(17 nodes) Alpha-linolenic acid (ALA) metabolism network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	LOC103466511	Fatty acid desaturase 2. (445 aa)
	elovl5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (294 aa)
	acot8	Acyl-CoA thioesterase 8. (321 aa)
	hsdl2	Hydroxysteroid dehydrogenase like 2. (490 aa)
	hsd17b4	Hydroxysteroid (17-beta) dehydrogenase 4. (737 aa)
	podn	Podocan. (587 aa)
	LOC103477396	Elongation of very long chain fatty acids protein. (283 aa)
	LOC103460228	ATP-binding cassette, sub-family D (ALD), member 1. (785 aa)
	LOC103466509	Fatty acid desaturase 2. (445 aa)
	LOC103466510	Fatty acid desaturase 2. (460 aa)
	LOC103463592	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (407 aa)
	LOC103481830	Elongation of very long chain fatty acids protein. (252 aa)
	acsl1	Acyl-CoA synthetase long chain family member 1a. (698 aa)
	scp2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (572 aa)
	acaa1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)
	LOC103479605	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (312 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (691 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL1	acaa1	ENSPREP00000003059	ENSPREP00000006361	Acyl-CoA synthetase long chain family member 1.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.551
ACSL1	acsl1	ENSPREP00000003059	ENSPREP00000007641	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 1a.	0.605
ACSL1	hsd17b4	ENSPREP00000003059	ENSPREP00000021168	Acyl-CoA synthetase long chain family member 1.	Hydroxysteroid (17-beta) dehydrogenase 4.	0.406
ACSL1	hsdl2	ENSPREP00000003059	ENSPREP00000025733	Acyl-CoA synthetase long chain family member 1.	Hydroxysteroid dehydrogenase like 2.	0.562
ACSL1	scp2	ENSPREP00000003059	ENSPREP00000006966	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.593
LOC103460228	acaa1	ENSPREP00000018941	ENSPREP00000006361	ATP-binding cassette, sub-family D (ALD), member 1.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.458
LOC103460228	hsd17b4	ENSPREP00000018941	ENSPREP00000021168	ATP-binding cassette, sub-family D (ALD), member 1.	Hydroxysteroid (17-beta) dehydrogenase 4.	0.463
LOC103460228	hsdl2	ENSPREP00000018941	ENSPREP00000025733	ATP-binding cassette, sub-family D (ALD), member 1.	Hydroxysteroid dehydrogenase like 2.	0.436
LOC103460228	scp2	ENSPREP00000018941	ENSPREP00000006966	ATP-binding cassette, sub-family D (ALD), member 1.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.690
LOC103463592	LOC103479605	ENSPREP00000015557	ENSPREP00000004053	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...]	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...]	0.901
LOC103466509	LOC103466510	ENSPREP00000017266	ENSPREP00000017245	Fatty acid desaturase 2.	Fatty acid desaturase 2.	0.900
LOC103466509	LOC103466511	ENSPREP00000017266	ENSPREP00000017173	Fatty acid desaturase 2.	Fatty acid desaturase 2.	0.900
LOC103466509	elovl5	ENSPREP00000017266	ENSPREP00000032681	Fatty acid desaturase 2.	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	0.712
LOC103466510	LOC103466509	ENSPREP00000017245	ENSPREP00000017266	Fatty acid desaturase 2.	Fatty acid desaturase 2.	0.900
LOC103466510	LOC103466511	ENSPREP00000017245	ENSPREP00000017173	Fatty acid desaturase 2.	Fatty acid desaturase 2.	0.901
LOC103466510	elovl5	ENSPREP00000017245	ENSPREP00000032681	Fatty acid desaturase 2.	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	0.712
LOC103466511	LOC103466509	ENSPREP00000017173	ENSPREP00000017266	Fatty acid desaturase 2.	Fatty acid desaturase 2.	0.900
LOC103466511	LOC103466510	ENSPREP00000017173	ENSPREP00000017245	Fatty acid desaturase 2.	Fatty acid desaturase 2.	0.901
LOC103466511	elovl5	ENSPREP00000017173	ENSPREP00000032681	Fatty acid desaturase 2.	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	0.712
LOC103477396	elovl5	ENSPREP00000019064	ENSPREP00000032681	Elongation of very long chain fatty acids protein.	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	0.942