ENSPREP00000033644	ENSPREP00000033480	Si:ch211-198n5.11.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.994
LOC103463128	mccc2	ENSPREP00000033644	ENSPREP00000013194	Si:ch211-198n5.11.	Methylcrotonoyl-CoA carboxylase 2 (beta).	0.904
LOC103463128	pc	ENSPREP00000033644	ENSPREP00000029584	Si:ch211-198n5.11.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.886