(21 nodes) Signaling by ALK network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	Pik3ca	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (306 aa)
	LOC103475907	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ENSPREP00000004470	Uncharacterized protein. (64 aa)
	ENSPREP00000007305	Tyrosine-protein kinase receptor. (512 aa)
	LOC103457471	MYCN proto-oncogene, bHLH transcription factor. (459 aa)
	ENSPREP00000008873	PR/SET domain 1. (783 aa)
	LOC103479066	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ptprz1	Protein tyrosine phosphatase receptor type Z1a. (1888 aa)
	jak3	Tyrosine-protein kinase. (975 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (573 aa)
	LOC103473100	PR domain containing 1b, with ZNF domain. (758 aa)
	LOC103459662	Protein tyrosine phosphatase receptor type Z1b. (1436 aa)
	LOC103458875	Tyrosine-protein kinase receptor. (1453 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1271 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (876 aa)
	Mdk	Midkine b. (148 aa)
	ptn	Pleiotrophin. (161 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004470	LOC103468460	ENSPREP00000004470	ENSPREP00000026558	Uncharacterized protein.	E1A binding protein p300 b.	0.683
ENSPREP00000004470	LOC103482005	ENSPREP00000004470	ENSPREP00000030842	Uncharacterized protein.	E1A binding protein p300 a.	0.683
ENSPREP00000007305	LOC103457471	ENSPREP00000007305	ENSPREP00000008659	Tyrosine-protein kinase receptor.	MYCN proto-oncogene, bHLH transcription factor.	0.558
ENSPREP00000007305	LOC103459662	ENSPREP00000007305	ENSPREP00000022489	Tyrosine-protein kinase receptor.	Protein tyrosine phosphatase receptor type Z1b.	0.488
ENSPREP00000007305	LOC103475907	ENSPREP00000007305	ENSPREP00000003309	Tyrosine-protein kinase receptor.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.470
ENSPREP00000007305	LOC103479066	ENSPREP00000007305	ENSPREP00000009342	Tyrosine-protein kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.520
ENSPREP00000007305	Mdk	ENSPREP00000007305	ENSPREP00000030713	Tyrosine-protein kinase receptor.	Midkine b.	0.769
ENSPREP00000007305	Pik3ca	ENSPREP00000007305	ENSPREP00000033418	Tyrosine-protein kinase receptor.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.520
ENSPREP00000007305	jak3	ENSPREP00000007305	ENSPREP00000012383	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.427
ENSPREP00000007305	pik3cb	ENSPREP00000007305	ENSPREP00000016620	Tyrosine-protein kinase receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.531
ENSPREP00000007305	plcg1	ENSPREP00000007305	ENSPREP00000027159	Tyrosine-protein kinase receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.583
ENSPREP00000007305	ptn	ENSPREP00000007305	ENSPREP00000032939	Tyrosine-protein kinase receptor.	Pleiotrophin.	0.802
ENSPREP00000007305	ptpn6	ENSPREP00000007305	ENSPREP00000016776	Tyrosine-protein kinase receptor.	Protein tyrosine phosphatase non-receptor type 6.	0.491
ENSPREP00000007305	ptprz1	ENSPREP00000007305	ENSPREP00000010703	Tyrosine-protein kinase receptor.	Protein tyrosine phosphatase receptor type Z1a.	0.488
ENSPREP00000007305	shc1	ENSPREP00000007305	ENSPREP00000025346	Tyrosine-protein kinase receptor.	SHC (Src homology 2 domain containing) transforming protein 1.	0.654
LOC103457471	ENSPREP00000007305	ENSPREP00000008659	ENSPREP00000007305	MYCN proto-oncogene, bHLH transcription factor.	Tyrosine-protein kinase receptor.	0.558
LOC103457471	LOC103458875	ENSPREP00000008659	ENSPREP00000024668	MYCN proto-oncogene, bHLH transcription factor.	Tyrosine-protein kinase receptor.	0.558
LOC103458875	LOC103457471	ENSPREP00000024668	ENSPREP00000008659	Tyrosine-protein kinase receptor.	MYCN proto-oncogene, bHLH transcription factor.	0.558
LOC103458875	LOC103459662	ENSPREP00000024668	ENSPREP00000022489	Tyrosine-protein kinase receptor.	Protein tyrosine phosphatase receptor type Z1b.	0.488
LOC103458875	LOC103475907	ENSPREP00000024668	ENSPREP00000003309	Tyrosine-protein kinase receptor.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.470