(38 nodes) Notch-HLH transcription pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103464091	CREB binding protein a. (2371 aa)
	ncor2	Nuclear receptor corepressor 2. (2291 aa)
	LOC103459281	Transducin beta like 1 X-linked. (513 aa)
	LOC103467053	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (821 aa)
	LOC103458631	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	LOC103464932	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (923 aa)
	LOC103473440	Notch receptor 1a. (2478 aa)
	hdac9	Histone deacetylase 9b. (631 aa)
	maml3	Mastermind-like transcriptional coactivator 3. (1158 aa)
	ENSPREP00000004470	Uncharacterized protein. (64 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1136 aa)
	ENSPREP00000008634	Uncharacterized protein. (690 aa)
	LOC103479069	Transducin (beta)-like 1 X-linked receptor 1b. (514 aa)
	kat2b	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (798 aa)
	ncor1	Nuclear receptor corepressor 1. (2343 aa)
	notch1	Notch receptor 1b. (2491 aa)
	crebbp	CREB binding protein b. (2452 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (797 aa)
	LOC103469257	Recombination signal binding protein for immunoglobulin kappa J region a. (491 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (435 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region. (490 aa)
	LOC103463303	Crumbs cell polarity complex component 1. (1334 aa)
	hdac6	Histone deacetylase 6. (899 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1105 aa)
	LOC103474968	Histone deacetylase 12. (345 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	crb2	Crumbs cell polarity complex component 2b. (1343 aa)
	LOC103473166	Uncharacterized protein. (1465 aa)
	maml2	MamL-1 domain-containing protein. (908 aa)
	LOC103461731	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1063 aa)
	LOC103472045	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	snw1	SNW domain containing 1. (536 aa)
	hdac10	Histone deacetylase 10. (665 aa)
	hdac11	Histone deacetylase 11. (367 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
	ENSPREP00000033286	Uncharacterized protein. (373 aa)
	ENSPREP00000033301	Uncharacterized protein. (756 aa)
	Eys	Uncharacterized protein. (303 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004470	HDAC4	ENSPREP00000004470	ENSPREP00000018575	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103459281	ENSPREP00000004470	ENSPREP00000001930	Uncharacterized protein.	Transducin beta like 1 X-linked.	0.839
ENSPREP00000004470	LOC103461731	ENSPREP00000004470	ENSPREP00000024983	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103464091	ENSPREP00000004470	ENSPREP00000000408	Uncharacterized protein.	CREB binding protein a.	0.715
ENSPREP00000004470	LOC103464932	ENSPREP00000004470	ENSPREP00000002559	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103467053	ENSPREP00000004470	ENSPREP00000002291	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103469257	ENSPREP00000004470	ENSPREP00000015443	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.735
ENSPREP00000004470	LOC103479069	ENSPREP00000004470	ENSPREP00000009479	Uncharacterized protein.	Transducin (beta)-like 1 X-linked receptor 1b.	0.839
ENSPREP00000004470	TBL1XR1	ENSPREP00000004470	ENSPREP00000019466	Uncharacterized protein.	Transducin beta like 1 X-linked receptor 1.	0.839
ENSPREP00000004470	crebbp	ENSPREP00000004470	ENSPREP00000011232	Uncharacterized protein.	CREB binding protein b.	0.715
ENSPREP00000004470	hdac10	ENSPREP00000004470	ENSPREP00000028114	Uncharacterized protein.	Histone deacetylase 10.	0.441
ENSPREP00000004470	hdac5	ENSPREP00000004470	ENSPREP00000008588	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	hdac6	ENSPREP00000004470	ENSPREP00000018344	Uncharacterized protein.	Histone deacetylase 6.	0.441
ENSPREP00000004470	hdac9	ENSPREP00000004470	ENSPREP00000002660	Uncharacterized protein.	Histone deacetylase 9b.	0.441
ENSPREP00000004470	kat2a	ENSPREP00000004470	ENSPREP00000015085	Uncharacterized protein.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.555
ENSPREP00000004470	kat2b	ENSPREP00000004470	ENSPREP00000009570	Uncharacterized protein.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.555
ENSPREP00000004470	ncor1	ENSPREP00000004470	ENSPREP00000009626	Uncharacterized protein.	Nuclear receptor corepressor 1.	0.954
ENSPREP00000004470	ncor2	ENSPREP00000004470	ENSPREP00000001887	Uncharacterized protein.	Nuclear receptor corepressor 2.	0.954
ENSPREP00000004470	rbpj	ENSPREP00000004470	ENSPREP00000016630	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.735
ENSPREP00000004470	snw1	ENSPREP00000004470	ENSPREP00000027074	Uncharacterized protein.	SNW domain containing 1.	0.673