(38 nodes) Netrin-1 signaling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103473771	Unc-5 netrin receptor C. (922 aa)
	LOC103466877	Mitogen-activated protein kinase. (364 aa)
	LOC103464907	Mitogen-activated protein kinase. (363 aa)
	unc5b	Unc-5 netrin receptor B. (929 aa)
	LOC103466341	Uncharacterized protein. (667 aa)
	unc5a	Unc-5 netrin receptor A. (903 aa)
	LOC103462159	Immunoglobulin superfamily, DCC subclass, member 4. (1239 aa)
	neo1	Neogenin 1. (1402 aa)
	ENSPREP00000011095	HP domain-containing protein. (142 aa)
	ENSPREP00000011137	Uncharacterized protein. (380 aa)
	EZR	Ezrin b. (582 aa)
	agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (1321 aa)
	LOC103463666	RGM domain family, member D. (472 aa)
	LOC103467000	Mitogen-activated protein kinase. (366 aa)
	LOC103476139	Down syndrome cell adhesion molecule a. (2028 aa)
	LOC103456779	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1. (1082 aa)
	ENSPREP00000019743	Uncharacterized protein. (760 aa)
	ENSPREP00000019795	Ig-like domain-containing protein. (130 aa)
	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1223 aa)
	unc5d	Unc-5 netrin receptor Db. (917 aa)
	LOC103459704	Mitogen-activated protein kinase. (366 aa)
	LOC103474387	Down syndrome cell adhesion molecule b. (2070 aa)
	LOC103459765	Mitogen-activated protein kinase. (348 aa)
	ENSPREP00000024650	RGM_C domain-containing protein. (198 aa)
	pak1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	LOC103465074	Si:dkey-202e22.2. (601 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (719 aa)
	LOC103470231	Unc-5 netrin receptor C. (955 aa)
	ablim3	Actin binding LIM protein family, member 3. (695 aa)
	agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1126 aa)
	LOC103473501	Unc-5 netrin receptor Da. (874 aa)
	LOC103466203	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	DSCAML1	DS cell adhesion molecule like 1. (2023 aa)
	ablim2	Actin binding LIM protein family, member 2. (672 aa)
	ntn4	Netrin 4. (624 aa)
	LOC103467285	Mitogen-activated protein kinase. (347 aa)
	LOC103474608	Down syndrome cell adhesion molecule like 1. (2091 aa)
	PAK3	Non-specific serine/threonine protein kinase. (575 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP2	agap2	ENSPREP00000021827	ENSPREP00000029925	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	0.903
AGAP2	unc5b	ENSPREP00000021827	ENSPREP00000005104	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	Unc-5 netrin receptor B.	0.523
DSCAML1	ENSPREP00000019743	ENSPREP00000031898	ENSPREP00000019743	DS cell adhesion molecule like 1.	Uncharacterized protein.	0.499
DSCAML1	ENSPREP00000019795	ENSPREP00000031898	ENSPREP00000019795	DS cell adhesion molecule like 1.	Ig-like domain-containing protein.	0.499
DSCAML1	LOC103462159	ENSPREP00000031898	ENSPREP00000008506	DS cell adhesion molecule like 1.	Immunoglobulin superfamily, DCC subclass, member 4.	0.445
DSCAML1	LOC103476139	ENSPREP00000031898	ENSPREP00000015397	DS cell adhesion molecule like 1.	Down syndrome cell adhesion molecule a.	0.413
DSCAML1	PAK3	ENSPREP00000031898	ENSPREP00000034117	DS cell adhesion molecule like 1.	Non-specific serine/threonine protein kinase.	0.440
DSCAML1	neo1	ENSPREP00000031898	ENSPREP00000009288	DS cell adhesion molecule like 1.	Neogenin 1.	0.499
DSCAML1	pak1	ENSPREP00000031898	ENSPREP00000025701	DS cell adhesion molecule like 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.440
ENSPREP00000011095	ENSPREP00000011137	ENSPREP00000011095	ENSPREP00000011137	HP domain-containing protein.	Uncharacterized protein.	0.472
ENSPREP00000011095	ablim2	ENSPREP00000011095	ENSPREP00000032061	HP domain-containing protein.	Actin binding LIM protein family, member 2.	0.519
ENSPREP00000011137	ENSPREP00000011095	ENSPREP00000011137	ENSPREP00000011095	Uncharacterized protein.	HP domain-containing protein.	0.472
ENSPREP00000019743	DSCAML1	ENSPREP00000019743	ENSPREP00000031898	Uncharacterized protein.	DS cell adhesion molecule like 1.	0.499
ENSPREP00000019743	ENSPREP00000019795	ENSPREP00000019743	ENSPREP00000019795	Uncharacterized protein.	Ig-like domain-containing protein.	0.841
ENSPREP00000019743	ENSPREP00000024650	ENSPREP00000019743	ENSPREP00000024650	Uncharacterized protein.	RGM_C domain-containing protein.	0.604
ENSPREP00000019743	EZR	ENSPREP00000019743	ENSPREP00000011767	Uncharacterized protein.	Ezrin b.	0.420
ENSPREP00000019743	LOC103463666	ENSPREP00000019743	ENSPREP00000012090	Uncharacterized protein.	RGM domain family, member D.	0.604
ENSPREP00000019743	LOC103465074	ENSPREP00000019743	ENSPREP00000025938	Uncharacterized protein.	Si:dkey-202e22.2.	0.570
ENSPREP00000019743	LOC103466341	ENSPREP00000019743	ENSPREP00000006165	Uncharacterized protein.	Uncharacterized protein.	0.570
ENSPREP00000019743	LOC103470231	ENSPREP00000019743	ENSPREP00000029499	Uncharacterized protein.	Unc-5 netrin receptor C.	0.570