(60 nodes) Nicotinate metabolism network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000011149	Cytochrome P450, family 8, subfamily B, polypeptide 2; Belongs to the cytochrome P450 family. (512 aa)
	nadk2	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (433 aa)
	ENSPREP00000010060	Uncharacterized protein. (139 aa)
	Macrod2	Uncharacterized protein. (241 aa)
	LOC103460017	H2A histone family, member Y; Belongs to the histone H2A family. (336 aa)
	LOC103476165	Uncharacterized protein. (1113 aa)
	ENSPREP00000005088	Poly [ADP-ribose] polymerase. (323 aa)
	LOC103475948	Poly [ADP-ribose] polymerase. (791 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (296 aa)
	LOC103464557	Prostaglandin I2 (prostacyclin) synthase; Belongs to the cytochrome P450 family. (486 aa)
	LOC103456801	Uncharacterized protein. (329 aa)
	rnls	Renalase, FAD-dependent amine oxidase. (349 aa)
	LOC103466217	Poly (ADP-ribose) polymerase family, member 12a. (697 aa)
	LOC103466215	Poly (ADP-ribose) polymerase family, member 12a. (703 aa)
	naxd	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (647 aa)
	nadsyn1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (663 aa)
	LOC103459299	Uncharacterized protein. (614 aa)
	LOC103456559	Solute carrier family 22 member 13b. (540 aa)
	LOC103456560	Solute carrier family 22 member 13b. (510 aa)
	LOC103456561	Solute carrier family 22 member 13b. (539 aa)
	fam162a	Family with sequence similarity 162 member A. (142 aa)
	LOC103465472	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (494 aa)
	gdap2	Ganglioside induced differentiation associated protein 2. (496 aa)
	nmnat2	Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
	ENSPREP00000028585	Macro domain-containing protein. (508 aa)
	ENSPREP00000028525	Uncharacterized protein. (254 aa)
	ENSPREP00000028501	Poly [ADP-ribose] polymerase. (672 aa)
	ENSPREP00000028395	Uncharacterized protein. (136 aa)
	ENSPREP00000028349	Poly [ADP-ribose] polymerase. (720 aa)
	ENSPREP00000028311	Uncharacterized protein. (97 aa)
	LOC103461817	Uncharacterized protein. (797 aa)
	LOC108165898	Poly (ADP-ribose) polymerase family, member 12b. (427 aa)
	ENSPREP00000028104	Uncharacterized protein. (85 aa)
	nudt12	Nudix (nucleoside diphosphate linked moiety X)-type motif 12. (462 aa)
	LOC108167021	Uncharacterized protein. (223 aa)
	ENSPREP00000027738	Poly [ADP-ribose] polymerase. (685 aa)
	ENSPREP00000027704	Uncharacterized protein. (220 aa)
	LOC103464095	Uncharacterized protein. (197 aa)
	ENSPREP00000025444	Poly [ADP-ribose] polymerase. (1527 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (701 aa)
	ENSPREP00000024086	Poly [ADP-ribose] polymerase. (305 aa)
	parp16	Poly [ADP-ribose] polymerase. (316 aa)
	nmnat1	Nicotinamide-nucleotide adenylyltransferase. (285 aa)
	macrod1	Mono-ADP ribosylhydrolase 1. (366 aa)
	LOC103470104	Nicotinamide riboside kinase 1. (224 aa)
	LOC103479319	Nicotinamide-nucleotide adenylyltransferase. (265 aa)
	LOC103479795	NAD kinase b. (491 aa)
	LOC103479788	Nicotinamide riboside kinase 2. (202 aa)
	slc5a8	Solute carrier family 5 member 8; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (611 aa)
	nt5e	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (647 aa)
	nampt	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (505 aa)
	nadk	NAD kinase a. (361 aa)
	naprt	Nicotinate phosphoribosyltransferase. (608 aa)
	naxe	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (306 aa)
	PTGIS	Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (483 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (615 aa)
	LOC103462093	Muscle-specific beta 1 integrin binding protein 2. (206 aa)
	LOC103480296	Poly [ADP-ribose] polymerase. (1590 aa)
	ENSPREP00000010946	Poly [ADP-ribose] polymerase. (303 aa)
	yjefn3	YjeF N-terminal domain containing 3. (253 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005088	ENSPREP00000028525	ENSPREP00000005088	ENSPREP00000028525	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.530
ENSPREP00000005088	ENSPREP00000028585	ENSPREP00000005088	ENSPREP00000028585	Poly [ADP-ribose] polymerase.	Macro domain-containing protein.	0.644
ENSPREP00000010946	ENSPREP00000028585	ENSPREP00000010946	ENSPREP00000028585	Poly [ADP-ribose] polymerase.	Macro domain-containing protein.	0.889
ENSPREP00000010946	LOC103476165	ENSPREP00000010946	ENSPREP00000005114	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.523
ENSPREP00000024086	parp16	ENSPREP00000024086	ENSPREP00000023355	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.471
ENSPREP00000025444	LOC103461817	ENSPREP00000025444	ENSPREP00000028279	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.448
ENSPREP00000027704	LOC103460017	ENSPREP00000027704	ENSPREP00000008313	Uncharacterized protein.	H2A histone family, member Y; Belongs to the histone H2A family.	0.459
ENSPREP00000027738	LOC103460017	ENSPREP00000027738	ENSPREP00000008313	Poly [ADP-ribose] polymerase.	H2A histone family, member Y; Belongs to the histone H2A family.	0.459
ENSPREP00000027738	LOC108167021	ENSPREP00000027738	ENSPREP00000027759	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.924
ENSPREP00000028104	naprt	ENSPREP00000028104	ENSPREP00000013654	Uncharacterized protein.	Nicotinate phosphoribosyltransferase.	0.414
ENSPREP00000028311	LOC103466215	ENSPREP00000028311	ENSPREP00000000850	Uncharacterized protein.	Poly (ADP-ribose) polymerase family, member 12a.	0.411
ENSPREP00000028311	LOC103466217	ENSPREP00000028311	ENSPREP00000000854	Uncharacterized protein.	Poly (ADP-ribose) polymerase family, member 12a.	0.411
ENSPREP00000028311	LOC108165898	ENSPREP00000028311	ENSPREP00000028256	Uncharacterized protein.	Poly (ADP-ribose) polymerase family, member 12b.	0.411
ENSPREP00000028311	parp16	ENSPREP00000028311	ENSPREP00000023355	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.445
ENSPREP00000028349	ENSPREP00000028525	ENSPREP00000028349	ENSPREP00000028525	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.855
ENSPREP00000028349	LOC103461817	ENSPREP00000028349	ENSPREP00000028279	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.494
ENSPREP00000028349	gdap2	ENSPREP00000028349	ENSPREP00000028766	Poly [ADP-ribose] polymerase.	Ganglioside induced differentiation associated protein 2.	0.501
ENSPREP00000028501	ENSPREP00000028525	ENSPREP00000028501	ENSPREP00000028525	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.888
ENSPREP00000028501	LOC103461817	ENSPREP00000028501	ENSPREP00000028279	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.491
ENSPREP00000028525	ENSPREP00000005088	ENSPREP00000028525	ENSPREP00000005088	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.530