(58 nodes) Downstream TCR signaling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000013245	Ig-like domain-containing protein. (124 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (600 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (412 aa)
	fbxw11	F-box and WD repeat domain containing 11a. (562 aa)
	LOC103462243	DDE_Tnp_1_7 domain-containing protein. (632 aa)
	ENSPREP00000004637	Uncharacterized protein. (473 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	ENSPREP00000005976	Si:ch211-130m23.5. (677 aa)
	map3k20	Uncharacterized protein. (796 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (583 aa)
	ENSPREP00000008732	DDE_Tnp_1_7 domain-containing protein. (619 aa)
	ENSPREP00000009191	Ig-like domain-containing protein. (143 aa)
	LOC108165885	DDE_Tnp_1_7 domain-containing protein. (565 aa)
	ubb	Uncharacterized protein. (179 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	ENSPREP00000009964	Ubiquitin-like domain-containing protein. (95 aa)
	LOC103475178	Ig_4 domain-containing protein. (169 aa)
	cd3e	Ig_4 domain-containing protein. (185 aa)
	LOC103474821	Uncharacterized protein. (175 aa)
	LOC103466618	MALT paracaspase 3. (573 aa)
	LOC103469935	MALT paracaspase 1. (828 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (315 aa)
	ENSPREP00000013077	Ig-like domain-containing protein. (272 aa)
	ENSPREP00000013135	Ig-like domain-containing protein. (139 aa)
	LOC103469342	DDE_Tnp_1_7 domain-containing protein. (632 aa)
	ENSPREP00000013216	Uncharacterized protein. (207 aa)
	ENSPREP00000013267	Uncharacterized protein. (246 aa)
	ENSPREP00000013297	IGv domain-containing protein. (125 aa)
	ENSPREP00000015976	DDE_Tnp_1_7 domain-containing protein. (559 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	ube2n	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	ENSPREP00000018384	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (290 aa)
	ENSPREP00000018398	MALT paracaspase 2. (715 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC103477977	Uncharacterized protein. (439 aa)
	LOC103479332	Protein kinase domain-containing protein. (674 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (772 aa)
	LOC103476793	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
	LOC103473189	Uncharacterized protein. (154 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1102 aa)
	ENSPREP00000024682	KxDL motif containing 1. (197 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (538 aa)
	LOC103466094	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (209 aa)
	ENSPREP00000026589	Ig-like domain-containing protein. (142 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (719 aa)
	ENSPREP00000027430	CARD domain-containing protein. (524 aa)
	LOC103468544	Guanylate kinase-like domain-containing protein. (308 aa)
	LOC103457805	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	LOC103457186	DDE_Tnp_1_7 domain-containing protein. (611 aa)
	LOC108166190	DDE_Tnp_1_7 domain-containing protein. (626 aa)
	ENSPREP00000029705	DDE_Tnp_1_7 domain-containing protein. (540 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (742 aa)
	LOC103473354	Uncharacterized protein. (623 aa)
	LOC103476976	Component of inhibitor of nuclear factor kappa B kinase complex. (689 aa)
	ENSPREP00000033022	DDE_Tnp_1_7 domain-containing protein. (529 aa)
	LOC103457762	DDE_Tnp_1_7 domain-containing protein. (570 aa)
	LOC103457799	Uncharacterized protein. (149 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSPREP00000009964	ENSPREP00000020163	ENSPREP00000009964	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-like domain-containing protein.	0.477
CHUK	ENSPREP00000018384	ENSPREP00000020163	ENSPREP00000018384	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.963
CHUK	ENSPREP00000018398	ENSPREP00000020163	ENSPREP00000018398	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 2.	0.472
CHUK	ENSPREP00000027430	ENSPREP00000020163	ENSPREP00000027430	Component of inhibitor of nuclear factor kappa B kinase complex.	CARD domain-containing protein.	0.569
CHUK	LOC103457805	ENSPREP00000020163	ENSPREP00000027480	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.958
CHUK	LOC103466094	ENSPREP00000020163	ENSPREP00000026505	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.512
CHUK	LOC103466618	ENSPREP00000020163	ENSPREP00000011487	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 3.	0.944
CHUK	LOC103468544	ENSPREP00000020163	ENSPREP00000027446	Component of inhibitor of nuclear factor kappa B kinase complex.	Guanylate kinase-like domain-containing protein.	0.569
CHUK	LOC103469935	ENSPREP00000020163	ENSPREP00000011835	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 1.	0.944
CHUK	LOC103473189	ENSPREP00000020163	ENSPREP00000021152	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.477
CHUK	LOC103476976	ENSPREP00000020163	ENSPREP00000032137	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.943
CHUK	LOC103479332	ENSPREP00000020163	ENSPREP00000019978	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.626
CHUK	PTEN	ENSPREP00000020163	ENSPREP00000002303	Component of inhibitor of nuclear factor kappa B kinase complex.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.922
CHUK	fbxw11	ENSPREP00000020163	ENSPREP00000002506	Component of inhibitor of nuclear factor kappa B kinase complex.	F-box and WD repeat domain containing 11a.	0.609
CHUK	ikbkb	ENSPREP00000020163	ENSPREP00000016563	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.950
CHUK	ikbkg	ENSPREP00000020163	ENSPREP00000007994	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.850
CHUK	map3k20	ENSPREP00000020163	ENSPREP00000007414	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.626
CHUK	map3k7	ENSPREP00000020163	ENSPREP00000002180	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7.	0.961
CHUK	nfkbia	ENSPREP00000020163	ENSPREP00000012072	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.958
CHUK	pdpk1	ENSPREP00000020163	ENSPREP00000026362	Component of inhibitor of nuclear factor kappa B kinase complex.	3-phosphoinositide dependent protein kinase 1b.	0.949